scholarly journals Intraoperative Squash Smear in Central Nervous System Tumors and Its Correlation with Histopathology: 1 Year Study at a Tertiary Care Centre

2017 ◽  
Vol 08 (02) ◽  
pp. 221-224 ◽  
Author(s):  
Arpita Jindal ◽  
Himanshi Diwan ◽  
Kanwalpreet Kaur ◽  
V. D. Sinha
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Partial Correlation ◽  
Tertiary Care ◽  
Central Nervous System Tumors ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Reliable Technique ◽  
Hematoxylin And Eosin ◽  
Time Of Operation

ABSTRACT Background: Intraoperative squash smear cytology is a simple and reliable technique for rapid intraoperative diagnosis of neurosurgical specimens. The study was designed to assess the accuracy of intraoperative squash smear in the diagnosis of central nervous system (CNS) space-occupying lesions. Materials and Methods: One hundred and fifty cases of CNS space-occupying lesion were studied in a period of 15 months. Smears were prepared from the biopsy sample obtained at the time of operation and were stained with rapid hematoxylin and eosin method. Results: One hundred and forty-one cases showed complete correlation with histopathology, two cases showed partial correlation, and seven cases were discrepant. The overall diagnostic accuracy was found to be 94%. Conclusion: Intraoperative squash smear thus provides diagnosis with fair accuracy in brain tumors and is of great value in intraoperative consultation.

Central nervous system hemangioblastomas: Epidemiology, pathology and clinical spectrum in a tertiary care centre

Astrocyte ◽  
2014 ◽  
Vol 1 (3) ◽  
pp. 186 ◽  
Author(s):  
SanjayM Chawhan ◽  
AartiA Dani ◽  
SarojA Meshram ◽  
ShilpaM Narkhede ◽  
ArchanaA Randale ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tertiary Care ◽  
Clinical Spectrum ◽  
Care Centre ◽  
Tertiary Care Centre

scholarly journals Central Nervous System Tuberculosis: Clinical Characteristics and Outcome. A Saudi Tertiary Care Centre Experience

2015 ◽  
Vol 05 (01) ◽  
pp. 63-71
Author(s):  
Mohammad Bo Saeed ◽  
Adel Alothman ◽  
Suleiman Kojan ◽  
Suliman Almahmoud ◽  
Ali Al Khathaami ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Characteristics ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

scholarly journals HISTOLOGICAL SPECTRUM OF CENTRAL NERVOUS SYSTEM TUMOURS– A STUDY AT A TERTIARY CARE CENTRE IN BIHAR

2017 ◽  
Vol 6 (18) ◽  
pp. 1421-1424
Author(s):  
Anju Singh ◽  
Reecha Singh ◽  
Monalisa Monalisa ◽  
Anuj Singh K ◽  
Arika Singh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Central Nervous System Tumours

scholarly journals Role of Voriconazole in the Management of Invasive Central Nervous System Aspergillosis: A Case Series from a Tertiary Care Centre in India

2020 ◽  
Vol 6 (3) ◽  
pp. 139 ◽  
Author(s):  
Nitin Gupta ◽  
Parul Kodan ◽  
Ankit Mittal ◽  
Gagandeep Singh ◽  
George Netto ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Median Duration ◽  
Tertiary Care ◽  
Case Series ◽  
North India ◽  
Cns Infection ◽  
Tertiary Care Centre ◽  
Diagnostic Modalities

Invasive central nervous system (CNS) aspergillosis is acquired by either hematogenous dissemination or direct spread from a sinus infection. We describe a series of nine patients with CNS aspergillosis from a tertiary care teaching institute in North India who were treated with voriconazole alone or in combination with surgery. All patients who had clinical and radiological features consistent with fungal CNS infection, showed the presence of septate hyphae on histopathology/microscopy and were either culture positive for Aspergillus spp. or had serum galactomannan positivity were diagnosed as CNS aspergillosis. Clinical features, risk factors, diagnostic modalities, treatment details and outcome at last follow-up were recorded for all patients diagnosed with CNS aspergillosis. A total of nine patients were diagnosed with CNS aspergillosis. The median duration of presentation at our hospital was six months (IQR-2-9 months). Six patients had concomitant sinus involvement, while two patients had skull-base involvement as well. All patients were treated with voriconazole therapy, and three of these patients underwent surgery. All but one patient survived at the last follow-up (median duration was 14 months (IQR- 8-21.5). Two patients had complete resolution, and voriconazole was stopped at the last follow-up, and the rest of the patients were continued on voriconazole. Of the six patients who were continued on voriconazole, all but one had more than 50% radiological resolution on follow-up imaging. Invasive CNS aspergillosis is an important cause of CNS fungal infection that is often diagnosed late and requires long-term voriconazole-based therapy.

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