scholarly journals FUNCTIONAL OUTCOME OF PLATELET-RICH PLASMA INJECTIONS GIVEN IN OSTEOARTHRITIS KNEE IN TERTIARY CARE CENTER

2021 ◽  
Vol 9 (5) ◽  
pp. 667-670
Author(s):  
Gagandeep Singh Raina ◽  
◽  
Gagandeep Singh ◽  
Sanjeev Gupta ◽  
◽  
...  
Keyword(s):  
Marked Improvement ◽  
Platelet Rich Plasma ◽  
Care Center ◽  
Tertiary Care ◽  
Disease Process ◽  
Long Term Effects ◽  
Osteoarthritis Knee ◽  
Study Results ◽  
Day By Day

Introduction: Osteoarthritis(OA) knee cases are increasing day by day and with no established cure of disease only palliative ( analgesics ) therapy is given.Platelet-rich plasma (PRP) injection aim at reducing the pain as well as causing regeneration of articular cartilage partially reversing the disease process. Methods: 49 patients with OA were given PRP injection and followed up for a period of 48 weeks . Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) wasused to evaluate the results of the study. Results: Patients showed marked improvement in symptoms after the PRP injection but patients having higher body mass index( BMI ) had relatively poorer response totherapy. Conclusion: Our study concluded that PRP injection is an effective modality in the treatment of OA knee whose long term effects are yet to be determined.

Long term effects of the less than total thyroidectomy: The experience of a tertiary care center

2017 ◽  
Author(s):  
Georgios Boutzios ◽  
Zoe Garoufalia ◽  
Krystallenia Alexandraki ◽  
Gregory Kaltsas ◽  
Grigorios Kouraklis ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Long Term Effects

Comparative Study of Efficacy between Platelet-rich Plasma vs Corticosteroid Injection in the Treatment of Lateral Epicondylitis

2017 ◽  
Vol 3 (1) ◽  
pp. 1-5
Author(s):  
KM Gopinath ◽  
Madhuram Chowdry ◽  
BNR Kumar ◽  
TR Kanmani
Keyword(s):  
Comparative Study ◽  
Steroid Injection ◽  
Tennis Elbow ◽  
Platelet Rich Plasma ◽  
Corticosteroid Injection ◽  
Tertiary Care ◽  
Disease Process ◽  
Lateral Epicondylitis ◽  
Care Hospital

ABSTRACT Introduction Tennis elbow is a common condition with unpromising several modalities of treatment. Many of these are not aimed at treating the disease process. Platelet-rich plasma (PRP) contains biological healing factors and shows promising results in tendinopathies. In this study, our aim was to evaluate the efficacy of autologous PRP vs steroid injection in the treatment of chronic recalcitrant lateral epicondylitis. Materials and methods A prospective randomized control trial was conducted in our tertiary care hospital. Sixty patients with chronic lateral humeral epicondylitis, not responding to oral medications, tennis elbow belt, and physiotherapy, aged between 18 and 60 years were included in the study. Patients were randomized into PRP or steroid injection group based on a computer-generated block randomization chart. All patients had a baseline assessment including visual analog pain scores, Disability assessment of Shoulder and Hand score (DASH), and Nirschl (Injury, Prevention, Cure and Care – Nirschl Pain Phase Scale of Athletic Overuse Injuries) scores, and the same was repeated at 2 weeks, 6 weeks, 3 months, and 6 months postintervention. Results Steroid treatment shows better outcome in short-term (p < 0.001) and PRP shows better outcome in long-term (p < 0.001) follow-up. All three scores – visual analog score (VAS), DASH, Nirschl – showed significant linear improvement with PRP treatment, whereas with steroid injection initially there was significant improvement up to 3 months and later recurrence of symptoms. No complications were noted with PRP injection. Conclusion Use of autologous PRP injections for the management of lateral epicondylitis has better long-term outcomes compared with steroid injection in terms of VAS, DASH, and Nirschl scores. Also in our trial we had no recurrence of symptoms in the PRP group, whereas pain recurred in six patients in steroid group and was treated successfully with PRP. How to cite this article Chowdry M, Gopinath KM, Kumar BNR, Kanmani TR. Comparative Study of Efficacy between Platelet-rich Plasma vs Corticosteroid Injection in the Treatment of Lateral Epicondylitis. J Med Sci 2017;3(1):1-5.

