scholarly journals Detection of rare blood group Ax phenotype in blood donor

Author(s):  
P.M. Bala Bhasker ◽  
Rakesh Kumar ◽  
Romesh Jain ◽  
Avineesh Chandra
Keyword(s):  
2019 ◽  
Vol 47 (4) ◽  
pp. 279-287
Author(s):  
Genghis H. Lopez ◽  
Brett Wilson ◽  
Robyn M. Turner ◽  
Glenda M. Millard ◽  
Nicole S. Fraser ◽  
...  

Background: MNS blood group system genes GYPA and GYPB share a high degree of sequence homology and gene structure. Homologous exchanges between GYPA and GYPB form hybrid genes encoding hybrid glycophorins GP(A-B-A) and GP(B-A-B). Over 20 hybrid glycophorins have been characterised. Each has a distinct phenotype defined by the profile of antigens expressed including Mia. Seven hybrid glycophorins carry Mia and have been reported in Caucasian and Asian population groups. In Australia, the population is diverse; however, the prevalence of hybrid glycophorins in the population has never been determined. The aims of this study were to determine the frequency of Mia and to classify Mia-positive hybrid glycophorins in an Australian blood donor population. Method: Blood samples from 5,098 Australian blood donors were randomly selected and screened for Mia using anti-Mia monoclonal antibody (CBC-172) by standard haemagglutination technique. Mia-positive red blood cells (RBCs) were further characterised using a panel of phenotyping reagents. Genotyping by high-resolution melting analysis and DNA sequencing were used to confirm serology. Result: RBCs from 11/5,098 samples were Mia-positive, representing a frequency of 0.22%. Serological and molecular typing identified four types of Mia-positive hybrid glycophorins: GP.Hut (n = 2), GP.Vw (n = 3), GP.Mur (n = 5), and 1 GP.Bun (n = 1). GP.Mur was the most common. Conclusion: This is the first comprehensive study on the frequency of Mia and types of hybrid glycophorins present in an Australian blood donor population. The demographics of Australia are diverse and ever-changing. Knowing the blood group profile in a population is essential to manage transfusion needs.


Transfusion ◽  
2017 ◽  
Vol 57 (12) ◽  
pp. 2914-2919 ◽  
Author(s):  
Andreas S. Rigas ◽  
Adam A. Berkfors ◽  
Ole B. Pedersen ◽  
Erik Sørensen ◽  
Kaspar R. Nielsen ◽  
...  
Keyword(s):  

Author(s):  
Nurmalia PS ◽  
Purwanto AP ◽  
Julia Julia

Transfusion reactions in the thrombocyte concentrate (TC) manual is often associated with the storage time due to the release of cytokines by leukocytes during storage. The results showed the majority of transfusion reactions include fever/febrile non-haemolytic transfusion reaction (FNHTR). The quality control of blood components is necessary for the determination a component of blood in the bag already qualified for or not for transfusion. The aims of this study is to determine the residual leukocytes in the TC manual of Blood Donor Unit (UDD) at PMI Semarang with the shelf life of 3−5 days in compliance with the requirements of TC quality criteria of the European Union Council (EU).A Descriptive study is conducted at the Blood Donor Unit (UDD) PMI Semarang. The TC sample consist of 30 bags and manuals from the transfusion bag, which has been stored between 3−5 days. The examination of the residual leukocytes from the TC bag is carried out by manual microscopic method as well as the counting. The results obtained from the O blood group are 13 bags (43%) of TC, the B blood group seven (7) bags (33%), A blood group two bags (7%), and AB five (5) bags (17%). The range of the residual values of white blood cells in the TC manual is from 0 up to 0.0086×109/unit. According to the EU Council of leukocytes in the TC control value is <0.2×109/unit. The results of the residual leukocytes in the TC manual with the shelf life of 3−5 days are in accordance with the quality standards. This results indicates that the residual leukocytes in the TC manual UDD PMI Semarang in accordance with the EU quality standards.


2012 ◽  
Vol 39 (6) ◽  
pp. 477-479 ◽  
Author(s):  
Z. A. Randriamanantany ◽  
D. H. Rajaonatahina ◽  
F. E. Razafimanantsoa ◽  
M. T. Rasamindrakotroka ◽  
R. Andriamahenina ◽  
...  

