scholarly journals Disseminated skeletal muscle and cardiac metastasis from squamous cell carcinoma of the lung detected with FDG and FLT PET/CT

2016 ◽  
Vol 15 (3) ◽  
pp. 215
Author(s):  
RajenderKumar Basher ◽  
TarunKumar Jain ◽  
SampannaJung Rayamajhi ◽  
Dheeraj Gupta ◽  
VenkataNagarjuna Maturu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cardiac Metastasis ◽  
Flt Pet ◽  
Pet Ct

Cardiac metastasis in a patient with oral squamous cell carcinoma

2021 ◽  
Vol 14 (9) ◽  
pp. e244844
Author(s):  
Benjamin Denoiseux ◽  
Philippe Van Camp ◽  
Michel Bila ◽  
Constantinus Politis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cardiac Metastasis ◽  
Second Primary ◽  
Positron Emission ◽  
Pet Ct ◽  
Left Base ◽  
Base Of The Tongue

A 55-year-old man initially presented with an undifferentiated, HPV-p16-negative squamous cell carcinoma (SCC) in the left tonsillar region (cT4a N0 M0), which was treated with a combination of radiotherapy and chemotherapy. Several months later, the patient developed osteoradionecrosis on the left side of the mandible as well as a second primary lesion at the left base of the tongue. Surgical resection and mandibular reconstruction with a free vascularised fibula flap was performed. Regional clinical and radiologic follow-up showed no signs of tumour recurrence. However, routine positron emission tomography (PET)-CT showed a hypermetabolic mass intracardially. MRI confirmed the presence of a mass intramurally in the left ventricle, highly indicative of metastasis. Cardiac metastasis following oral cancer is rare and usually asymptomatic. Therefore, it can be missed easily and is mostly described as a finding postmortem. Reporting these cases is important for contributing to the insight into the uncommon development of metastasis.

The Appearance of Cardiac Metastasis From Squamous Cell Carcinoma of the Lung on F-18 FDG PET/CT and Post Hoc PET/MRI

2011 ◽  
Vol 36 (4) ◽  
pp. 311-312 ◽  
Author(s):  
Stephan Probst ◽  
Alexandra Seltzer ◽  
Bradley Spieler ◽  
Abraham Chachoua ◽  
Kent Friedman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Cardiac Metastasis ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Post Hoc

Compare the diagnostic value of FLT and FDG PET/CT in assessment of regional lymph nodes in thoracic esophageal squamous cell carcinoma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15620-e15620
Author(s):  
D. HanJ. Yu ◽  
X. Zhong ◽  
D. Mu ◽  
Z. Fu ◽  
B. Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Flt Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

e15620 Background: To determine whether FLT PET/CT can detect regional lymph nodes metastases in untreated thoracic esophageal squamous cell carcinoma. In view of the reported high sensitivity of FDG PET/CT for the evaluation of thoracic nodules of esophageal carcinoma, we additionally performed FDG PET/CT for direct comparison with that of FLT. Methods: From March 2008 to December 2008, 18 patients with thoracic esophageal squamous cell carcinoma underwent dual-tracer PET/CT examinations before surgery. The results of reviewing side-by-side FDG PET/CT and FLT PET/CT images for the diagnosis of locoregional lymph node metastases were compared prospectively in relation to pathologic findings. The PET images were visually inspected with the maximum standardized uptake value (SUVmax) determined from a circular region of interest (ROI) over the entire lesion. The differential threshold for malignancy was set as SUVFDG≥2.5, and SUVFLT≥1.4, respectively. Results: All patients underwent esophagectomy and lymphadenectomy, and pathologic examination confirmed nodes positive for metastasis in 14 patients and 42 of 344 excised nodes. The uptake of FDG (median SUVmax, 5.59; range, 2.5–10.6) in locoregional lymph nodes metastasis was significantly higher than that of FLT (median SUVmax, 2.93; range, 1.6–4.6). There were 14 false positive nodes in FDG PET and only 3 in FLT PET, 7 false negative nodes in FDG PET, while 11 false negative nodes in FLT PET. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FLT PET/CT were 73.81%, 99.01%, 95.93%, 91.18% and 96.45%, respectively, whereas those of FDG PET/CT were 83.33%, 95.36%, 93.90%, 71.43% and 95.36%, respectively. P values were 0.425, 0.014, 0.298, 0.055, and 0.541, respectively. Conclusions: FLT uptake in regional lymph node of esophageal carcinoma is significantly lower compared with FDG uptake.FLT PET has fewer false-positive findings compared with FDG PET. The specificity of FLT PET/CT is higher than that of FDG. We suggest that esophageal carcinoma N-staging need to combine FLT with FDG PET/CT images. No significant financial relationships to disclose.

