Brief psychotic disorder during COVID-19 pandemic: A case series

A 30-year-old man with no significant previous or family psychiatric history became severely anxious about his health after a positive COVID-19 test. Physical symptoms of COVID-19 were mild, with no evidence of hypoxia or pneumonia, throughout his illness. He was admitted to a quarantine facility. He remained highly anxious, and 1 week later, he developed paranoid delusions and auditory hallucinations (his first psychotic episode). He was treated with lorazepam 1 mg four times a day, mirtazapine 30 mg nocte and risperidone 1 mg two times a day. His psychotic symptoms lasted 1 week. He stopped psychiatric medication after 4 weeks and had remained well when reviewed 3 months later. A Diagnostic and Statistical Manual of Mental Disorders fifth edition diagnosis of brief psychotic disorder with marked stressor (brief reactive psychosis) was made. Anxiety about his health and social isolation appeared the main aetiological factors but an inflammatory component cannot be excluded. The case highlights that first episode psychosis can be associated with mild COVID-19.

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Cannabis-related psychotic disorder upon relapse to cannabis use: A case series and possible neurobiological implications

Asian Journal of Psychiatry ◽

10.1016/j.ajp.2018.03.003 ◽

2018 ◽

Vol 33 ◽

pp. 42-44 ◽

Cited By ~ 1

Author(s):

Balaji Bharadwaj ◽

Karthick Navin ◽

Pooja Patnaik Kuppili

Keyword(s):

Psychotic Disorder ◽

Case Series ◽

Cannabis Use

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Brief psychotic disorder during COVID-19 infection: Marked stressor or neuropsychiatric symptoms?

Current Psychiatry Research and Reviews ◽

10.2174/2666082217666211007154908 ◽

2021 ◽

Vol 17 ◽

Author(s):

Jalal Doufik ◽

Said Boujraf ◽

Mina Ouhmou ◽

Hicham Laaraj ◽

Khalid Mouhadi ◽

...

Keyword(s):

Psychotic Disorder ◽

Neuropsychiatric Symptoms ◽

Stress Factor ◽

Positive Patient ◽

World Health ◽

Acute Psychosis ◽

Symptomatic Infection ◽

Brief Psychotic Disorder ◽

Coronavirus Infection ◽

Health Organization

Background: COVID-19 virus outbreak appeared in December 2019 and was announced as pandemic by the World Health Organization (WHO) in March 2020. Recent cases of reactive psychosis in the context of the COVID-19 pandemic have been reported. However, there was reduced interest attributed to cases of acute psychosis affecting patients with COVID-19. In here, we present a clinical case of a female patient who showed a brief psychotic disorder during a symptomatic infection with COVID-19. Methods: We discuss the differential diagnosis of brief psychotic disorder with marked stressor and neuropsychiatric symptoms of COVID-19 infection. Although the stress factor appeared to be linked to the acute psychosis onset in our COVID-19 positive patient, the diagnosis of a psychotic disorder due to the viral coronavirus infection is worthing to be reported and discussed. Results and Conclusion: The stress factor appears to be linked to the onset of acute psychosis in this COVID-19 positive patient, the diagnosis of a psychotic disorder due to the viral coronavirus infection is worth to be mentioned. Thus, we suggest that a new psychosis case associated with COVID-19 infection due to potential immune-mediated neuropathogenesis that would justify further investigation. Through this case report, we highlight the need for vigilant monitoring of neuropsychiatric symptoms in individuals with COVID-19 infections.

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Overview of Schizophrenia and Other Psychotic Disorders

10.2310/psych.13011 ◽

2020 ◽

Author(s):

James A. Wilcox ◽

Donald W. Black

Keyword(s):

