scholarly journals Low High-Density Lipoprotein and Risk of Myocardial Infarction

2015 ◽  
Vol 9 ◽  
pp. CMC.S26624 ◽  
Author(s):  
A. Ramirez ◽  
P. P. Hu
Keyword(s):  
Myocardial Infarction ◽  
Clinical Trials ◽  
Independent Risk Factor ◽  
Density Lipoprotein ◽  
Structure And Function ◽  
New Agents ◽  
Low Hdl ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

Low HDL is an independent risk factor for myocardial infarction. This paper reviews our current understanding of HDL, HDL structure and function, HDL subclasses, the relationship of low HDL with myocardial infarction, HDL targeted therapy, and clinical trials and studies. Furthermore potential new agents, such as alirocumab (praluent) and evolocumab (repatha) are discussed.

scholarly journals Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function: results from Echo-SOL

Open Heart ◽  
2018 ◽  
Vol 5 (2) ◽  
pp. e000831 ◽  
Author(s):  
Melissa Suzanne Burroughs Peña ◽  
Katrina Swett ◽  
Robert C Kaplan ◽  
Krista Perreira ◽  
Martha Daviglus ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Isovolumic Relaxation Time ◽  
Shs Exposure ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Relationship Of ◽  
The Relationship ◽  
Isovolumic Relaxation

ObjectiveTo describe the relationship of household secondhand smoke (SHS) exposure and cardiac structure and function.MethodsParticipants (n=1069; 68 % female; age 45–74 years) without history of tobacco use, coronary artery disease or severe valvular disease were included. Past childhood (starting at age <13 years), adolescent/adult and current exposure to household SHS was assessed. Survey linear regression analyses were used to model the relationship of SHS exposure and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, alcohol use, physical activity and education).ResultsSHS exposure in childhood only was associated with reduced E/A velocity ratio (β=−0.06 (SE 0.02), p=0.008). SHS exposure in adolescence/adult only was associated with increased left ventricular ejection fraction (LVEF) (1.2 (0.6), p=0.04), left atrial volume index (1.7 (0.8), p=0.04) and decreased isovolumic relaxation time (−0.003 (0.002), p=0.03). SHS exposure in childhood and adolescence/adult was associated with worse left ventricular global longitudinal strain (LVGLS) (two-chamber) (0.8 (0.4), p= 0.049). Compared with individuals who do not live with a tobacco smoker, individuals who currently live with at least one tobacco smoker had reduced LVEF (−1.4 (0.6), p=0.02), LVGLS (average) (0.9 (0.40), p=0.03), medial E′ velocity (−0.5 (0.2), p=0.01), E/A ratio (−0.09 (0.03), p=0.003) and right ventricular fractional area change (−0.02 (0.01), p=0.01) with increased isovolumic relaxation time (0.006 (0.003), p=0.04).ConclusionsPast and current household exposure to SHS was associated with abnormalities in cardiac systolic and diastolic function. Reducing household SHS exposure may be an opportunity for cardiac dysfunction prevention to reduce the risk of future clinical heart failure.

The relationship of QRS morphology with cardiac structure and function in patients with heart failure

2015 ◽  
Vol 104 (11) ◽  
pp. 935-945 ◽  
Author(s):  
Pierpaolo Pellicori ◽  
Anil C. Joseph ◽  
Jufen Zhang ◽  
Elena Lukaschuk ◽  
Nasser Sherwi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Patients With Heart Failure ◽  
Qrs Morphology ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

Beautiful minds (i.e., brains) and the neural basis of intelligence

2007 ◽  
Vol 30 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Richard J. Haier ◽  
Rex E. Jung
Keyword(s):  
Cognitive Neuroscience ◽  
Brain Structure ◽  
Structure And Function ◽  
Neural Basis ◽  
Brain Structure And Function ◽  
And Function ◽  
Relationship Of ◽  
The Relationship ◽  
New Phase ◽  
Empirical Framework

AbstractThe commentaries address conceptual issues ranging from our narrow focus on neuroimaging to the various definitions of intelligence. The integration of the P-FIT and data from cognitive neuroscience is particularly important and considerable consistency is found. Overall, the commentaries affirm that advances in neuroscience techniques have caused intelligence research to enter a new phase. The P-FIT is recognized as a reasonable empirical framework to test hypotheses about the relationship of brain structure and function with intelligence and reasoning.