scholarly journals Squamous cell carcinoma of the tongue with cardiac metastasis on 18F-FDG PET/CT

Medicine ◽  
2021 ◽  
Vol 100 (15) ◽  
pp. e25529
Author(s):  
Pierre Delabie ◽  
Diane Evrard ◽  
Ilyass Zouhry ◽  
Phalla Ou ◽  
François Rouzet ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Cardiac Metastasis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Carcinoma Of The Tongue

scholarly journals Textural Features of Pretreatment 18F-FDG PET/CT Images: Prognostic Significance in Patients with Advanced T-Stage Oropharyngeal Squamous Cell Carcinoma

2013 ◽  
Vol 54 (10) ◽  
pp. 1703-1709 ◽  
Author(s):  
N.-M. Cheng ◽  
Y.-H. Dean Fang ◽  
J. Tung-Chieh Chang ◽  
C.-G. Huang ◽  
D.-L. Tsan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Prognostic Significance ◽  
Ct Images ◽  
Textural Features ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Bladder squamous cell carcinoma in a pregnant woman: case report and review of the literature

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Pablo A. Rojas ◽  
Cristián González ◽  
Gonzalo P. Mendez ◽  
Alejandro Majerson ◽  
Ignacio F. San Francisco
Keyword(s):  
Squamous Cell Carcinoma ◽  
Bladder Cancer ◽  
Pregnant Woman ◽  
Urinary Tract ◽  
Cell Carcinoma ◽  
Radical Cystectomy ◽  
Squamous Cell ◽  
Pet Ct ◽  
Cell Bladder Cancer ◽  
Urinary Tract Reconstruction

Abstract Background Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. Case presentation We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. Conclusions Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.

scholarly journals Implications of Standardized Uptake Values of Oral Squamous Cell Carcinoma in PET-CT on Prognosis, Tumor Characteristics and Mitochondrial DNA Heteroplasmy

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2273
Author(s):  
Lukas Latzko ◽  
Bernd Schöpf ◽  
Hansi Weissensteiner ◽  
Federica Fazzini ◽  
Liane Fendt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Mitochondrial Dna ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Tumor Characteristics ◽  
Dna Mutations ◽  
Standardized Uptake Values ◽  
Pet Ct

Under aerobic conditions, some cancers switch to glycolysis to cover their energy requirements. Taking advantage of this process, functional imaging techniques such as PET-CT can be used to detect and assess tumorous tissues. The aim of this study was to investigate standardized uptake values and mitochondrial DNA mutations in oral squamous cell carcinoma. A cohort of 57 patients underwent 18[F]FDG-PET-CT and standardized uptake values were collected. In 15 patients, data on mitochondrial DNA mutations of the tumor were available. Kaplan–Meier curves were calculated, and correlation analyses as well as univariate Cox proportional hazard models were performed. Using ROC analysis to determine a statistical threshold for SUVmax in PET investigations, a cut-off value was determined at 9.765 MB/mL. Survival analysis for SUVmax in these groups showed a Hazard Ratio of 4 (95% CI 1.7–9) in the high SUVmax group with 5-year survival rates of 23.5% (p = 0.00042). For SUVmax and clinicopathological tumor features, significant correlations were found. A tendency towards higher mtDNA heteroplasmy levels in high SUVmax groups could be observed. We were able to confirm the prognostic value of SUVmax in OSCC, showing higher survival rates at lower SUVmax levels. Correlations between SUVmax and distinct tumor characteristics were highly significant, providing evidence that SUVmax may act as a reliable diagnostic parameter. Correlation analysis of mtDNA mutations suggests an influence on metabolic activity in OSCC.

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