Central Corneal Melting Associated with Reformulated Generic Diclofenac in a Patient with Inferior Fornix Foreshortening

Purpose To report a case of corneal melting in a patient with fornix foreshortening being treated with reformulated generic diclofenac. Methods Case report. Results An asymptomatic 76-year old man presented with central corneal melting while being treated with reformulated generic diclofenac. This formulation did not contain the vitamin E derivative, tocophersolan, which has been felt to contribute to corneal melting associated with generic diclofenac in the past. Other factors for corneal melting included multiple medication use and altered forniceal architecture, but did not include previous corneal or cataract surgery. Following discontinuation of the topical medications and temporary tarsorrhapy, the defect reepithelialized. Conclusion In patients with a compromised ocular surface, reformulated generic diclofenac has the potential to cause corneal melting without prior cataract or refractive surgery. Use should not be indiscriminate or without close supervision.

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Profilometry. Using Corneo-scleral topography for scleral lens fitting

The Eye ◽

10.33791/2222-4408-2019-4-19-22 ◽

2019 ◽

Vol 21 (128) ◽

pp. 19-22

Author(s):

Gregory DeNaeyer

Keyword(s):

Ocular Surface ◽

World Wide ◽

Contact Lenses ◽

The Past ◽

The World ◽

The Future ◽

The Way

The world-wide use of scleral contact lenses has dramatically increased over the past 10 year and has changed the way that we manage patients with corneal irregularity. Successfully fitting them can be challenging especially for eyes that have significant asymmetries of the cornea or sclera. The future of scleral lens fitting is utilizing corneo-scleral topography to accurately measure the anterior ocular surface and then using software to design lenses that identically match the scleral surface and evenly vault the cornea. This process allows the practitioner to efficiently fit a customized scleral lens that successfully provides the patient with comfortable wear and improved vision.

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Management of Laryngeal Chondroradionecrosis with Pentoxifylline and Vitamin E – A Case Report and Review of the Literature

Oral Surgery ◽

10.1111/ors.12631 ◽

2021 ◽

Author(s):

Sanford Grossman ◽

Ricard Simo ◽

Vinod Patel

Keyword(s):

Case Report ◽

Vitamin E ◽

Review Of The Literature

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Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

International Journal of Molecular Sciences ◽

10.3390/ijms22126222 ◽

2021 ◽

Vol 22 (12) ◽

pp. 6222

Author(s):

Kacper Szewczyk ◽

Aleksandra Chojnacka ◽

Magdalena Górnicka

Keyword(s):

Vitamin E ◽

Metabolic Disorders ◽

Tissue Concentration ◽

Biological Properties ◽

Biological Role ◽

Future Research ◽

The Past ◽

The Subject ◽

The Relationship

Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research.

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Mixed Cutaneous Infection Caused byMycobacterium szulgaiandMycobacterium intermediumin a Healthy Adult Female: A Rare Case Report

Case Reports in Dermatological Medicine ◽

10.1155/2015/607519 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Amresh Kumar Singh ◽

Rungmei S. K. Marak ◽

Anand Kumar Maurya ◽

Manaswini Das ◽

Vijaya Lakshmi Nag ◽

...

Keyword(s):

Case Report ◽

Rare Case ◽

Healthy Adult ◽

Nontuberculous Mycobacteria ◽

Anterior Abdominal Wall ◽

Cutaneous Infection ◽

Once Daily ◽

The Past ◽

Rare Case Report

Nontuberculous mycobacteria (NTMs) are ubiquitous and are being increasingly reported as human opportunistic infection. Cutaneous infection caused by mixed NTM is extremely rare. We encountered the case of a 46-year-old female, who presented with multiple discharging sinuses over the lower anterior abdominal wall (over a previous appendectomy scar) for the past 2 years. Microscopy and culture of the pus discharge were done to isolate and identify the etiological agent. Finally, GenoType Mycobacterium CM/AS assay proved it to be a mixed infection caused byMycobacterium szulgaiandM. intermedium. The patient was advised a combination of rifampicin 600 mg once daily, ethambutol 600 mg once daily, and clarithromycin 500 mg twice daily to be taken along with periodic follow-up based upon clinical response as well as microbiological response. We emphasize that infections by NTM must be considered in the etiology of nonhealing wounds or sinuses, especially at postsurgical sites.

