A comparative study on the clinical and polysomnographic pattern of obstructive sleep apnea among obese and non-obese subjects

AbstractObstructive sleep apnea syndrome (OSAS) is characterized by symptoms and signs of more than 5 apneas per hour (AHI) at polysomnography or 15 or more apneas per hour without symptoms. In this review, the focus will be a subgroup of patients: adult non-obese subjects with OSA and their specific features. In non-obese OSA patients (patients with BMI < 30 kg/m2), there are specific polysomnographic features which reflect specific pathophysiological traits. Previous authors identified an anatomical factor (cranial anatomical factors, retrognatia, etc.) in OSA non-obese. We have hypothesized that in this subgroup of patients, there could be a non-anatomical pathological prevalent trait. Little evidence exists regarding the role of low arousal threshold. This factor could explain the difficulty in treating OSA in non-obese patients and emphasizes the importance of a specific therapeutic approach for each patient.

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Screening obstructive sleep apnea-hypopnea syndrome in hypertensive patients: a comparative study of the efficiency of the Epworth sleepiness scale

BMC Pulmonary Medicine ◽

10.1186/s12890-018-0737-y ◽

2018 ◽

Vol 18 (1) ◽

Author(s):

Florent Seguro ◽

Vincent Bard ◽

Kamila Sedkaoui ◽

Maya Riche ◽

Alain Didier ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Comparative Study ◽

Epworth Sleepiness Scale ◽

Hypertensive Patients ◽

Obstructive Sleep ◽

Hypopnea Syndrome

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The association of NOV/CCN3 with obstructive sleep apnea (OSA): preliminary evidence of a novel biomarker in OSA

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2017-0029 ◽

2017 ◽

Vol 31 (2) ◽

Cited By ~ 3

Author(s):

Jeremy A. Weingarten ◽

Lars Bellner ◽

Stephen J. Peterson ◽

Moe Zaw ◽

Puja Chadha ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Matrix Protein ◽

Strong Association ◽

Preliminary Evidence ◽

Extracellular Matrix Protein ◽

Morbidly Obese ◽

Potential Marker ◽

Obstructive Sleep ◽

Obese Subjects

AbstractObstructive sleep apnea (OSA) has a strong association with cardiovascular and metabolic abnormalities, although the mechanism driving this association is not well established. NOV/CCN3, a multifunctional extracellular matrix protein, may play a mechanistic and/or prognostic role in these associations. We hypothesized that patients with OSA, which primarily affects obese individuals, will have increased levels of NOV, and that NOV can serve as a biomarker in patients to predict OSA as well as metabolic and cardiac risk. Ten morbidly obese and 10 healthy lean subjects underwent overnight polysomnography (PSG) and clinical evaluation. Blood samples were analyzed for NOV levels, adiponectin and IL-6. OSA was found in nine obese subjects and three lean subjects. NOV levels were significantly higher in the OSA vs. no OSA group (2.1 ± 0.9 vs. 1.3 ± 0.8, p < 0.03). NOV levels were significantly higher in the obese vs. lean group (2.2 ± 0.3 vs. 1.4 ± 0.2-fold change, p < 0.03). Among lean subjects, NOV levels were significantly higher in the OSA vs. no OSA group (2.1 ± 0.9 vs. 1.0 ± 0.4, p < 0.05). NOV and AHI were positively correlated (ρ = 0.49, p = 0.033). IL-6 and adiponectin differences in obese vs. lean and OSA vs. no OSA were consistent with an inflammatory phenotype in obese subjects and OSA subjects. NOV is a novel biomarker of the presence and severity of OSA and a potential marker of future cardiovascular and metabolic disease in OSA patients.

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