scholarly journals Levels of Blood Biomarkers among Patients with Myocardial Infarction in Comparison to Control Group

1970 ◽  
Vol 30 (1) ◽  
Author(s):  
Amir Shamshirian ◽  
Reza Alizadeh-Navaei ◽  
Samira Abedi ◽  
Hamed Jafarpour ◽  
Hanieh Fazli ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Laboratory Methods ◽  
Multivariable Analyses ◽  
Heart Center ◽  
Interior Walls ◽  
Relationship Of ◽  
The Relationship

BACKGROUND: Myocardial infarction (MI) as a term for a heart attack happens due to reduced blood flow to heart myocardium and lack of oxygen supply caused by plaques inthe interior walls of coronary arteries. With respect to the importance of MI etiology, we aimed to study the relationship of MI and blood examination variables.METHODS: This study was conducted in Mazandaran Heart Center as a hospital-based case-control Comprising 894 participants including 465 cases and 429 controls, individually matched by sex and age. Considered blood markers were analyzed using routine laboratory methods and equipment.RESULTS: Of all participants, 64.3% of the cases and 51.0% of the controls were males with a mean age of 61.2 (±13.8) in cases and 62.4 (±14.) in controls. We could not find any differences between cases and controls for total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and alkaline-phosphatase (ALP) (P>0.05). However, levels of creatine-kinase-muscle/brain (CK-MB) (P<0.0001), fasting-blood-sugar (FBS) (P<0.0001), aspartateaminotransferase (AST) (P<0.0001), alanine-transferase (ALT) (P<0.0001) and erythrocyte sedimentation rate (ESR) (P=0.001) were significantly higher in cases compared to the controls (P<0.05). Multivariable analyses revealed that the risk of MI was associated with high levels of AST (adjusted OR=24.3, 95%CI=3.5±165.6, P=0.001) and LDL (adjusted OR=7.4, 95%CI=1.0±51.8, P=0.001).CONCLUSION: Our investigation indicated that the levels of CK-MB, FBS, AST, ALT and ESR were significantly higher in patients with MI. Besides, our findings showed that the risk of MI in cases with high levels of AST and LDL was about 24 and 7 times more than the control group respectively.

P5482The lipid paradox in patients with non-ST elevation and ST elevation myocardial infarction and percutaneous coronary intervention

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C H Sia ◽  
A F W Ho ◽  
H Bulluck ◽  
H L Zheng ◽  
L L Foo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coronary Intervention ◽  
Percutaneous Coronary ◽  
Acute Mi ◽  
St Elevation ◽  
Relationship Of ◽  
The Relationship

Abstract Background/Introduction Elevated levels of low-density lipoprotein (LDL-C) and triglycerides (TG) are well-described risk factors for the development of acute myocardial infarction (MI). Despite these well-established associations, previous studies have described the existence of a “lipid paradox” in acute MI patients – Patients paradoxically have worse outcomes despite having lower LDL-C and TG levels. Purpose We conducted this study to clarify the relationship of the lipid paradox and clinical outcomes amongst non-ST elevation (NSTEMI) and ST elevation MI (STEMI) patients in patients who have had percutaneous coronary intervention. Methods We included all acute MI patients reported to the Singapore Myocardial Infarction Registry from 2007 to 2013 who have had percutaneous coronary intervention. This information was linked to the national claims database to obtain the final discharge diagnosis for re-hospitalization outcomes. Exposure of interest was the lipid profile obtained within 72 hours of the acute MI (LDL-C, TG; Total cholesterol [TC]; high-density lipoprotein [HDL-C]). Primary outcomes were all-cause mortality during hospitalization, within 30-days and within 1-year. Secondary outcomes were re-hospitalization within 1-year for heart failure, stroke and MI. Results There were 8988 NSTEMI and 12453 STEMI cases available for analysis (n=21441). The NSTEMI patients were older (60.3 years vs 57.6 years, p<0.001) and more likely to be female (15.1% vs 22.6%, p<0.001). In the NSTEMI subgroup, a lower LDL-C was paradoxically associated with better outcomes for death during hospitalization, death within 30 days from MI onset and death within 1 year from MI onset (all p<0.001) across the various LDL-C levels. Adjustment for demographic variables, co-morbidities and MI characteristics eliminated this paradox. However, in the STEMI subgroup, the lipid paradox for LDL-C persisted for all primary outcome endpoints after adjustment. In the STEMI patients, a lower HDL-C also appeared to be protective. An elevated TG level did not appear to be protective in both NSTEMI and STEMI patients after adjustment. Conclusion(s) An elevated LDL-C appears to be a protective prognostic marker in STEMI but not NSTEMI patients who have undergone percutaneous coronary intervention. This difference may be due to differing underlying pathophysiological mechanisms between the 2 populations.