Psychotic Disorder ◽

Schizoaffective Disorder ◽

Psychotic Disorders ◽

Public Health Problem ◽

Premature Death ◽

Major Public Health Problem ◽

Schizophreniform Disorder ◽

Schizophrenia Spectrum ◽

Brief Psychotic Disorder ◽

The Individual

Psychotic disorders are among the most disabling conditions and constitute a major public health problem. Described throughout recorded time, they affect as many as 5% of the population and cause a disproportionate amount of suffering and loss to society. In the chapter on schizophrenia spectrum and other psychotic disorders, the DSM-5 lists delusional disorder, brief psychotic disorder, schizophreniform disorder, schizophrenia, and schizoaffective disorder, as well as categories for substance- or medically induced psychotic disorders. The term psychosis indicates that the individual has a severe inability to interpret the surrounding environment in a realistic way. Symptoms include hallucinations, delusions, and bizarre behavior. Psychotic disorders are associated with premature death, mostly attributable to suicide. The pathophysiology and etiology of psychotic disorders are only now beginning to be understood, and treatment for these conditions remains suboptimal. Researchers are currently refining the cause of these symptoms and developing more effective treatments. This review contains 3 tables, and 34 references. Key words: Brief psychotic disorder, delusions, hallucinations, psychosis, schizoaffective disorder, schizophrenia, schizophreniform disorder

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Regional brain volumes in brief psychotic disorder

Journal of Neural Transmission ◽

10.1007/s00702-020-02140-y ◽

2020 ◽

Vol 127 (3) ◽

pp. 371-378

Author(s):

Hua Li ◽

Szabolcs Kéri

Keyword(s):

Psychotic Disorder ◽

Brain Volumes ◽

Regional Brain ◽

Brief Psychotic Disorder

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CYCLOID PSYCHOSIS AND BRIEF PSYCHOTIC DISORDER: A COMPARATIVE STUDY

Schizophrenia Research ◽

10.1016/j.schres.2010.02.764 ◽

2010 ◽

Vol 117 (2-3) ◽

pp. 417

Author(s):

Rafael Rodríguez ◽

Alba Roca ◽

Cristina Pujol ◽

Irene Ramos ◽

Sara Cardona ◽

...

Keyword(s):

Comparative Study ◽

Psychotic Disorder ◽

Cycloid Psychosis ◽

Brief Psychotic Disorder

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Diagnostic validity of ICD-10 acute and transient psychotic disorders and DSM-5 brief psychotic disorder

European Psychiatry ◽

10.1016/j.eurpsy.2017.05.028 ◽

2017 ◽

Vol 45 ◽

pp. 104-113 ◽

Cited By ~ 18

Author(s):

A.C. Castagnini ◽

P. Fusar-Poli

Keyword(s):

Psychotic Disorder ◽

Psychotic Disorders ◽

Case Identification ◽

Migrant Populations ◽

Diagnostic Categories ◽

Dsm 5 ◽

Characteristic Family ◽

Brief Psychotic Disorder ◽

Icd 10

AbstractBackground:Short-lived psychotic disorders are currently classified under “acute and transient psychotic disorders” (ATPDs) in ICD-10, and “brief psychotic disorder” (BPD) in DSM-5. This study's aim is to review the literature and address the validity of ATPDs and BPD.Method:Papers published between January 1993 and December 2016 were identified through searches in Web of Science. Reference lists in the located papers provided further sources.Results:A total of 295 articles were found and 100 were included in the review. There were only a few studies about the epidemiology, vulnerability factors, neurobiological correlates and treatment of these disorders, particularly little interest seems to exist in BPD. The available evidence suggests that short-lived psychotic disorders are rare conditions and more often affect women in early to middle adulthood. They also are neither associated with premorbid dysfunctions nor characteristic family predisposition, while there seems to be greater evidence of environmental factors particularly in developing countries and migrant populations. Follow-up studies report a favourable clinical and functional outcome, but case identification has proved difficult owing to high rates of transition mainly either to schizophrenia and related disorders or, to a lesser extent, affective disorders over the short- and longer-terms.Conclusions:Although the lack of neurobiological findings and little predictive power argue against the validity of the above diagnostic categories, it is important that they are kept apart from longer-lasting psychotic disorders both for clinical practice and research. Close overlap between ATPDs and BPD could enhance the understanding of these conditions.

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COVID-19-associated brief psychotic disorder

BMJ Case Reports ◽

10.1136/bcr-2020-236940 ◽

2020 ◽

Vol 13 (8) ◽

pp. e236940 ◽

Cited By ~ 7

Author(s):

Colin M Smith ◽

Jonathan R Komisar ◽

Ahmad Mourad ◽

Brian R Kincaid

Keyword(s):

Mental Illness ◽

Family History ◽

Psychotic Disorder ◽

Neuropsychiatric Symptoms ◽

Healthy Woman ◽

Psychotic Symptoms ◽

First Case ◽

Brief Psychotic Disorder ◽

History Of ◽

New Onset

A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals.

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