Comparison of donepezil and riluzole in improving spatial memory of male Wistar rats

2019 ◽  
Vol 8 (2) ◽  
pp. 211
Author(s):  
Mojtaba Ziaee ◽  
Sina Andalib ◽  
Faezeh Mozafari ◽  
Reza Hosseini ◽  
Mahdieh Anoush
Keyword(s):  
Spatial Memory ◽  
Wistar Rats ◽  
Male Wistar Rats

The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats

2011 ◽  
Vol 222 (1) ◽  
pp. 141-150 ◽  
Author(s):  
Alper Karakaş ◽  
Hamit Coşkun ◽  
Aliye Kaya ◽  
Ayşegül Kücük ◽  
Bülent Gündüz
Keyword(s):  
Spatial Memory ◽  
Wistar Rats ◽  
Memory Performance ◽  
Male Wistar Rats

scholarly journals Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Napatr Sriraksa ◽  
Jintanaporn Wattanathorn ◽  
Supaporn Muchimapura ◽  
Somsak Tiamkao ◽  
Kamoltip Brown ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Rat Model ◽  
Wistar Rats ◽  
Once Daily ◽  
Enhancing Effect ◽  
Neuron Density ◽  
Male Wistar Rats ◽  
6 Hydroxydopamine

Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200–250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

Offline consolidation of spatial memory: Do the cerebellar output circuits play a role? A study utilizing a Morris water maze protocol in male Wistar rats

2019 ◽  
Vol 1718 ◽  
pp. 148-158 ◽  
Author(s):  
P. Andre ◽  
M. Zaccaroni ◽  
P. Fiorenzani ◽  
D. Della Seta ◽  
M. Menzocchi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Morris Water Maze ◽  
Water Maze ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Aerobic exercise combined with environmental enrichment improves spatial memory and enhances neuroligin 1 expression: an animal study

2019 ◽  
Vol 28 (3) ◽  
pp. 228-33
Author(s):  
Faizah Abdullah Djawas ◽  
Sri Redjeki ◽  
Ria Kodariah ◽  
Neng Tine Kartinah
Keyword(s):  
Spatial Memory ◽  
Aerobic Exercise ◽  
Wistar Rats ◽  
Environmental Enrichment ◽  
Structural Changes ◽  
Escape Latency ◽  
Control Group ◽  
Hippocampal Region ◽  
Positive Effects ◽  
Male Wistar Rats

BACKGROUND Numerous studies have revealed that aerobic exercise (AE) or environmental enrichment (EE) exert positive effects on the molecular, cellular, and structural changes responsible for functional plasticity. Therefore, this study was aimed to investigate whether the combination of AE and EE yields a greater effect on spatial memory and increases the expression of the adhesion molecule neuroligin 1 compared with either of the therapies alone. METHODS Twenty 6-month-old male Wistar rats were randomly divided into four groups: (1) the control group (C), (2) the AE group, (3) the EE group, and (4) the AE-EE group. Escape latency in a Water-E-maze (WEM) task was used as a parameter to assess spatial memory function. Neuroligin 1 protein expression was examined via the immunohistochemistry (IHC) technique followed by IHC optical density (OD) score analysis of the CA1 hippocampal region. RESULTS Data acquired from the WEM task show that escape latency progressively decreased over time in all groups. However, animals in the AE-EE group required less time to complete the task compared with those in the control, AE, and EE groups. IHC OD scores revealed that the combination of AE and EE caused the highest expression of neuroligin 1 in the CA1 hippocampal region among the therapies studied. Statistical analysis indicated significant differences in OD score between the AE-EE and control, AE, and EE groups (p ≤ 0.001). CONCLUSIONS The combination of AE and EE rats increased neuroligin 1 expression and improved the spatial memory of male Wistar rats compared with application of either therapy alone.

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