scholarly journals The relationship of the serum endocan level with the CHA2DS2-VASc score in patients with paroxysmal atrial fibrillation

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Gökhan Ceyhun
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Stroke Risk ◽  
Low Density Lipoprotein ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Roc Curve Analysis ◽  
Reactive Protein ◽  
Relationship Of ◽  
The Relationship

Abstract Background In this study considering the relationship between serum endocan and CHA2DS2-VASc score, we assumed that endocan level could be a new biomarker for stroke risk in patients with paroxysmal atrial fibrillation (PAF). It was examined that endocan could be an alternative to determine the risk of stroke and anticoagulation strategy in patients with PAF. The CHA2DS2-VASc scores were calculated for 192 patients with PAF, and their serum endocan levels were measured. The patients were divided into two groups as those with low to moderate (0-1) and those with high (≥ 2) CHA2DS2-VASc scores, and the endocan levels were compared between these two groups. Results The serum endocan level was significantly higher in the high CHA2DS2-VASc score group (p < 0.001). In the multivariate logistic regression analysis, endocan, C-reactive protein, and low-density lipoprotein were found to be independent determinants of the CHA2DS2-VASc score. The predictive value of endocan was analyzed using the ROC curve analysis, which revealed that endocan predicted a high stroke risk (CHA2DS2-VASc ≥ 2) at 82.5% sensitivity and 71.2% specificity at the cutoff value of 1.342. Conclusion This study indicates that endocan is significantly associated with CHA2DS2-VASc score. We demonstrated that endocan could be a new biomarker for the prediction of a high stroke risk among patients diagnosed with PAF.

scholarly journals Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity

2019 ◽  
Author(s):  
Grzegorz Józef Nowicki ◽  
Barbara Ślusarska ◽  
Andrzej Prystupa ◽  
Maciej Polak ◽  
Maria Czubaj-Kowal ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adipose Tissue ◽  
Cardiovascular Event ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Overweight And Obesity ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Antioxidative Status ◽  
Total Antioxidative Status

Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress level. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). OxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the studied groups. Significant positive correlation between PerOx and percentage of adipose tissue (FM [%]) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with VAI in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAI of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.

Association of SLCO1B1 Polymorphisms and Atorvastatin Safety and Efficacy: A Meta-analysis

2019 ◽  
Vol 24 (34) ◽  
pp. 4044-4050 ◽  
Author(s):  
Yaming Du ◽  
Sizheng Wang ◽  
Zhangyong Chen ◽  
Shusen Sun ◽  
Zhigang Zhao ◽  
...  
Keyword(s):  
Statistical Tests ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Dominant Model ◽  
Safety And Efficacy ◽  
Atorvastatin Therapy ◽  
Relationship Of ◽  
The Relationship

