scholarly journals Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling

2022 ◽  
Vol 17 (6) ◽  
pp. 1172
Author(s):  
Richard Eva ◽  
Bart Nieuwenhuis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Axon Regeneration ◽  
Pi3 Kinase ◽  
Kinase Signaling ◽  
The Central Nervous System

Multifunctionalized Electrospun Silk Fibers Promote Axon Regeneration in the Central Nervous System

2011 ◽  
Vol 21 (22) ◽  
pp. 4232-4242 ◽  
Author(s):  
Corinne R. Wittmer ◽  
Thomas Claudepierre ◽  
Michael Reber ◽  
Peter Wiedemann ◽  
Jonathan A. Garlick ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Axon Regeneration ◽  
Silk Fibers ◽  
The Central Nervous System

scholarly journals mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Linqing Miao ◽  
Liu Yang ◽  
Haoliang Huang ◽  
Feisi Liang ◽  
Chen Ling ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Axon Regeneration ◽  
Nodal Point ◽  
Mtor Signaling ◽  
Negative Regulator ◽  
Molecular Dissection ◽  
Parallel Pathways ◽  
Downstream Effectors ◽  
The Central Nervous System

Injured mature CNS axons do not regenerate in mammals. Deletion of PTEN, the negative regulator of PI3K, induces CNS axon regeneration through the activation of PI3K-mTOR signaling. We have conducted an extensive molecular dissection of the cross-regulating mechanisms in axon regeneration that involve the downstream effectors of PI3K, AKT and the two mTOR complexes (mTORC1 and mTORC2). We found that the predominant AKT isoform in CNS, AKT3, induces much more robust axon regeneration than AKT1 and that activation of mTORC1 and inhibition of GSK3β are two critical parallel pathways for AKT-induced axon regeneration. Surprisingly, phosphorylation of T308 and S473 of AKT play opposite roles in GSK3β phosphorylation and inhibition, by which mTORC2 and pAKT-S473 negatively regulate axon regeneration. Thus, our study revealed a complex neuron-intrinsic balancing mechanism involving AKT as the nodal point of PI3K, mTORC1/2 and GSK3β that coordinates both positive and negative cues to regulate adult CNS axon regeneration.

scholarly journals Biomedical Applications: Multifunctionalized Electrospun Silk Fibers Promote Axon Regeneration in the Central Nervous System (Adv. Funct. Mater. 22/2011)

2011 ◽  
Vol 21 (22) ◽  
pp. 4202-4202 ◽  
Author(s):  
Corinne R. Wittmer ◽  
Thomas Claudepierre ◽  
Michael Reber ◽  
Peter Wiedemann ◽  
Jonathan A. Garlick ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biomedical Applications ◽  
Axon Regeneration ◽  
Silk Fibers ◽  
The Central Nervous System

scholarly journals Co-culture of oligodendrocytes and neurons can be used to assess drugs for axon regeneration in the central nervous system

2015 ◽  
Vol 10 (10) ◽  
pp. 1612 ◽  
Author(s):  
Xu-yi Chen ◽  
Yue Tu ◽  
Lin Gang ◽  
Yu-chen Yao ◽  
Ying-fu Liu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Axon Regeneration ◽  
The Central Nervous System

Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside

2018 ◽  
Vol 34 (1) ◽  
pp. 495-521 ◽  
Author(s):  
Michele Curcio ◽  
Frank Bradke
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Embryonic Development ◽  
Peripheral Nervous System ◽  
Axonal Transport ◽  
Axon Regeneration ◽  
Epigenetic Modifications ◽  
Cns Injury ◽  
Cytoskeletal Dynamics ◽  
The Central Nervous System

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons’ remarkable potential to grow during embryonic development and after an injury in the peripheral nervous system (PNS). Several intracellular mechanisms—including cytoskeletal dynamics, axonal transport and trafficking, signaling and transcription of regenerative programs, and epigenetic modifications—control axon regeneration. In this review, we describe how manipulation of intrinsic mechanisms elicits a regenerative response in different organisms and how strategies are implemented to form the basis of a future regenerative treatment after CNS injury.

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