scholarly journals Diets Enriched in Fish-Oil or Seal-Oil have Distinct Effects on Lipid Levels and Peroxidation in BioF1B Hamsters

2011 ◽  
Vol 4 ◽  
pp. NMI.S6728 ◽  
Author(s):  
Pratibha Dubey ◽  
Anura P. Jayasooriya ◽  
Sukhinder K. CheemaΨ
Keyword(s):  
Fish Oil ◽  
Positional Distribution ◽  
Omega 3 ◽  
Lipid Levels ◽  
High Fat ◽  
Hepatic Lipids ◽  
High Fat Diets ◽  
Seal Oil ◽  
Fat Diets ◽  
And Oxidative Stress

Aim Fish-oil omega-3 polyunsaturated fatty acids (n-3 PUFAs) are mostly esterified to the sn-2 position of triglycerides, while in seal-oil triglycerides, these are mostly esterified to the sn-1 and −3 positions. We investigated whether fish-oil and seal-oil feeding has a different effect on the regulation of lipid metabolism and oxidative stress in BioF1B hamsters. Methods BioF1B hamsters were fed high fat diets rich in fish-oil or seal-oil for 4 weeks, and fasted for 14 hours prior to blood and tissue collection. Results Plasma and hepatic lipids and lipid peroxidation levels were significantly lower in seal-oil-fed hamsters as compared to those fed fish-oil. There was a selective hindrance of clearance of lipids in fish-oil-fed hamsters as reflected by higher levels of plasma apoB48. Conclusion Differences in the fatty acid composition and positional distribution of n-3 PUFAs in triglycerides of fish-oil and seal-oil are suggested to trigger metabolic differences.

Effects of high fat diets and supplemental tart cherry and fish oil on obesity and type 2 diabetes in male and female C57BL/6J and TALLYHO/Jng mice

2021 ◽  
pp. 108644
Author(s):  
Jacaline K. Parkman ◽  
Kristiana Sklioutovskaya-Lopez ◽  
Kalhara R. Menikdiwela ◽  
Logan Freeman ◽  
Naima Moustaid-Moussa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fish Oil ◽  
Tart Cherry ◽  
High Fat ◽  
Male And Female ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice

2011 ◽  
Vol 32 (7) ◽  
pp. 1078-1084 ◽  
Author(s):  
Y.-R. Lou ◽  
Q.-Y. Peng ◽  
T. Li ◽  
C. M. Medvecky ◽  
Y. Lin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Skin Carcinogenesis ◽  
Omega 3 ◽  
High Fat ◽  
High Fat Diets ◽  
Omega 6 ◽  
Fat Diets

scholarly journals Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed ω-3 and ω-6 fatty acids

1992 ◽  
Vol 283 (2) ◽  
pp. 333-339 ◽  
Author(s):  
A C Rustan ◽  
E N Christiansen ◽  
C A Drevon
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Linseed Oil ◽  
The Other ◽  
Acid Oxidation ◽  
High Fat ◽  
High Fat Diets ◽  
Peroxisomal Fatty Acid Oxidation ◽  
Fat Diets ◽  
Peroxisomal Fatty Acid

Rats were fed, for 3 weeks, high-fat (20% w/w) diets containing sunflower-seed oil, linseed oil or fish oil. Chow-fed rats were used as a low-fat reference. The high-fat diets markedly reduced non-fasting-rat serum triacylglycerol as compared with the low-fat reference, and the highest reduction (85%) was observed with the fish-oil group, which was significantly lower than that of the other high-fat diets. The serum concentration of phospholipids was significantly reduced (30%) only in the fish-oil-fed animals, whereas serum non-esterified fatty acids were reduced 40-50% by both the fish-oil- and linseed-oil-fed groups. The liver content of triacylglycerol showed a 1.7-fold increase with the fish-oil diet and 2-2.5-fold with the other dietary groups when compared with rats fed a low-fat diet, whereas the hepatic content of phospholipids was unchanged. Peroxisomal fatty acid oxidation (acyl-CoA oxidase) was 2-fold increased for the rats fed fish oil; however this was not significantly higher when comparison was made with rats fed the linseed-oil diet. There was no difference in phosphatidate hydrolysis (microsomal and cytosolic fractions) among animals fed the various diets. Acyl-CoA:diacylglycerol acyltransferase activity was increased by all high-fat diets, but the fish-oil-diet-fed group showed a significantly lower enzyme activity than did rats fed the other high-fat diets. A linear correlation between acyl-CoA:diacylglycerol acyltransferase activity and liver triacylglycerol was observed, and the microsomal enzyme activity was decreased 40-50% by incubation in the presence of eicosapentaenoyl-CoA. CoA derivatives of arachidonic, linolenic and linoleic acid had no inhibitory effect when compared with the control. These results indicate that dietary fish oil may have greater triacylglycerol-lowering effect than other polyunsaturated diets, owing to decreased triacylglycerol synthesis caused by inhibition of acyl-CoA:diacylglycerol acyltransferase. In addition, increased peroxisomal fatty acid oxidation and decreased availability of non-esterified fatty acids could also contribute by decreasing the amounts of fatty acids as substrates for triacylglycerol synthesis and secretion.

