Context: Gastric cancer(GC) is fth most common cancer worldwide. Mostly presents with advanced
stage and poor overall survival.
Methods: Retrospective study on clinical, pathological, pattern of distant metastasis(DM) , treatment aspect of GC treated
between January 2014 to December 2018 in a tertiary care center in south India.
Statistical analysis : Chi square test and multivariate analysis (MVA) were used for analysis. P <0.05 was considered
signicant.
Results: Median age at diagnosis is 57 years. Higher male : female ratio. Most common presentation was abdominal pain
followed vomiting. Malignant Gastric outlet obstruction(MGOO) was present in 22.7%. Histologically , all patients had
adenocarcinoma with predominantly moderate differentiation (51.1%). Liver (19.1%)was most common site of metastasis .
Curative surgery was done in 35.5% of patients. D2 lymph node dissection was performed in 12.4% of patient. Patients were
given perioperative /preoperative/ adjuvant / palliative chemotherapy. MVA revealed history of tobacco use, body of stomach
tumor location, nodal disease were risk factors for DM.
Conclusion : The present analysis revealed use of tobacco, alcohol intake were main risk factors for GC. Most of the patients
present in advanced stage , so prevention by avoiding risk factors and early detection by signs , symptoms and endoscopy are
necessary. Use of tobacco,site of tumor location, nodal disease were factors associated with DM. Aggressive management with
both surgery and chemotherapy is warranted for locally advanced disease.
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