2018 ◽  
Vol 7 (31) ◽  
pp. 3445-3447
Author(s):  
Arpita Chatterjee Halder ◽  
Alpana De ◽  
Saibendu Kumar Lahiri

2016 ◽  
Vol 24 (1) ◽  
pp. 53-56
Author(s):  
Shanaz Karim ◽  
Md Mazharul Hoque ◽  
Ehteshamul Hoque ◽  
Hussne Ara Begum ◽  
Syeda Masooma Rahman ◽  
...  

Objective: This study was aimed to identify the distribution patterns of ABO and Rh-D blood group among the blood donor attending at transfusion medicine department DMCHin order to promote social awareness and safe blood transfusion among the population.Method: It was a cross sectional study conducted in the Department of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, from January to December 2014. After proper ethical consideration, a total of 39,512 blood donors were included in this study. They were selected irrespective of age and sex by systematic random sampling. ABO and Rh-D blood groups were determined by the antigen antibody agglutination test in our blood bank by standard tile techniques.Results: Among 39,512 blood donors male blood donors were 31,602(79.98%), female blood donors were 7,910(20.01%).14,817(37.5%) blood donor were identified as having blood group B, while 12,565 (31.8%) were blood group O, 8614( 21.80%) and3516( 8.9% )were blood group A and AB respectively. Rh-D positive were 38,247(96.79%) and Rh-D negative were 1,265(3.2%).J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 53-56


Author(s):  
Danish Khan

A blood bank is a place where we grater blood as a result of blood donation, stored and preserved for later use in blood transfusion no doubt. There are many online web-based blood bank management systems to satisfy the requirement of donor and receivers. There we are going to modify the existing System as this paper includes the key features, merits and demerits in existing web-based blood bank. This study shows the comparison between various existing systems and provides more idea to improve the existing system In this paper, we present s “Life Treasure Blood Portal” that is a based-on java. To develop this system, we are using different kind of technology, like html, Ajax, JSP, CSS, bootstrap, Servlet , Java-Script, JDBC. This system will monitor the record of blood donation in real-time and given the analytical report like which city has more number of blood donor, which any has more number of blood receiver which blood group is more donated etc. So, there I am going to introduce this system and in at the end I will conclude.


2018 ◽  
Vol 13 (1) ◽  
pp. 12 ◽  
Author(s):  
Christ-Dominique Ngassaki-Yoka ◽  
Jophrette Mireille Ntsame Ndong ◽  
Cyrille Bisseye

Background: Few studies focused on the study of blood groups in Gabon. This study aimed to determine the phenotypic frequency of ABO and Rhesus antigens in blood donors of Libreville and to assess the association between ABO blood groups and transfusion-transmitted infections.Materials and Methods: The study of ABO and Rhesus blood groups concerned 4,744 blood donors. ABO and Rhesus phenotyping were obtained using monoclonal monospecific antisera: anti-A, anti-B, anti-AB, anti-D, anti-E, anti-C, anti-c, and anti-e with an automate (QWALYS® 3, DIAGAST, France) or a card gel (ID Card, BIO-RAD) according to manufacturer’s instructions.Results: The phenotypic frequency of blood group antigens A, B, AB and O were respectively 21.0%; 17.6%; 2.6% and 58.9%. Those of rhesus antigens D, d, C, c, E and e were 97.7%; 2.3%; 15.9%; 99.9%; 17.6%; 99.3%, respectively. The prevalence of ABO and Rh antigens in Gabonese donors reported here are significantly different from those of neighboring countries. No association was found between the prevalence of HIV, HCV and syphilis and ABO blood groups. Instead, HBV seroprevalence was twice as high among non-O blood groups donors compared with blood group O donors [OR = 2 (CI 1.26 to 3.2), p = 0.003].Conclusions: This study provides new data on phenotypic frequency of ABO and Rh blood groups in a representative sample of the Gabonese blood donor population. It suggests a significant association between ABO blood group and HBV infection.


Sign in / Sign up

Export Citation Format

Share Document