scholarly journals The circulating midkine in the newly diagnosed celiac disease: Clinical implications

2021 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
Mohsen Masjedi ◽  
MohammadHassan Emami ◽  
Shima Soltani ◽  
Nahid Eskandari
Keyword(s):  
Celiac Disease ◽  
Clinical Implications ◽  
Newly Diagnosed

scholarly journals Efficient implementation of the ‘non-biopsy approach’ for the diagnosis of childhood celiac disease in the Netherlands: a national prospective evaluation 2010–2013

2021 ◽  
Author(s):  
Caroline R. Meijer ◽  
Joachim J. Schweizer ◽  
Anne Peeters ◽  
Hein Putter ◽  
M. Luisa Mearin
Keyword(s):  
Celiac Disease ◽  
The Netherlands ◽  
Clinical Presentation ◽  
Paediatric Population ◽  
Hla Typing ◽  
Newly Diagnosed ◽  
Prospective Evaluation ◽  
Espghan Guidelines ◽  
Intestinal Symptoms ◽  
Nationwide Implementation

AbstractThe aim of this study was (1) to prospectively evaluate the nationwide implementation of the ESPGHAN-guidelines for the diagnosis of celiac disease (CD), (2) to investigate the incidence and clinical presentation of diagnosed childhood CD (0–14 years) in the Netherlands, and (3) to compare the findings with national survey data from 1975 to 1990 and 1993 to 2000 using the same approach. From 2010 to 2013, all practicing paediatricians were invited to report new celiac diagnoses to the Dutch Pediatric Surveillance Unit. Data were collected via questionnaires. A total of 1107 children with newly diagnosed CD were reported (mean age, 5.8 years; range, 10 months–14.9 years; 60.5% female). After the introduction of the non-biopsy approach in 2012, 75% of the diagnoses were made according to the guideline with a significant decrease of 46.3% in biopsies. The use of EMA and HLA-typing significantly increased with 25.8% and 62.1%, respectively. The overall incidence rate of childhood CD was 8.8-fold higher than in 1975–1990 and 2.0-fold higher than in 1993–2000. During the study period, the prevalence of diagnosed CD was 0.14%, far below 0.7% of CD identified via screening in the general Dutch paediatric population. Clinical presentation has shifted towards less severe and extra-intestinal symptoms.Conclusion: ESPGHAN guidelines for CD diagnosis in children were effectively and rapidly implemented in the Netherlands. Incidence of diagnosed CD among children is still significantly rising with a continuous changing clinical presentation. Despite the increasing incidence of diagnoses, significant underdiagnosis still remains. What is Known:• Since 2000 the incidence of diagnosed childhood CD in the Netherlands has shown a steady rise.• The rise in incidence has been accompanied by a changing clinical presentation at diagnosis. What is New:• The ESPGHAN guidelines 2012 for CD diagnosis were effectively and rapidly implemented in the Netherlands.• The incidence of diagnosed childhood CD in the Netherlands has continued to rise significantly during the reported period.

scholarly journals The Prevalence of Anti-Zein Antibodies: A Comparative Study between Celiac Disease and Irritable Bowel Syndrome

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 649
Author(s):  
Luis Alberto Sánchez-Vargas ◽  
Karina Guadalupe Hernández-Flores ◽  
Francisco Javier Cabrera-Jorge ◽  
José María Remes-Troche ◽  
Job Reyes-Huerta ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Gastrointestinal Disorder ◽  
Newly Diagnosed ◽  
Disease Group ◽  
Immune Mediated ◽  
Healthy Control ◽  
Gliadin Peptides ◽  
Irritable Bowel ◽  
First Time

Celiac disease (CD) is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals. In contrast, irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder affecting the large intestine, without an autoimmune component. Here, we evaluated the prevalence of IgA and IgG antibodies to maize zeins (AZA) in patients with CD and IBS. Using an in-house ELISA assay, the IgA and IgG anti-zein antibodies in the serum of 37 newly diagnosed CD (16 biopsy proved and 21 serological diagnosis) and 375 IBS patients or 302 healthy control (HC) subjects were measured. Elevated levels of IgA AZA were found in CD patients compared with IBS patients (p < 0.01) and HC (p < 0.05). CD patients had the highest prevalence (35.1%), followed by IBS (4.3%) and HCs (2.3%) (p < 0.0001). IgG AZA antibodies were not found in any CD patients, IBS patients, or HC subjects. A significant positive correlation was found between IgA AZA with IgA anti-gliadin (AGA, r = 0.34, p < 0.01) and IgA anti-deaminated gliadin peptides (DGP, r = 0.42, p < 0.001) in the celiac disease group. Taken together, our results show for the first time a higher prevalence of AZA IgA antibodies in newly diagnosed CD patients than in IBS patients, confirming a biased immune response to other gliadin-related prolamins such as maize zeins in genetically susceptible individuals.

