A smart and rapid colorimetric method for the detection of codeine sulphate, using unmodified gold nanoprobe

RSC Advances ◽  
2014 ◽  
Vol 4 (92) ◽  
pp. 50443-50448 ◽  
Author(s):  
Anand Lodha ◽  
Alok Pandya ◽  
Pinkesh G. Sutariya ◽  
Shobhana K. Menon
Keyword(s):  
Gold Nanoparticles ◽  
Electrochemical Properties ◽  
Colorimetric Method ◽  
High Sensitivity ◽  
Toxicological Screening ◽  
Spot Detection ◽  
Gold Nanoprobe

Herein, we reported unique optical and electrochemical properties of citrate-stabilized gold nanoparticles (AuNPs) as a probe for smartphone-assisted, on-spot detection of codeine sulphate in toxicological screening with high sensitivity (0.9 μM).

scholarly journals X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

2021 ◽  
Vol 22 (7) ◽  
pp. 3691
Author(s):  
Oliver Schmutzler ◽  
Sebastian Graf ◽  
Nils Behm ◽  
Wael Y. Mansour ◽  
Florian Blumendorf ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Irradiation Time ◽  
High Sensitivity ◽  
Nanoparticle Uptake ◽  
X Ray ◽  
Functionalized Gold Nanoparticles ◽  
Uptake Measurement ◽  
Prostate Tumor Cells ◽  
Non Destructive

Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time.

A colorimetric method for the determination of xanthine based on the aggregation of gold nanoparticles

2014 ◽  
Vol 182 (1-2) ◽  
pp. 395-400 ◽  
Author(s):  
Wendan Pu ◽  
Huawen Zhao ◽  
Liping Wu ◽  
Xianying Zhao
Keyword(s):  
Gold Nanoparticles ◽  
Colorimetric Method

scholarly journals A simple and sensitive sensor for silver ions based on unmodified gold nanoparticles by using dynamic light scattering techniques

2017 ◽  
Vol 95 (12) ◽  
pp. 1267-1272 ◽  
Author(s):  
Zhiyou Xiao ◽  
Anjiang Tang ◽  
Hongsheng Huang ◽  
Ze Wang
Keyword(s):  
Gold Nanoparticles ◽  
Light Scattering ◽  
Dynamic Light Scattering ◽  
High Sensitivity ◽  
Silver Ions ◽  
Hydrodynamic Diameter ◽  
Optimum Conditions ◽  
Sensitivity And Selectivity ◽  
Sensitive Sensor ◽  
Average Hydrodynamic Diameter

A simple and sensitive assay for Ag+ was developed with unmodified gold nanoparticles (AuNPs) by using dynamic light scattering techniques. Ag+ could induce the oligonucleotide (5′-ATC ACT ATA TCA TAT ACT CAT-3′) to change from a single-stranded structure to a double-stranded structure and desorb from the surface of AuNPs, which triggered the aggregation of AuNPs in the salt solution. The average hydrodynamic diameter of aggregated AuNPs could be detected by using dynamic light scattering techniques. Under the optimum conditions, the average hydrodynamic diameter of AuNPs is proportional to the concentration of Ag+ within the range of 13.3–100.0 nmol/L, with a detection limit of 3.2 nmol/L. The method is easy to operate and has low sample consumption, high sensitivity and selectivity.

A Simple Colorimetric Method for Naked-Eye Detection of Circulating Cell-Free DNA Using Unlabelled Gold Nanoparticles

2018 ◽  
Vol 3 (41) ◽  
pp. 11541-11551 ◽  
Author(s):  
Shweta Khanna ◽  
Prasanta Padhan ◽  
Sourav Das ◽  
Kumar Sagar Jaiswal ◽  
Archana Tripathy ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Colorimetric Method ◽  
Eye Detection ◽  
Cell Free Dna ◽  
Naked Eye ◽  
Free Dna ◽  
Naked Eye Detection ◽  
Circulating Cell Free Dna

