Oncological outcome following TORS in HPV negative supraglottic carcinoma

Objectives: The aim of the study was to examine the effectiveness of a modified-short hydration gemcitabine and cisplatin (m-shGC) regimen for patients with metastatic urothelial carcinoma (mUC) and to assess the efficacy of a geriatric nutritional risk index (GNRI) with regard to prognosis. Patients and Methods: From January 2016 to July 2020, 68 patients with mUC underwent first-line m-shGC therapy with 70 mg/m2 cisplatin and 1,000 mg/m2 gemcitabine (days 1, 8, and 15), with 2,050 mL fluid replaced on the first day of each 28-day cycle. Prior to the start of treatment, the serum neutrophil-to-lymphocyte ratio (NLR), and levels of albumin and C-reactive protein (CRP) in serum, as well as body heights and weights were measured. Patients were grouped according to GNRI <92 (low) or ≥92 (high). The analysis of data was done retrospectively. Results: Median follow-up was found to be 12.9 (range 1.7–50.2) months and the objective response rate (ORR) was 54.4% after m-shGC treatment. The ORR was significantly different when high and low-GNRI groups were compared (ORR: 28.0 vs. 69.8% in low- vs. high-GNRI groups). Median overall survival (OS) was calculated as 8.6 (95% confidence interval [CI]: 5.4–21.3) and 34.5 (95% CI: 20.5–NA) months for low- and high-GNRI groups, respectively (p < 0.0001). Unlike for NLR and CRP, univariate and multivariate analyses revealed that low GNRI and visceral metastases were significant prognostic factors for short OS. Conclusions: First-line m-shGC showed a survival benefit for mUC, with GNRI a useful prognostic biomarker.

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Association between R1 resection and oncological outcome in resectable gastrointestinal stromal tumors without tumor rupture: A systematic review and meta-analysis

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2021.01.032 ◽

2021 ◽

Author(s):

Meng Kong ◽

Guotao Liu ◽

Hongqing Zhuo ◽

Yingying Xin ◽

Hongyuan Chen ◽

...

Keyword(s):

Systematic Review ◽

Gastrointestinal Stromal Tumors ◽

Meta Analysis ◽

Oncological Outcome ◽

Tumor Rupture ◽

Stromal Tumors ◽

R1 Resection

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Appropriate Extent of Lymphadenectomy in Segmentectomy: A Multicenter Study

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyaa199 ◽

2020 ◽

Author(s):

Yoshinori Handa ◽

Yasuhiro Tsutani ◽

Takahiro Mimae ◽

Yoshihiro Miyata ◽

Hiroyuki Ito ◽

...

Keyword(s):

Lung Cancer ◽

Propensity Score ◽

Lymph Nodes ◽

Mediastinal Lymph Node ◽

Clinical Stage ◽

Oncological Outcome ◽

Cancer Specific Survival ◽

Lung Cancer Patients ◽

Clinical Stage Ia ◽

Group 5

Abstract Background The significance of lymphadenectomy is yet to be fully examined in segmentectomy. We compared the oncological outcomes of mediastinal lymph node dissection (LND) and hilar LND for lung cancer treated with segmentectomy via a multicenter database using propensity score-matched analysis. Methods We reviewed 357 clinical stage IA radiologically solid-dominant lung cancer patients who underwent segmentectomy with lymphadenectomy. The extent of LND was classified into systematic/lobe-specific mediastinal LND and hilar LND only groups. Postoperative results after segmentectomy with mediastinal LND (n = 179) and hilar LND (n = 178) were analyzed for all patients and their propensity score-matched pairs. Results Cancer-specific survival (CSS) and recurrence-free interval (RFI) rates for the mediastinal LND group were determined to be not significantly different compared with the hilar LND group in all non-adjusted cohorts. In the propensity score-matched cohort (129 pairs), mediastinal LND harvested more lymph nodes compared with hilar LND, and both groups had significantly different pathological stages (P = 0.015). Adjuvant chemotherapy was performed in 10 (7.8%) patients in the mediastinal LND group and 4 (3.1%) in the hilar LND group. The mediastinal LND group tended to have better prognosis than the hilar LND group (5-year CSS rates, 97.4% vs 93.2%; 5-year RFI rates, 93.5% vs 88.5%). Conclusions Mediastinal LND was found to provide more appropriate pathological staging compared with hilar LND in patients with segmentectomy by harvesting more lymph nodes. In addition, mediastinal LND might lead to better oncological outcome than hilar LND in segmentectomy.

