scholarly journals Defining giant mandibular ameloblastomas – Is a separate clinical sub-entity warranted?

2018 ◽  
Vol 51 (02) ◽  
pp. 208-215 ◽  
Author(s):  
Aditya V. Kanoi ◽  
Tibar Banerjee ◽  
Narayanamurthy Sundaramurthy ◽  
Arindam Sarkar ◽  
Pooja Kanoi ◽  
...  
Keyword(s):  
Decision Making ◽  
Bone Defect ◽  
Medical Literature ◽  
Inclusion Criteria ◽  
Segmental Bone Defect ◽  
Exclusion Criteria ◽  
The Past ◽  
Mandibular Segment ◽  
Segmental Bone

ABSTRACT Context: The term giant mandibular ameloblastoma (GMAs) while being in popular usage in the medical literature remains largely equivocal. Although a few authors have in the past attempted to ascribe definite criteria to this entity, these are by and large arbitrary and without any benefit in decision-making or contributing to its management. Aims: The aim of this study is to propose a set of objective criteria for GMAs that can be clinically correlated and thereby aid in the management of this entity. Patients and Methods: Of a total of 16 patients with ameloblastoma of the mandible presenting at our institute from August 2012 to September 2016, 11 patients were identified as having GMAs as per the criteria proposed. Results: The defects in the mandible following segmental resection ranged from 7 to 11.5 cm in length (mean: 9.3 cm). No clinical or radiological evidence of tumour recurrence was found during a mean follow-up period of 10.7 months (range: 2–28 months). Conclusions: Defining GMA based on objective inclusion and exclusion criteria allows segregation of these lesions, thereby helping to remove ambiguity, simplify decision-making and facilitate communication among treating reconstructive surgeons. Inclusion criteria include: (i) The segmental bone defect following resection with a minimum 1 cm margin of healthy bone should exceed 6 cm (ii) The segmental bone defect should involve the central mandibular segment.

scholarly journals Engraftment of Prevascularized, Tissue Engineered Constructs in a Novel Rabbit Segmental Bone Defect Model

2015 ◽  
Vol 16 (12) ◽  
pp. 12616-12630 ◽  
Author(s):  
Alexandre Kaempfen ◽  
Atanas Todorov ◽  
Sinan Güven ◽  
René Largo ◽  
Claude Jaquiéry ◽  
...  
Keyword(s):  
Bone Defect ◽  
Segmental Bone Defect ◽  
Defect Model ◽  
Prevascularized Tissue ◽  
Segmental Bone

Preparation of porous PLA/DBM composite biomaterials and experimental research of repair rabbit radius segmental bone defect

2015 ◽  
Vol 16 (4) ◽  
pp. 615-622 ◽  
Author(s):  
Yumin Zhang ◽  
Jianru Wang ◽  
Jue Wang ◽  
Xiaojun Niu ◽  
Jianchun Liu ◽  
...  
Keyword(s):  
Bone Defect ◽  
Experimental Research ◽  
Segmental Bone Defect ◽  
Segmental Bone ◽  
Composite Biomaterials

An Analysis of Systems of Classifying Mild Cognitive Impairment in Older People

2002 ◽  
Vol 36 (1) ◽  
pp. 133-140 ◽  
Author(s):  
Alexander Collie ◽  
Paul Maruff
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Older People ◽  
Classification Systems ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Genetic Studies ◽  
The Past ◽  
Made In

Objective: Over the past two decades, a number of systems have been developed for the classification of cognitive and behavioural abnormalities in older people, in order that individuals at high risk of developing neurodegenerative disease, particularly Alzheimer's disease, may be identified well before the disease manifests clinically. This article critically examines the inclusion and exclusion criteria of a number of such classification systems, to determine the effect that variations in criterion may have on clinical, behavioural and neuroimaging outcomes reported from older people with mild cognitive impairment. Method: Qualitative review of the literature describing systems of classifying mild cognitive impairment, and outcomes from clinical, behavioural, neuroimaging and genetic studies of older people with mild cognitive impairment. Results: The exclusion and inclusion criteria for these classification systems vary markedly, as do the design of studies upon which the validity of these systems has been assessed. Minor changes to individual exclusion/inclusion criterion may result in substantial changes to estimates of the prevalence and clinical outcome of mild cognitive impairment, while inadequate experimental design may act to confound the interpretation of results. Conclusions: As a result of these factors, accurate and consistent estimates of the outcome of mild cognitive impairments in otherwise healthy older people are yet to be obtained. On the basis of this analysis of the literature, optimal criteria via which accurate classifications of mild cognitive impairment can be made in future are proposed.

scholarly journals Epidemiological study, clinical spectrum and associations of childhood vitiligo in a tertiary care centre

2016 ◽  
Vol 2 (4) ◽  
pp. 86
Author(s):  
Rangaraj Murugaiyan
Keyword(s):  
Tertiary Care ◽  
Significant Proportion ◽  
Clinical Spectrum ◽  
Age Group ◽  
Care Centre ◽  
Inclusion Criteria ◽  
Common Site ◽  
Tertiary Care Centre ◽  
Exclusion Criteria ◽  
The Past

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Childhood vitiligo is a special subtype and is seen in significant proportion of vitiligo patients. There are only a few clinical studies in the past which address the clinical spectrum of vitiligo in children. This study on eighty cases of childhood vitiligo will cover the epidemiology and clinical spectrum.</span></p><p class="abstract"><strong>Methods:</strong> To study the epidemiology, clinical spectrum and associations in childhood vitiligo. Inclusion criteria: all new cases of vitiligo in children under 12 years attending the outpatient department of Dermatology, exclusion criteria: old treated cases of vitiligo and age more than 12 years. Statistical analysis was done using mean and percentage of means.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Most common age group affected includes 4-6 years. Most common site of initial lesion was head and neck followed by upper limb, lower limb and trunk. Most common clinical type was vitiligo vulgaris followed by focal type then segmental. Lip tip type was least common type. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Childhood vitiligo is a serious issue and the knowledge of its various patterns and associations needs to be updated at regular intervals.</span></p>

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