Nephrocalcinosis, Renal Dysfunction, and Calculi in Patients With Primary Hypoparathyroidism on Long-Term Conventional Therapy

2020 ◽  
Vol 105 (4) ◽  
pp. e1215-e1224 ◽  
Author(s):  
Soma Saha ◽  
Devasenathipathy Kandasamy ◽  
Raju Sharma ◽  
Chandrasekhar Bal ◽  
Vishnubhatla Sreenivas ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Conventional Therapy ◽  
Care Center ◽  
Tertiary Care ◽  
Fractional Excretion ◽  
Renal Calculi ◽  
Serum Total Calcium ◽  
Calcium Phosphorus

Abstract Context There are concerns about the long-term safety of conventional therapy on renal health in patients with hypoparathyroidism. Careful audit of these would help comparisons with upcoming parathyroid hormone therapy. Objective We investigated nephrocalcinosis, renal dysfunction, and calculi, their predictors and progression over long-term follow-up in patients with primary hypoparathyroidism (PH). Design and Setting An observational study at a tertiary care center was conducted. Participants and Methods A total of 165 PH patients receiving conventional therapy were evaluated by radiographs, ultrasonography, and computed tomography. Their glomerular filtration rate (GFR) was measured by Tc-99m-diethylenetriamine penta-acetic acid clearance. Clinical characteristics, serum total calcium, phosphorus, creatinine, hypercalciuria, and fractional excretion of phosphorus (FEPh) at presentation and during follow-up were analyzed as possible predictors of renal complications. Controls were 165 apparently healthy individuals. Results Nephrocalcinosis was present in 6.7% of PH patients but not in controls. Patients younger than 15 years at presentation and with higher serum calcium-phosphorus product were at higher risk. Nephrocalcinosis showed no significant association with cataract and intracranial calcification. Prevalence of renal calculi was comparable between hypoparathyroid patients and controls (5% vs 3.6%, P = .58). Fourteen percent of patients had a GFR less than 60 mL/min/1.73 m2. Increased FEPh during follow-up was the significant predictor of low GFR. Nephrocalcinosis developed in 9% of patients over 10 years of conventional therapy. Conclusion A total of 6.7% of PH patients had nephrocalcinosis, and 14% showed renal dysfunction. Prevalence of renal calculi was similar in patients and controls. Nine percent of patients developed nephrocalcinosis over 10 years of conventional therapy.

Penile fracture: Tertiary care center experience and long‐term complications after immediate repair

Andrology ◽  
2021 ◽  
Author(s):  
Emre Bulbul ◽  
Mehmet Hamza Gultekin ◽  
Sinharib Citgez ◽  
Engin Derekoylu ◽  
Muhammet Demirbilek ◽  
...  
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Penile Fracture

scholarly journals A study on chronic otitis media in tertiary care center

2018 ◽  
Vol 4 (2) ◽  
pp. 455
Author(s):  
Leena Rajam K. ◽  
Vikram V. J. ◽  
Priyanka C. ◽  
Indumathi R.
Keyword(s):  
Hearing Loss ◽  
Temporal Bone ◽  
Otitis Media ◽  
Care Center ◽  
Tertiary Care ◽  
Disease Process ◽  
Chronic Otitis Media ◽  
Common Finding ◽  
Duration Of Symptoms ◽  
Female Patients

<p class="abstract"><strong>Background:</strong> Chronic otitis media (COM) is a serious healthcare concern worldwide, because of the distress and economic burden to the patient and their family. Temporal bone pneumatization plays an important role in etiology, behaviour, course and outcome of COM. Pneumatisation gets poorer with growing chronicity of the disease<span lang="EN-IN">. </span></p><p class="abstract"><strong>Methods:</strong> A retrospective study was conducted between March 2015-March 2017 on female patients visiting with COM, at ENT department Kasturba Gandhi Hospital, Madras Medical College. The records were analysed of the age, duration of symptoms, associated complaints, pure tone audiogram, computerised tomography of temporal bone, mastoid surgery done according to the disease process affecting the ear<span lang="EN-IN">.  </span></p><p class="abstract"><strong>Results:</strong> 35 female COM patients were analysed, most common age group is between 31-40 years in 14 patients. There hearing loss was mild category in 27. There were 27 cases of mucosal type of chronic otitis media and 8 cases of squamous type. The CT scan with sclerosis of mastoid was the common finding<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> In exclusive study on female patients with COM, the mucosal type of COM is common with mild hearing loss and sclerosed mastoid indicating the chronicity<span lang="EN-IN">.</span></p><p class="abstract"> </p>