Fish oil diet modulates epididymal and inguinal adipocyte metabolism in mice

2016 ◽  
Vol 7 (3) ◽  
pp. 1468-1476 ◽  
Author(s):  
Thereza Cristina Lonzetti Bargut ◽  
Vanessa Souza-Mello ◽  
Carlos Alberto Mandarim-de-Lacerda ◽  
Marcia Barbosa Aguila
Keyword(s):  
Adipose Tissue ◽  
Fish Oil ◽  
White Adipose Tissue ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets ◽  
Fish Oil Diet ◽  
The Impact

We aimed to investigate the impact of different high-fat diets containing fish oil on adiposity and white adipose tissue (WAT) function in mice, comparing the effects on epididymal (eWAT) and subcutaneous (sWAT) depots.

Effect of Chitosan on Hepatic Drug-Metabolizing Enzymes and Oxidative Stress in Rats Fed Low- and High-Fat Diets

2010 ◽  
Vol 58 (8) ◽  
pp. 5187-5193 ◽  
Author(s):  
Hsien-Tsung Yao ◽  
Chong-Kuei Lii ◽  
Ruey-Hwang Chou ◽  
Jia-Hsuan Lin ◽  
Hui-Ting Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drug Metabolizing Enzymes ◽  
High Fat ◽  
Metabolizing Enzymes ◽  
Hepatic Drug ◽  
High Fat Diets ◽  
Fat Diets ◽  
And Oxidative Stress

scholarly journals Biochemical hepatic alterations and body lipid composition in the herbivorous grass carp (Ctenopharyngodon idella) fed high-fat diets

2006 ◽  
Vol 95 (5) ◽  
pp. 905-915 ◽  
Author(s):  
Zhen-Yu Du ◽  
Pierre Clouet ◽  
Wen-Hui Zheng ◽  
Pascal Degrace ◽  
Li-Xia Tian ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Grass Carp ◽  
Dietary Lipid ◽  
Ctenopharyngodon Idella ◽  
Fat Tissue ◽  
Lipid Levels ◽  
High Fat ◽  
Mesenteric Fat ◽  
High Fat Diets ◽  
Fat Diets

High-fat diets may have favourable effects on growth of some carnivorous fish because of the protein-sparing effect of lipids, but high-fat diets also exert some negative impacts on flesh quality. The goal of the study was therefore to determine the effects of fat-enriched diets in juvenile grass carp (Ctenopharyngodon idella) as a typical herbivorous fish on growth and possible lipid metabolism alterations. Three isonitrogenous diets containing 2, 6 or 10% of a mixture of lard, maize oil and fish oil (1:1:1, by weight) were applied to fish for 8 weeks in a recirculation system. Data show that feeding diets with increasing lipid levels resulted in lowered feed intake, decreased growth and feed efficiency, and increased mesenteric fat tissue weight. Concomitantly, alteration of lipoprotein synthesis and greater level of lipid peroxidation were apparent in blood. In liver, muscle and mesenteric fat tissue, the percentages of α-linolenic acid and DHA were significantly increased or tended to increase with higher dietary lipid levels. Biochemical activity measurements performed on liver showed that, with the increase in dietary lipid level, there was a decrease in both mitochondrial and peroxisomal fatty acid oxidation capacities, which might contribute, at least in part, to the specific accumulation of α-linolenic acid and DHA into cells more active in membrane building. On the whole, grass carp have difficulty in energetically utilising excess dietary fat, especially when enriched in n−3 PUFA that are susceptible to peroxidation.

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