Simple and Cost Effective Polymer Modified Gold Nanoparticles Based on Colorimetric Determination of L-Cysteine in Food Samples

2021 ◽  
Vol 34 (1) ◽  
pp. 41-57
Author(s):  
Beeta Rani Khalkho ◽  
Anushree Saha ◽  
Bhuneshwari Sahu ◽  
Manas Kanti Deb
Keyword(s):  
Gold Nanoparticles ◽  
High Sensitivity ◽  
Cost Effective ◽  
Food Samples ◽  
Colorimetric Determination ◽  
Plasmon Resonance Band ◽  
Transmission Electron ◽  
Resonance Band ◽  
Absorbance Band

Abstract. The purpose of the present research was to design a method for the colorimetric determination of L-cysteine. We have employed PVA capped gold nanoparticles (GNPs) as a probe. The as-synthesized GNPs were further characterized by UV-vis absorption spectroscopy, transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and Zeta potential analyser. The results show that the presence of L-cysteine caused the quenching of the surface plasmon resonance band of the GNPs at 524 nm. It was accompanied by the appearance of a new absorbance of a new absorbance band at 670 nm. The color of the colloidal GNPs changed from wine red to blue. The change in color of the GNPs was due to their aggregation induced by the presence of L-cysteine. Based on these observations, the as-synthesized GNPs were utilized to develop a novel colorimetric sensor for L-cysteine detection in food samples. Significantly, other biomolecules such as alanine, proline, phenylalanine, tryptophane, valine, arginine, glutamic acid, lysine and histidine did not cause any change in the color of the GNPs solutions. This colorimetric probe showed excellent selectivity and high sensitivity for L-cysteine with a detection limit of 2.0 μg mL-1.

High Sensitivity Detection of Gene-like Tumor Markers Based on SERS Characteristics of Hollow Sea-urchin Gold Nanoparticles and Noble Metal/semiconductor Substrate

2020 ◽  
Vol 49 (8) ◽  
pp. 817002-817002
Author(s):  
彭乐 Le PENG ◽  
周露 Lu ZHOU ◽  
卿艳平 Yan-ping QING ◽  
佟丽莹 Li-ying TONG ◽  
梁照恒 Zhao-heng LIANG ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Tumor Markers ◽  
Noble Metal ◽  
Sea Urchin ◽  
High Sensitivity ◽  
Semiconductor Substrate ◽  
High Sensitivity Detection ◽  
Sensitivity Detection

scholarly journals Functionalized Gold Nanoparticles as Contrast Agents for Proton and Dual Proton/Fluorine MRI

Nanomaterials ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 879 ◽  
Author(s):  
Maria Şologan ◽  
Francesco Padelli ◽  
Isabella Giachetti ◽  
Domenico Aquino ◽  
Mariangela Boccalon ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Gold Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Sensitivity ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gold Core ◽  
19F Magnetic Resonance Imaging

Gold nanoparticles carrying fluorinated ligands in their monolayer are, by themselves, contrast agents for 19F magnetic resonance imaging displaying high sensitivity because of the high density of fluorine nuclei achievable by grafting suitable ligands on the gold core surface. Functionalization of these nanoparticles with Gd(III) chelates allows adding a further functional activity to these systems, developing materials also acting as contrast agents for proton magnetic resonance imaging. These dual mode contrast agents may allow capitalizing on the benefits of 1H and 19F magnetic resonance imaging in a single diagnostic session. In this work, we describe a proof of principle of this approach by studying these nanoparticles in a high field preclinical scanner. The Gd(III) centers within the nanoparticles monolayer shorten considerably the 19F T1 of the ligands but, nevertheless, these systems display strong and sharp NMR signals which allow recording good quality 19F MRI phantom images at nanoparticle concentration of 20 mg/mL after proper adjustment of the imaging sequence. The Gd(III) centers also influence the T1 relaxation time of the water protons and high quality 1H MRI images could be obtained. Gold nanoparticles protected by hydrogenated ligands and decorated with Gd(III) chelates are reported for comparison as 1H MRI contrast agents.

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