scholarly journals Levels of Blood Biomarkers among Patients with Myocardial Infarction in Comparison to Control Group

1970 ◽  
Vol 30 (1) ◽  
Author(s):  
Amir Shamshirian ◽  
Reza Alizadeh-Navaei ◽  
Samira Abedi ◽  
Hamed Jafarpour ◽  
Hanieh Fazli ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Laboratory Methods ◽  
Multivariable Analyses ◽  
Heart Center ◽  
Interior Walls ◽  
Relationship Of ◽  
The Relationship

BACKGROUND: Myocardial infarction (MI) as a term for a heart attack happens due to reduced blood flow to heart myocardium and lack of oxygen supply caused by plaques inthe interior walls of coronary arteries. With respect to the importance of MI etiology, we aimed to study the relationship of MI and blood examination variables.METHODS: This study was conducted in Mazandaran Heart Center as a hospital-based case-control Comprising 894 participants including 465 cases and 429 controls, individually matched by sex and age. Considered blood markers were analyzed using routine laboratory methods and equipment.RESULTS: Of all participants, 64.3% of the cases and 51.0% of the controls were males with a mean age of 61.2 (±13.8) in cases and 62.4 (±14.) in controls. We could not find any differences between cases and controls for total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and alkaline-phosphatase (ALP) (P>0.05). However, levels of creatine-kinase-muscle/brain (CK-MB) (P<0.0001), fasting-blood-sugar (FBS) (P<0.0001), aspartateaminotransferase (AST) (P<0.0001), alanine-transferase (ALT) (P<0.0001) and erythrocyte sedimentation rate (ESR) (P=0.001) were significantly higher in cases compared to the controls (P<0.05). Multivariable analyses revealed that the risk of MI was associated with high levels of AST (adjusted OR=24.3, 95%CI=3.5±165.6, P=0.001) and LDL (adjusted OR=7.4, 95%CI=1.0±51.8, P=0.001).CONCLUSION: Our investigation indicated that the levels of CK-MB, FBS, AST, ALT and ESR were significantly higher in patients with MI. Besides, our findings showed that the risk of MI in cases with high levels of AST and LDL was about 24 and 7 times more than the control group respectively.

The Relationship of Family Bonds to Family Structure and Function Across Cultures

1997 ◽  
Vol 28 (3) ◽  
pp. 303-320 ◽  
Author(s):  
James Georgas ◽  
Sophia Christakopoulou ◽  
Ype H. Poortinga ◽  
Alois Angleitner ◽  
Robin Goodwin ◽  
...  
Keyword(s):  
Family Structure ◽  
Structure And Function ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

FUNCTIONAL ZONATION OF ADRENOCORTICAL TISSUE IN THE BRUSH POSSUM (TRICHOSURUS VULPECULA)

1971 ◽  
Vol 49 (1) ◽  
pp. 131-NP ◽  
Author(s):  
G. P. VINSON ◽  
J. G. PHILLIPSt ◽  
I. CHESTER JONES ◽  
W. N. TSANG
Keyword(s):  
Adrenal Gland ◽  
Adult Female ◽  
Structure And Function ◽  
Trichosurus Vulpecula ◽  
And Function ◽  
Relationship Of ◽  
The Relationship ◽  
Special Zone

SUMMARY The relationship of structure and function in the adrenal gland of the possum Trichosurus vulpecula, has been studied using in-vitro incubation techniques. It was shown that both 17α-hydroxycorticosteroids and 17-deoxycorticosteroids were produced from radioactive pregnenolone and progesterone, and that these transformations occurred both in the definitive cortex as well as in a special zone of hypertrophied tissue found only in the adult female. In support of earlier findings, it was also shown that the adrenal cortex of the possum has a remarkable capacity to produce C19 steroids (including androstenedione and testosterone) from the radioactive precursors. While most of the transformations occurred with equal efficiency in both types of tissue, the reduction of androstenedione to testosterone seemed to take place more readily in the special hypertrophied zone of the adult female. In studies in vivo, it was found that levels of testosterone in the peripheral blood of the adult female possum were extremely high compared with man. Variations in testosterone levels were not apparently correlated with the stage of the oestrous cycle. The possible pathways by which the adrenal products are synthesized, and their physiological implications are discussed.

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