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Robot assisted minimally invasive esophagectomy: safety, perioperative morbidity and short-term oncological outcome—a single institution experience

Journal of Robotic Surgery ◽

10.1007/s11701-021-01274-9 ◽

2021 ◽

Author(s):

Assif Iqbal Sayed ◽

Shaifali Goel ◽

Abhishek Aggarwal ◽

Shivendra Singh

Keyword(s):

Minimally Invasive ◽

Minimally Invasive Esophagectomy ◽

Oncological Outcome ◽

Single Institution ◽

Robot Assisted ◽

Short Term ◽

Perioperative Morbidity ◽

Invasive Esophagectomy

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548 Oncological outcome of sentinel lymph node mapping or comprehensive surgical staging in patients with node-negative intermediate-risk endometrial cancer

10.1136/ijgc-2020-esgo.81 ◽

2020 ◽

Author(s):

Franziska Siegenthaler ◽

Sara Imboden ◽

Michael Mueller

Keyword(s):

Endometrial Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Mapping ◽

Oncological Outcome ◽

Surgical Staging ◽

Intermediate Risk ◽

Node Negative ◽

Lymph Node Mapping

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The Presence of Small Nerve Fibers in the Tumor Microenvironment as Predictive Biomarker of Oncological Outcome Following Partial Hepatectomy for Intrahepatic Cholangiocarcinoma

Cancers ◽

10.3390/cancers13153661 ◽

2021 ◽

Vol 13 (15) ◽

pp. 3661

Author(s):

Jan Bednarsch ◽

Xiuxiang Tan ◽

Zoltan Czigany ◽

Dong Liu ◽

Sven Arke Lang ◽

...

Keyword(s):

Tumor Microenvironment ◽

Intrahepatic Cholangiocarcinoma ◽

Cox Regression ◽

Oncological Outcome ◽

Nerve Fibers ◽

Nodal Metastases ◽

Cancer Specific Survival ◽

Curative Intent ◽

Term Outcome ◽

Long Term Outcome

The oncological role of the density of nerve fibers (NFs) in the tumor microenvironment (TME) in intrahepatic cholangiocarcinoma (iCCA) remains to be determined. Therefore, data of 95 iCCA patients who underwent hepatectomy between 2010 and 2019 was analyzed regarding NFs and long-term outcome. Extensive group comparisons were carried out and the association of cancer-specific survival (CSS) and recurrence-free survival (RFS) with NFs were assessed using Cox regression models. Patients with iCCA and NFs showed a median CSS of 51 months (5-year-CSS = 47%) compared to 27 months (5-year-CSS = 21%) in patients without NFs (p = 0.043 log rank). Further, NFs (hazard ratio (HR) = 0.39, p = 0.002) and N-category (HR = 2.36, p = 0.010) were identified as independent predictors of CSS. Patients with NFs and without nodal metastases displayed a mean CSS of 89 months (5-year-CSS = 62%), while patients without NFs or with nodal metastases but not both showed a median CCS of 27 months (5-year-CSS = 25%) and patients with both positive lymph nodes and without NFs showed a median CCS of 10 months (5-year-CSS = 0%, p = 0.001 log rank). NFs in the TME are, therefore, a novel and important prognostic biomarker in iCCA patients. NFs alone and in combination with nodal status is suitable to identify iCCA patients at risk of poor oncological outcomes following curative-intent surgery.

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