Circulating Extracellular Vesicles, A Novel Mechanism of Endocrine Cellular Cross-Talk, are Increased in Newly Diagnosed Celiac Disease Patients

2017 ◽  
Vol 152 (5) ◽  
pp. S71
Author(s):  
Konstantinos Efthymakis ◽  
Giuseppina Bologna ◽  
Paola Lanuti ◽  
Angelo Milano ◽  
Francesco Laterza ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Extracellular Vesicles ◽  
Cross Talk ◽  
Newly Diagnosed

The genetics of celiac disease: A comprehensive review of clinical implications

2015 ◽  
Vol 64 ◽  
pp. 26-41 ◽  
Author(s):  
Romina Dieli-Crimi ◽  
M. Carmen Cénit ◽  
Concepción Núñez
Keyword(s):  
Celiac Disease ◽  
Clinical Implications ◽  
Comprehensive Review

scholarly journals INCREASED TISSUE TRANSGLUTAMINASE LEVELS ARE ASSOCIATED WITH INCREASED EPILEPTIFORM ACTIVITY IN ELECTROENCEPHALOGRAPHY AMONG PATIENTS WITH CELIAC DISEASE

2015 ◽  
Vol 52 (4) ◽  
pp. 272-277 ◽  
Author(s):  
Sedat IŞIKAY ◽  
Şamil HIZLI ◽  
Serkan ÇOŞKUN ◽  
Kutluhan YILMAZ
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Pearson Correlation ◽  
Epileptiform Activity ◽  
Control Group ◽  
Healthy Children ◽  
Newly Diagnosed ◽  
Laboratory Findings ◽  
Significant Difference ◽  
Medical Histories

Background - Celiac disease is an autoimmune systemic disorder in genetically predisposed individuals precipitated by gluten ingestion. Objective - In this study, we aimed to determine asymptomatic spike-and-wave findings on electroencephalography in children with celiac disease. Methods - A total of 175 children with the diagnosis of celiac disease (study group) and 99 age- and sex-matched healthy children as controls (control group) were included in the study. In order to determine the effects of gluten free diet on laboratory and electroencephalography findings, the celiac group is further subdivided into two as newly-diagnosed and formerly-diagnosed patients. Medical histories of all children and laboratory findings were all recorded and neurologic statuses were evaluated. All patients underwent a sleep and awake electroencephalography. Results - Among 175 celiac disease patients included in the study, 43 were newly diagnosed while 132 were formerly-diagnosed patients. In electroencephalography evaluation of patients the epileptiform activity was determined in 4 (9.3%) of newly diagnosed and in 2 (1.5%) of formerly diagnosed patients; on the other hand the epileptiform activity was present in only 1 (1.0%) of control cases. There was a statistically significant difference between groups in regards to the presence of epileptiform activity in electroencephalography. Pearson correlation analysis revealed that epileptiform activity in both sleep and awake electroencephalography were positively correlated with tissue transglutaminase levels (P=0.014 and P=0.019, respectively). Conclusion - We have determined an increased epileptiform activity frequency among newly-diagnosed celiac disease patients compared with formerly-diagnosed celiac disease patients and control cases. Moreover the tissue transglutaminase levels were also correlated with the presence of epileptiform activity in electroencephalography. Among newly diagnosed celiac disease patients, clinicians should be aware of this association and be alert about any neurological symptoms.

Silent Celiac Disease Is Frequent in the Siblings of Newly Diagnosed Celiac Patients

Digestion ◽  
2007 ◽  
Vol 75 (4) ◽  
pp. 182-187 ◽  
Author(s):  
Maria Teresa Bardella ◽  
Luca Elli ◽  
Pietro Velio ◽  
Clara Fredella ◽  
Luigia Prampolini ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Newly Diagnosed

Hypertransaminasemia in Newly Diagnosed Pediatric Patients With Celiac Disease

2016 ◽  
Vol 63 (3) ◽  
pp. 340-343 ◽  
Author(s):  
Grace J. Lee ◽  
Brendan Boyle ◽  
Tracy Ediger ◽  
Ivor Hill
Keyword(s):  
Celiac Disease ◽  
Pediatric Patients ◽  
Newly Diagnosed

The Effect of Gluten-free Diet on Cardiovascular Risk Factors in Newly Diagnosed Pediatric Celiac Disease Patients

2019 ◽  
Vol 68 (5) ◽  
pp. 684-688 ◽  
Author(s):  
Eyal Zifman ◽  
Orith Waisbourd-Zinman ◽  
Luba Marderfeld ◽  
Noam Zevit ◽  
Anat Guz-Mark ◽  
...  
Keyword(s):  
Risk Factors ◽  
Celiac Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Newly Diagnosed

scholarly journals Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

EBioMedicine ◽  
2020 ◽  
Vol 56 ◽  
pp. 102807 ◽  
Author(s):  
Stefan Bittner ◽  
Falk Steffen ◽  
Timo Uphaus ◽  
Muthuraman Muthuraman ◽  
Vinzenz Fleischer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Implications ◽  
Newly Diagnosed ◽  
Multicentre Cohort Study ◽  
Multicentre Cohort
Sign in / Sign up

Export Citation Format

Share Document