scholarly journals Diagnostic significance of serum and salivary lipid levels in oral precancer and oral cancer

2021 ◽  
Vol 12 (2) ◽  
pp. 188
Author(s):  
Anurag Tripathi ◽  
Vandana Singh ◽  
Ranjitkumar Patil ◽  
Subash Singh ◽  
Vikram Khanna ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Lipid Levels ◽  
Diagnostic Significance ◽  
Oral Precancer

scholarly journals Evaluation of Serum Immunoglobulins (IgG, IgA, IgM) and Circulating Immune Complexes in Oral Precancer and Cancer Patients

2021 ◽  
Author(s):  
Pooja Madki ◽  
Mandya Lakshman Avinash Tejasvi ◽  
Geetha Paramkusam ◽  
Ruheena Khan ◽  
Shilpa J.
Keyword(s):  
Oral Cancer ◽  
Immune Complexes ◽  
Serum Levels ◽  
Circulating Immune Complexes ◽  
Oral Cancers ◽  
Cancer Group ◽  
Oral Precancer ◽  
Serum Iga ◽  
The Mean

Abstract Objectives The aim of the present study is to evaluate the role of immunoglobulins (IgA, IgG, and IgM) and circulating immune complexes (CIC) as tumor marker in oral cancer and precancer patients. Materials and Methods The present study was performed on 45 individuals subdivided into three groups, that is, oral precancer, oral cancer and healthy individuals, and levels of immunoglobulins, and CIC was estimated by turbidometry and ELISA method. Results In the present study, the mean serum IgA levels in oral precancer were 161.00 ( ±  118.02) mg/dL, oral cancers were 270.67 ( ±  171.44) mg/dL, and controls were 133.73 ( ±  101.31) mg/dL. Mean serum levels of IgG in oral precancer were 1,430.87 ( ±  316) mg/dL, oral cancers were 1,234.27 ( ±  365.42) mg/dL, and controls were 593.87 ( ±  323.06) mg/dL. Conclusion We found that the levels of serum IgG and IgA were elevated consistently in precancer and cancer group, and Serum IgM levels were increased only in precancer. Also, significant increase in serum CIC levels were seen in oral precancer and cancer group on comparison with control.

Oxidant-Antioxidant Status in Oral Precancer and Oral Cancer Patients

2003 ◽  
Vol 13 (1) ◽  
pp. 77-81 ◽  
Author(s):  
R. Subapriya ◽  
R. Kumaraguruparan ◽  
S. Nagini ◽  
A. Thangavelu
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Antioxidant Status ◽  
Oral Precancer ◽  
Oral Cancer Patients

scholarly journals Association of oral tumor suppressor gene deleted in oral cancer-1 (DOC-1) in progression of oral precancer to cancer

2015 ◽  
Vol 12 (1) ◽  
pp. 15-21
Author(s):  
Atul Katarkar ◽  
Leelavati Patel ◽  
Sanjit Mukherjee ◽  
Jay Gopal Ray ◽  
Pallab Kanti Haldar ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Oral Tumor ◽  
Oral Precancer

Evaluation of the Role of Salivary Transcriptome as a Diagnostic Aid in Oral Precancer (Homogeneous Leukoplakia) and Oral Cancer

2017 ◽  
Vol 5 (4) ◽  
pp. 290-293
Author(s):  
Nikhil N Diwan ◽  
Digambar Sable ◽  
Mahesh Chavan ◽  
Anagha Motgi ◽  
Shrikant Murlidharan ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Diagnostic Aid ◽  
Oral Precancer

Early Diagnosis and Prevention of Oral Cancer and Precancer: Report of Symposium III

1995 ◽  
Vol 9 (2) ◽  
pp. 134-137
Author(s):  
T.Axéll Chairman ◽  
M.C. Downer
Keyword(s):  
Oral Cancer ◽  
Iron Deficiency ◽  
Lichen Planus ◽  
Mental Stress ◽  
Malignant Potential ◽  
Stress Factors ◽  
Oral Precancer ◽  
Excessive Consumption ◽  
Submucous Fibrosis ◽  
Immunological System

Oral precancer encompasses several conditions and lesions. Among those entities included in the concept are leukoplakia, erythroplakia, lichen planus, and submucous fibrosis. For prevention, knowledge about etiologic and pathogenetic factors is imperative. It is well-known that excessive consumption of tobacco and alcohol has a bearing on the development of oral leukoplakia and probably also of erythroplakia. However, among leukoplakias, the idiopathic or cryptogenic type probably shows the most serious malignant potential. Involved in the development of such lesions may be general nutritional aspects, e.g., proper utilization of vitamin A. It is also well-known that iron deficiency has been linked to Plummer-Vinson's syndrome, showing a precancerous trait. Among factors involved in the pathogenesis of lichen planus is probably mental stress. Thus, stress factors and related neurological components have been linked to the immunological system. Lifestyle factors, such as nutrition, tobacco, and alcohol, and also mental environment may be of importance for the development of oral precancer and cancer.

