Toxicological screening

Herein, we reported unique optical and electrochemical properties of citrate-stabilized gold nanoparticles (AuNPs) as a probe for smartphone-assisted, on-spot detection of codeine sulphate in toxicological screening with high sensitivity (0.9 μM).

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5 Statistics as Applied to Pharmacological and Toxicological Screening

Progress in Medicinal Chemistry ◽

10.1016/s0079-6468(08)70119-x ◽

1963 ◽

pp. 187-260 ◽

Cited By ~ 1

Author(s):

G.A. Stewart ◽

P.A. Young

Keyword(s):

Toxicological Screening

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Detection of intrauterine illicit drug exposure by newborn drug testing

Clinical Chemistry ◽

10.1093/clinchem/43.1.235 ◽

1997 ◽

Vol 43 (1) ◽

pp. 235-242 ◽

Cited By ~ 49

Author(s):

Tai C Kwong ◽

Rita M Ryan

Keyword(s):

Social Services ◽

Drug Testing ◽

Drug Exposure ◽

Illicit Drug ◽

Developmental Stages ◽

Gastric Lavage ◽

Toxicological Screening ◽

Time Required ◽

Urine Testing

Abstract Identification of intrauterine drug-exposed newborns with toxicological screening may have benefits including close follow-up of the infant by both medical and social services. Applying specific written guidelines to select newborns for drug testing decreases bias and protects the physicians and hospitals involved. All drugs reported as positive should be confirmed by an appropriate second test. Urine and meconium testing are the best current options for identifying drug-exposed neonates. Urine testing sensitivity is low because of problems encountered in urine collections and the high thresholds used in current urine assays. The disadvantage to meconium testing is the increased labor and time required to work with this material. Testing of newborn hair is unlikely to be widely used until technically less demanding assays become available. Testing of amniotic fluid or gastric lavage is still in the developmental stages. Adopting lower urine assay thresholds for newborn samples would increase sensitivity and would be an appropriate modification of current methodologies.

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Toxicological screening and DNA sequencing detects contamination and adulteration in regulated herbal medicines and supplements for diet, weight loss and cardiovascular health

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2019.112834 ◽

2019 ◽

Vol 176 ◽

pp. 112834 ◽

Cited By ~ 7

Author(s):

Elly Crighton ◽

Megan L. Coghlan ◽

Rachael Farrington ◽

Claire L. Hoban ◽

Matthew W.P. Power ◽

...

Keyword(s):

Weight Loss ◽

Dna Sequencing ◽

Cardiovascular Health ◽

Herbal Medicines ◽

Toxicological Screening

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Assessment of a soil with moderate level of contamination using lettuce seed assay and terrestrial isopods assimilation assay

Soil and Water Research ◽

10.17221/28/2012-swr ◽

2013 ◽

Vol 8 (No. 2) ◽

pp. 56-62 ◽

Cited By ~ 6

Author(s):

F.M.R. Da Silva Júnior ◽

E.M. Garcia ◽

R.M. Baisch ◽

N. Mirlean ◽

A.L. Muccillo-Baisch

Keyword(s):

Contaminated Soils ◽

Consumption Rate ◽

Assimilation Efficiency ◽

Soil Samples ◽

Toxicity Tests ◽

Lettuce Seed ◽

Toxicological Screening ◽

Terrestrial Isopods ◽

Wet Weight ◽

Feeding Parameters

Lettuce (Lactuca sativa) seeds play a significant role in toxicity tests of isolated chemicals, pesticides, and environmental samples. Commonly, the main variables under study are the rate of seed germination and root elongation at the end of five days of exposure. Another organisms used in environmental assessment of soil quality are terrestrial isopods. The parameter evaluated in this assay is usually mortality rate. In this study, we suggest to use the daily number of germinated seeds and wet weight of plants, and feeding measurements (consumption rate, assimilation rate, assimilation efficiency and growth rate) in woodlice (Armadillidium vulgare and Porcellio dilatatus) to detect toxicity of moderately contaminated soil samples. The lettuce seed assay proved to be more efficient in the tested conditions, however, we do not reject the use of feeding parameters in terrestrial isopods in toxicological screening of contaminated soils.

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