Background: Atorvastatin is the best-selling statin in the market. However, some patients have to reduce drug doses or discontinue atorvastatin therapy mainly due to adverse drug reactions (ADRs). Genetic factors play an important role in the occurrence of ADRs. Aim: This study aimed to investigate the association between SLCO1B1 polymorphisms (c.521T>C or c.388A>G) and atorvastatin safety and efficacy. Methods: We systematically searched PubMed, Web of Science and Embase to screen relevant studies published before Sep 2018. This meta-analysis was performed to identify the relationship between SLCO1B1 c.521T>C or c.388A>G polymorphisms and atorvastatin-related ADRs by the odds ratios (ORs) and 95% confidence intervals (CIs). The relationship of SLCO1B1 polymorphisms and lipid-lowering effects [low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC)] was assessed in pooled data by calculating the mean difference (MD) with 95% CIs. All statistical tests were performed by the Review Manager 5.3 software. Results: A total of 13 studies involving 1,550 atorvastatin users were included in this analysis. There was a significant association between the SLCO1B1 c.521T>C polymorphism and atorvastatin-related ADRs associated with risk allele C (dominant model: OR=1.57, P=0.01). Allele C is associated with increased lipid-lowering efficacy in people with Hyperlipidemias as compared to allele T (LDL-C/dominant model: MD=6.19, P<0.00001 and (TC)/dominant model: MD=2.07, P=0.008). No association between the SLCO1B1 c.388A>G polymorphism and ADRs or efficacy was observed (P>0.05). Conclusion: SLCO1B1 c.521T>C polymorphism is a valuable biomarker for the evaluation of atorvastatin safety and efficacy.

scholarly journals Low High-Density Lipoprotein and Risk of Myocardial Infarction

2015 ◽  
Vol 9 ◽  
pp. CMC.S26624 ◽  
Author(s):  
A. Ramirez ◽  
P. P. Hu
Keyword(s):  
Myocardial Infarction ◽  
Clinical Trials ◽  
Independent Risk Factor ◽  
Density Lipoprotein ◽  
Structure And Function ◽  
New Agents ◽  
Low Hdl ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

Low HDL is an independent risk factor for myocardial infarction. This paper reviews our current understanding of HDL, HDL structure and function, HDL subclasses, the relationship of low HDL with myocardial infarction, HDL targeted therapy, and clinical trials and studies. Furthermore potential new agents, such as alirocumab (praluent) and evolocumab (repatha) are discussed.

The relationship of the epicardial fat and adipo-fibrokines in myocardial infarction

2020 ◽  
Vol 65 (9) ◽  
pp. 533-540
Author(s):  
O. V. Gruzdeva ◽  
D. A. Borodkina ◽  
Y. A. Dyleva ◽  
A. A. Kuzmina ◽  
E. V. Belik ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Epicardial Adipose Tissue ◽  
Visceral Obesity ◽  
Nonparametric Tests ◽  
Epicardial Fat ◽  
Control Group ◽  
Atrial Myocardium ◽  
Inverse Proportion ◽  
Relationship Of ◽  
The Relationship

Analysis of the relationship between the epicardial fat with adipokine and system ST2/IL-33 in-hospital period, and also with the extent of fibrosis of the atrial myocardium through the year after myocardial infarction in patients with visceral obesity. Examined 88 patients with myocardial infarction (MI). Visceral obesity (VO) is established by computed tomography. In fact the presence VO the patients divided into two groups. Determined the concentration of leptin, adiponectin, stimulating growth factor (ST-2) and interlekin-33 (IL-33) in serum on 1st, 12-day in-hospital period and 1 year after MI. Thickness epicardial adipose tissue (EAT) and the percentage of cardiovirus of the myocardium was measured by the method MRI, respectively, on the 12th day of hospitalization and a year after MI. The control group consisted of 30 people. Statistical analysis of data was performed using nonparametric tests. Patients with MI is associated with an increase in the thickness of EAT, imbalance of adipokines with increased leptin, decreased adiponectin in early in-hospital period and development of cardiovirus. Higher values of IL-33 and ЅT2 in the early in-hospital period MI patients with no accompanied by a lower prevalence of cardiovirus in the post-hospital period. The thickness of epicardial fat is directly dependent on the prevalence of myocardial fibrosis, the concentrations of IL-33 and in inverse proportion to the concentration of ЅT2. The degree of cardiovirus is in inverse proportion to the concentration of IL-33 and directly dependent on the concentration of ST2. The increase in EAT closely linked to the development of fibrosis of the atrial myocardium after year. The thickness of EAT more patients MI, which is most pronounced imbalance of adipokines. The metabolic activity of EAT correlated with increased IL-33 and ST2 decrease.