scholarly journals Assessment of Knowledge, Awareness and Attitude towards Oral Precancer and Cancer among Narikuravar Population in Pondicherry State

2021 ◽  
Author(s):  
Sivaramakrishnan Muthanandam ◽  
Bontha V. Babu ◽  
Jananni Muthu ◽  
R. Suganya ◽  
N. Vezhavendhan ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Treatment Options ◽  
Mouth Opening ◽  
Oral Health Status ◽  
Primary Objective ◽  
Chewing Tobacco ◽  
National Programme ◽  
Oral Precancer ◽  
Hygiene Measures ◽  
And Control

Abstract Objective Literature revealed that oral health status and awareness about oral hygiene measures of Narikuravar tribes were very poor. There was also an increased prevalence of tobacco usage among this population. Considering this, incidence and prevalence of oral precancerous and cancerous lesions are expected to be high in this population. Surprisingly, the literature search revealed a lack of data on the awareness, knowledge, and prevalence of oral cancer and precancer in this group. The primary objective of this survey is to assess knowledge, awareness and attitude toward oral precancer and cancer among the Narikuravar tribal population in Pondicherry state. Materials and Methods This questionnaire survey is a part of the Model for Oral Cancer Eradication project conducted among the Narikuravar population in Pondicherry, which is funded by Indian Council of Medical Research (ICMR). A total of 153 participants were recruited for the survey. A prevalidated questionnaire was used for the survey. Results The results indicated that 47% of the participants were aware of what is oral precancer and cancer. As much as 62% knew that chewing tobacco causes oral cancer and 44% thought that the growth of tissue in the mouth could be a sign of oral cancer. Almost 100% did not think that the presence of a red lesion, white lesion, or limitation of mouth opening could be signs of cancer or precancer. Only 16% thought that oral cancer is preventable. Conclusion Awareness about oral cancer and precancer is inadequate among the Narikuravar population of Pondicherry. Majority of the population is not aware of the risks, signs, or treatment options of oral precancer and cancer. The National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS) identified the people’s knowledge gaps, and improving awareness is one of the strategies of the program.

scholarly journals microRNA-101 Represents an Innovative Bio-Marker in Oral Cancer Detection

2020 ◽  
Author(s):  
Lili Wang ◽  
Hongguang Song ◽  
Shiming Yang
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Roc Curve ◽  
Histological Grade ◽  
Mrna Level ◽  
Curve Analysis ◽  
Healthy Controls ◽  
Roc Curve Analysis ◽  
Diagnostic Significance ◽  
Oral Cancer Patients

Abstract Background: It had been suggested that microRNA-101 (miR-101) was involved in carcinogenesis and progression of various human tumors. The purpose of this study was to investigate the diagnostic value of miR-101 in oral cancer.Methods: Quantitative real-time polymerase chain reaction (QRT-PCR) was used to detect the serum mRNA level of miR-101 in 130 oral cancer cases and 82 healthy individuals. The association of miR-101 with clinical characteristics of oral cancer patients was estimated using chi-square test. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic significance of miR-101 in oral cancer.Results: Compared with healthy controls, serum miR-101 level was significantly down-regulated in oral cancer patients (P<0.001). Furthermore, low expression of miR-101 was closely associated with histological grade (P=0.037), TNM stage (P=0.018) and lymph node metastasis (P=0.023). ROC curve analysis indicated that serum miR-101 could effectively distinguish oral cancer patients from healthy controls with an area under the curve (AUC) of 0.878 (95%CI=0.834-0.922, P<0.001). The cutoff level of miR-101 expression for oral cancer diagnosis was 1.46, with the sensitivity of 82.9% and the specificity of 74.6%.Conclusions: Decreased expression of miR-101 is correlated with the aggressive progression of oral cancer. Serum miR-101 may be a promising bio-marker for early diagnosis of oral cancer.

scholarly journals Status of trace elements in saliva of oral precancer and oral cancer patients

2015 ◽  
Vol 11 (1) ◽  
pp. 146 ◽  
Author(s):  
ShishirRam Shetty ◽  
Subhas Babu ◽  
Suchetha Kumari ◽  
Pushparaja Shetty ◽  
Shruthi Hegde ◽  
...  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Oral Precancer ◽  
Oral Cancer Patients
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