scholarly journals Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats

2015 ◽  
Vol 7 (1) ◽  
pp. 56 ◽  
Author(s):  
Zakieh Keshavarzi ◽  
Mohammad Khaksari ◽  
Nader Shahrokhi
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Ulcer Healing

scholarly journals Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

2008 ◽  
Vol 51 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Cristina Setim Freitas ◽  
Cristiane Hatsuko Baggio ◽  
Samanta Luiza Araújo ◽  
Maria Consuelo Andrade Marques
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Healing Process ◽  
Intraperitoneal Administration ◽  
Oral Route ◽  
Chronic Gastric Ulcer ◽  
Pfaffia Glomerata ◽  
Tissue Healing

The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.

scholarly journals Effect of aqueous extract of aloe vera leaves on gut-brain axis response following acetic acid -induced gastric ulcer in male rats

2014 ◽  
Vol 6 (2) ◽  
pp. 347-357
Author(s):  
M Sabaghian ◽  
Z Keshavarzi ◽  
B Bibak ◽  
M Vatanchian ◽  
T Mohammad Rezapour
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Aloe Vera ◽  
Male Rats

Aqueous Extract of Enantia chlorantha (Annonaceae) Prevents the Delay in Chronic Gastric Ulcer Healing Caused by Indomethacin in Rats

2015 ◽  
Vol 8 (1) ◽  
pp. 1-13
Author(s):  
Kuissu Mesmine ◽  
Enow-Orock George ◽  
Mezui Christophe ◽  
Nkwengoua Ernestine ◽  
Tan Paul ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Ulcer Healing ◽  
Chronic Gastric Ulcer ◽  
Gastric Ulcer Healing

scholarly journals Immunohistochemical Studies of Age-Related Changes in Cell Proliferation and Angiogenesis during the Healing of Acetic Acid-Induced Gastric Ulcers in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
A. Folorunsho Ajayi ◽  
S. Babafemi Olaleye
Keyword(s):  
Cell Proliferation ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Factor Viii ◽  
Ulcer Healing ◽  
Gastric Ulcers ◽  
Gastric Injury ◽  
Tissue Samples ◽  
Age Related ◽  
Male Wistar Rats

Cell proliferation and angiogenesis are of utmost importance for healing to take place. The KI67 and EGFR proteins are markers of cell proliferation, while CD31 and factor VIII are markers of angiogenesis. To elucidate the mechanism responsible for delayed healing of the gastric injury in old age, we analyzed the expression of these markers in rats of different months during the healing of an acetic acid-induced gastric ulcer. Male Wistar rats (aged 3, 6, 12, and 18 months) divided into four groups, according to their ages, formed the experimental animals. Stomach tissue samples were collected on days 3, 7, 14, and 21 after induction for assessment of ulcer healing. The area of gastric mucosa healed was inversely proportional to age. The expression of markers of proliferation (KI67 and EGFR) and angiogenesis (factor VIII and CD31) decreased significantly (p<0.05) in older rats when compared with younger ones (3 months > six months > 12 months > 18 months) on days 7, 14, and 21 after induction of gastric ulcer. This study revealed that the slower gastric ulcer healing rate in older rats might be due to reduced epithelial cell proliferation and angiogenic activities.

Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats

Inflammation ◽  
2008 ◽  
Vol 32 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Berna Karakoyun ◽  
Meral Yüksel ◽  
Feriha Ercan ◽  
Can Erzik ◽  
Berrak Ç. Yeğen
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Lipoic Acid ◽  
Ulcer Healing ◽  
Alpha Lipoic Acid ◽  
Gastric Ulcer Healing

S1634 Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats

2008 ◽  
Vol 134 (4) ◽  
pp. A-239
Author(s):  
Berna Karakoyun ◽  
Meral Yuksel ◽  
Feriha Ercan ◽  
Can Erzik ◽  
Berrak C. Yegen
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Lipoic Acid ◽  
Ulcer Healing ◽  
Alpha Lipoic Acid ◽  
Gastric Ulcer Healing

scholarly journals Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5287
Author(s):  
Syed Mohammed Basheeruddin Asdaq ◽  
Earla Swathi ◽  
Sunil S Dhamanigi ◽  
Mohammed Asad ◽  
Yahya Ali Mohzari ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Daucus Carota ◽  
Ulcer Healing ◽  
Gastric Ulcers ◽  
Chronic Gastric Ulcer ◽  
Experimental Animals ◽  
Pylorus Ligation

The carrot plant (Daucus carota) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethacin-induced gastric ulcer models were used to evaluate the ulcer healing effect. Carrot fruit (500 mg/kg) and its co-administration with pantoprazole produced significant protection in an ethanol- and stress-induced acute gastric ulcer and cysteamine-induced duodenal ulcer. The healing of the acetic acid-induced chronic gastric ulcer was also augmented with this combination. Both total proteins and mucin contents were significantly increased in indomethacin-induced gastric ulcers. Similarly, in pylorus ligation, the pepsin content of gastric juice, total acidity, and free acidity were reduced. Overall, both ulcer preventive effects and ulcer healing properties of the pantoprazole were significantly enhanced in animals who received the co-administration of carrot fruit (500 mg/kg).

scholarly journals Accelerated Ulcer Healing and Resistance to Ulcer Recurrence with Gastroprotectants in Rat Model of Acetic Acid-induced Gastric Ulcer

2008 ◽  
Vol 42 (3) ◽  
pp. 204-214 ◽  
Author(s):  
Tae Young Oh ◽  
Byung Ok Ahn ◽  
Eun Jung Jang ◽  
Joo Sang Park ◽  
Sang Jong Park ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Rat Model ◽  
Ulcer Healing ◽  
Ulcer Recurrence
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