scholarly journals Influence of the polymorphism of apolipoprotein E in cerebral vascular disease

2003 ◽  
Vol 61 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Dorotéia R.S. Souza ◽  
Bernadete F. Campos ◽  
Érika F. de Arruda ◽  
Lucy J. Yamamoto ◽  
Daniel M. Trindade ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Lipid Profile ◽  
Clinical Symptoms ◽  
Statistical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Reduced Frequency ◽  
Apo E ◽  
The Relationship

The genetic heterogeneity of apolipoprotein E (apo E) has been associated with lipid profile and atherothrombotic stroke, however this association remains inconclusive. OBJECTIVE: To evaluate the relationship between the isoforms of apo E and atherothrombotic stroke, by ascertaining the frequency of its alleles and genotypes associated with the lipid profile in patients with stroke. METHOD: A total of 207 individuals were divided into two groups, consisting of 107 patients with stroke and 100 individuals without clinical symptoms of the disease. Blood samples were taken from patients and controls for molecular investigation of the apo E (epsilon2, epsilon3 and epsilon4 alleles) for the analysis of the lipid profile. RESULTS: The epsilon3 allele was the most common and its prevalence was significantly higher in patients (0.93) compared to the controls (0.86; p=0.024). The epsilon2 allele was rarely seen specifically in patients (0.02 versus 0.05 in controls, p=0.191). The epsilon4 allele was not associated with stroke showing a reduced frequency in patients (0.05) when compared to controls (0.09; p=0.011). Although higher average levels of lipid profile were found in patients when compared to controls, with statistical significance for the values of total cholesterol (TC) (203.6mg/dL±57.98 and 181.9mg/dL±68.47 respectively; p=0.003) and low-density lipoprotein cholesterol (LDLc) (131.4mg/dL±52.60 and 116mg/dL±56.38, respectively; p=0.014), these were independent of the presence of the epsilon4 allele. In control group the higher TC and LDLc values occurred in the absence of the epsilon4 allele, confirming the conflicting effect of the alleles of apo E on the plasmatic lipids and atherothrombotic stroke. CONCLUSION: The isoforms of apo E cannot be regarded as an isolated risk factor for stroke and do not show association with lipid profile in this study.

scholarly journals Comparison study of Interleukin-1 alpha between Unstable Angina and Acute Myocardial Infarction patients

2013 ◽  
Vol 10 (3) ◽  
pp. 915-920
Author(s):  
Baghdad Science Journal
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Unstable Angina ◽  
Plasma Levels ◽  
Interleukin 1 ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Significant Difference

Multiple studies support a role for inflammation in the pathogenesis of coronary atherosclerosis and unstable cardiac syndromes. However, of the known pro-inflammatory cytokines, only elevated plasma levels of interleukin-6(IL-6) have been linked to Unstable Angina. We sought to examine the plasma levels of other major proinflammatory cytokines in similar clinical settings patients with unstable angina and acute myocardial infarction and the relationship extent between them. This study aimed to investigate and compare the level of IL-1 in Unstable Angina and Acute Myocardial Infarction patients. Thirty patients with unstable angina and thirty patients with Acute Myocardial Infarction, also thirty healthy individual as control were included in this study to measure the levels of IL-1alpha, lipid profile and Body Mass Index. There was a significant increase in the level of IL-1 ? in patients with acute myocardial infarction or with unstable angina compared with control group. IL-1 ? positively correlated with total cholesterol, triglycerides, Low Density Lipoprotein and Very Low Density Lipoprotein, while there was a negative correlation with High Density Lipoprotein. In conclusionInterleukin-1 ? significantly increases in patients with acute myocardial infarction or with unstable angina. There was no significant difference in level of IL-1? between AMI and unstable angina patients.

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