COMPARATIVE STUDY OF E-STRIP AND VITEK 2 FOR VANCOMYCIN MIC FOR STAPHYLOCOCCUS AUREUS AT TERTIARY CARE CENTER

2021 ◽  
pp. 8-10
Author(s):  
Gauri Thakare ◽  
Sonal Chavan ◽  
Sharmila Raut ◽  
Rajani Tore ◽  
Ravindra Khadse
Keyword(s):  
Staphylococcus Aureus ◽  
Comparative Study ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Care Center ◽  
Tertiary Care ◽  
Test Material ◽  
Methicillin Resistant ◽  
Study Results ◽  
Vitek 2 ◽  
Strip Test

PURPOSE: Comparative Study done for Vancomycin susceptibility in Methicillin Resistant Staphylococcus aureus (MRSA) in two methods Vitek-2 and E-strip test. MATERIAL AND METHOD: Vancomycin susceptibility testing was performed on these Methicillin Resistant Staphylococcus aureus (MRSA) isolates by two methods viz. Vitek 2 & E- strip Test. RESULT: A total of 10680 various specimens were received and processed in laboratory. 210 samples were S. aureus amongst which 76 were MRSAs. Pus was the predominant sample followed by endotracheal secretions, blood, and sputum. All the strains of MRSA found susceptible to vancomycin (MIC≤ 2µg/ ml) by both the methods. Maximum specimens by both the methods had MICs of 1.0 µg/ ml. CONCLUSION: In the present study results of Vitek and E-strip were almost comparable. In the advanced era of automation and computerized technology with manpower compromised labs, Vitek could be a better option for vancomycin MIC.

scholarly journals Endoscopic Endonasal Odontoidectomy with Nasopharyngeal Flap Reconstruction

2020 ◽  
Author(s):  
Nyall R. London ◽  
Ahmed Mohyeldin ◽  
Ricardo L. Carrau ◽  
Daniel M. Prevedello
Keyword(s):  
High Speed ◽  
Care Center ◽  
Tertiary Care ◽  
Odontoid Process ◽  
Basilar Invagination ◽  
Cervical Fusion ◽  
Endoscopic Endonasal ◽  
Mucosal Flap ◽  
Anatomic Localization

Abstract Objective This study aimed to demonstrate the nuances in preoperative management, surgical technique, and reconstruction for an endoscopic endonasal odontoidectomy. Design Assembly of an operative video demonstrating technique for endoscopic endonasal odontoidectomy. Setting this study is a comprehensive skull base team at a tertiary care center. Participant The patient is a 53-year-old male, with basilar invagination and myelopathy, who underwent cervical fusion, 6 years back, without ventral decompression at an outside hospital. He presented to our clinic with persistent myelopathy and generalized weakness, thus an endoscopic endonasal odontoidectomy for brainstem decompression was recommended. Main Outcome Measures Preoperative computed tomography (CT) angiography and intraoperative CT navigation demonstrated normal carotid artery anatomic localization. An inverted U-shaped mucosal flap was reflected inferiorly and preserved. The C1 arch was identified and resected with a high speed drill. The resultant diseased soft tissue arising from retropulsion of the odontoid process was then removed and the odontoid process identified. This bone was removed centrally until a thin cap remained. After removal of the cap, the underlying ligamentous tissue was removed until dural pulsations were appreciated and brainstem decompression achieved. Hemostasis was attained and the mucosal flap mobilized into position. Results Postoperative CT imaging demonstrated resolution of basilar invagination and brainstem decompression (Fig. 1). The patient improved both in arm dexterity and ambulation after surgery and the reconstruction demonstrated appropriate healing on nasal endoscopy 2 months postoperatively. Conclusions This operative video demonstrates nuances in endoscopic endonasal odontoidectomy. This case also demonstrates that ventral decompression after long-term cervical fusion can improve myelopathy and that fusion in the setting of bony ventral compression, rather than rheumatoid panus, may not reduce over time with fusion only.The link to the video can be found at: https://youtu.be/370FFuBA89Y.

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