Comparison of intra articular autologous platelet-rich plasma with steroids in osteoarthritis knee: Experience from a North Indian tertiary care center

Introduction: Osteoarthritis(OA) knee cases are increasing day by day and with no established cure of disease only palliative ( analgesics ) therapy is given.Platelet-rich plasma (PRP) injection aim at reducing the pain as well as causing regeneration of articular cartilage partially reversing the disease process. Methods: 49 patients with OA were given PRP injection and followed up for a period of 48 weeks . Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) wasused to evaluate the results of the study. Results: Patients showed marked improvement in symptoms after the PRP injection but patients having higher body mass index( BMI ) had relatively poorer response totherapy. Conclusion: Our study concluded that PRP injection is an effective modality in the treatment of OA knee whose long term effects are yet to be determined.

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Role of platelet-rich plasma in early osteoarthritis of knee joint: Experience from a tertiary care center in Pakistan

Journal of Orthopaedic Surgery ◽

10.1177/2309499019853953 ◽

2019 ◽

Vol 27 (2) ◽

pp. 230949901985395 ◽

Cited By ~ 1

Author(s):

Nusrat Rasheed ◽

Kamran Hafeez ◽

Itat Hussain Zaidi ◽

Raza Askari ◽

Naseem Rasheed ◽

...

Keyword(s):

Knee Joint ◽

Platelet Rich Plasma ◽

Care Center ◽

Tertiary Care ◽

Tertiary Care Center ◽

Early Osteoarthritis ◽

Osteoarthritis Of Knee ◽

Joint Experience

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A Randomised control study on effects of autologous platelet rich plasma injection in early osteoarthritis knee by single dose versus double dose regimen

Indian Journal of Orthopaedics Surgery ◽

10.18231/2395-1362.2018.0036 ◽

2018 ◽

Vol 4 (2) ◽

pp. 173-177

Keyword(s):

Single Dose ◽

Dose Regimen ◽

Platelet Rich Plasma ◽

Double Dose ◽

Early Osteoarthritis ◽

Plasma Injection ◽

Osteoarthritis Knee ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet ◽

Control Study

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A comparative study between local injection of autologous platelet rich plasma and injection of corticosteroid in functional improvement of plantar fasciitis

International Surgery Journal ◽

10.18203/2349-2902.isj20190809 ◽

2019 ◽

Vol 6 (3) ◽

pp. 653 ◽

Cited By ~ 1

Author(s):

Vithal Prakash Puri ◽

Anil Kumar Gaur

Keyword(s):

Plantar Fasciitis ◽

Platelet Rich Plasma ◽

Tertiary Care ◽

Functional Improvement ◽

Significant Difference ◽

Group A ◽

Autologous Platelet Rich Plasma ◽

Group B ◽

Autologous Platelet

Background: Plantar fasciitis is a common cause of heel pain in adults. Although it is usually a self-limiting condition, the pain may become prolonged and severe enough to cause significant distress and disruption to the patient’s daily activities and work. The primary objective of the study was to evaluate and compare the effectiveness of autologous platelet rich plasma (PRP) and steroid injections in chronic cases of plantar fasciitis (PF).Methods: A prospective, randomized study was conducted from December 2013 to December 2015 amongst 60 patients with chronic PF were randomized prospectively in single tertiary care center in India. All the patients were enrolled according to inclusion criteria and divided into 2 groups i.e. group A (n=30) received PRP and group B (n=30) received corticosteroids injections. Roles and Maudsley score (RM Score) and Foot Function Index (FFI) was evaluated for all the included patients. The follow-up scheduled at 1 and 6 months after complete enrolment of patients.Results: Between both the groups, the significant difference was observed at 1 and 6 months follow-up from the baseline. At 1-month follow-up, statistically significant improvement in mean RM scores were seen in both the groups from baseline and when RM scores were compared between two groups, group B had statistically better mean scores. At 1-month follow-up there was no statistically significant difference between the mean FFI score values between two groups. At 6-month follow-up, statistically significant improvement in mean FFI scores were seen in both the groups, however when both groups were compared to each other, improvement in mean FFI scores was statistically better in group A as compared to group B.Conclusions: The present study concluded the use of PRP in chronic cases of plantar fasciitis seems more safe and effective in long term than the traditional treatment of steroid injection at different time period.

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A Study of the Efficacy of Microneedling with Topical Autologous Platelet Rich Plasma in the Treatment of Acne Scars in a Tertiary Care Centre

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v7i10.27 ◽

2019 ◽

Vol 7 (10) ◽

Author(s):

Priyadharsini R ◽

Keyword(s):

Platelet Rich Plasma ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre ◽

Acne Scars ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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Intralesional autologous platelet rich plasma therapy in chronic nonhealing cutaneous ulcers: an interventional study from a tertiary care centre in North Kerala

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20185080 ◽

2019 ◽

Vol 5 (1) ◽

pp. 116

Author(s):

V. P. K. Gopinath ◽

V. M. Simi ◽

K. Basheer Ahammed ◽

P. M. Farisa ◽

C. M. Ali Rishad

Keyword(s):

Platelet Rich Plasma ◽

Financial Burden ◽

Tertiary Care ◽

Tertiary Care Centre ◽

Plasma Therapy ◽

Venous Ulcers ◽

Before And After ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet ◽

Area And Volume

Background: Treatment of chronic nonhealing cutaneous ulcers is a challenge to clinicians. When wounds fail to achieve sufficient healing after 4 weeks of conventional therapy reassess the underlying pathology and consider advanced therapeutic options. Autologous platelet rich plasma is a novel treatment for nonhealing cutaneous ulcers, which can provide growth factors directly onto the wound.Methods: 34 patients with non-healing cutaneous ulcers satisfying inclusion and exclusion criteria were included in the study. All patients were treated with PRP therapy weekly for 6 weeks. Every week ulcer area and volume was measured and outcome expressed as improvement in area and volume of ulcers before and after PRP therapy.Results: In our study majority were males (64%) and the mean age of population was 51.0±10.4 years. Of 34 patients 18 had venous ulcers. All ulcers healed within 12 weeks and mean duration of healing was 7.51±2.9 weeks. 8 (24.24%) patients had their ulcer completely healed within 6 weeks. Larger ulcers took long duration to heal and smaller ones healed within short duration. The total improvement in area and volume of ulcers was 85.7% and 90.7% (median) respectively at the end of 6 weeks.Conclusions: PRP is an effective, safe, readily available and cheap outpatient procedure which can be widely used for the treatment of chronic recalcitrant ulcers which improves the quality of life and reduces the financial burden of patients. Further research and controlled, randomized prospective clinical trials on larger population are necessary to validate the results.

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