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Encounters and medication use for ocular surface disorders among patients treated with dupilumab: A cohort study

JAAD International ◽

10.1016/j.jdin.2021.03.009 ◽

2021 ◽

Vol 4 ◽

pp. 1-9

Author(s):

John S. Barbieri ◽

Vatinee Y. Bunya ◽

Mina Massaro-Giordano ◽

David J. Margolis

Keyword(s):

Cohort Study ◽

Ocular Surface ◽

Medication Use

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Ocular surface diseases and corneal refractive surgery

Current Opinion in Ophthalmology ◽

10.1097/icu.0000000000000077 ◽

2014 ◽

Vol 25 (4) ◽

pp. 264-269 ◽

Cited By ~ 16

Author(s):

Debora Garcia-Zalisnak ◽

David Nash ◽

Elizabeth Yeu

Keyword(s):

Ocular Surface ◽

Refractive Surgery ◽

Ocular Surface Diseases ◽

Corneal Refractive Surgery

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Scurvy: A Case Report

Archives of The Medicine and Case Reports ◽

10.37275/amcr.v2i1.15 ◽

2021 ◽

Vol 2 (1) ◽

pp. 78-83

Author(s):

Eka Sri Rahayu ◽

Mardy Pangarungan

Keyword(s):

Case Report ◽

Vitamin E ◽

Vitamin C ◽

Laboratory Test ◽

Computer Tomography ◽

Rare Case ◽

Behavioural Disorders ◽

Vitamin C Deficiency ◽

Great Pain ◽

Normal Laboratory

A B S T R A C TScurvy is a rare case found in many countries, but it is often found in refugeeareas, especially in Africa. Vitamin C deficiency varies based on season and occursmore in men with age. The purpose of this research is to avoid misdiagnosis so thatit can be a reference in the field of medicine to diagnose and provide management onscurvy. This prospective research was conducted with one sample of research.Observation had been carried out for two months, starting at one month after thepatient was suspected with the diagnosis of scurvy. Computer Tomography (CT) Scanlumbosacral to pelvic results were normal. Laboratory test of HB result was 9.5 g/dl,in which MCV was 63.2 fL, MCH was 20.3 pg, and MCHC was 32.1 g/dl. Scurvytreatment in the first visit was 3x1 tablets vitamin C, 3x5 ml ibuprofen Syr, andphysiotherapy. The results were that the patient still suffered swollen and bleedinggums, but the pain no longer existed, pale, behavioural disorders, unable to walk,and pain in both knees. After the second visit, the child got therapy of 4x50 mg vitaminC, 1x1 tablets vitamin B12, 1x150 IU vitamin E, 1x1 tablets cavit D3, andphysiotherapy. After two weeks of treatment, there were no complaints of swelling,painful or bleeding gums. The child could straighten her legs, but she was still unableto walk due to the trauma of feeling great pain while walking. Special attention isrequired to diagnose appropriately so the doctor can minimize and preventcomplications.

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It is not always COVID-19: Case report about an undiagnosed HIV man with dyspnea

Current HIV Research ◽

10.2174/1570162x19666210901134104 ◽

2021 ◽

Vol 19 ◽

Author(s):

Michela Pontolillo ◽

Katia Falasca ◽

Jacopo Vecchiet ◽

Claudio Ucciferri

Keyword(s):

Case Report ◽

Diagnostic Assays ◽

Radiological Features ◽

The Past ◽

Undiagnosed Hiv ◽

History Of ◽

Clinical Conditions ◽

Diagnostic Thinking ◽

Diagnostic Delays ◽

Analyze Data

Background: The current COVID-19 pandemic has attracted great attention from the medical world. In the past year, there have been reports of missed or delayed treatments for conditions that mimic COVID-19. The main symptoms caused by SARS-CoV-2, such as fever and cough, belong to different clinical conditions. It is of the utmost importance that the diagnostic thinking used to analyze data and information to reach a COVID-19 diagnosis does not overlook the plethora of different diagnoses related to these symptoms. Case report: The aim of this work is to present the clinical case of a patient having unrecognized HIV infection with a 4-week history of fever, cough, and hypoxia. When tests were allowed to highlight HIV-related immunodeficiency status, a CMV assay was performed in order to evaluate opportunistic pneumonia. Through this, diagnosis of HIV combined with CMV pneumonia was made, thus excluding COVID-19 respiratory insufficiency. Conclusion: The diagnosis of the two conditions in the COVID-19 era is challenging due to overlapping clinical and radiological features and limitations of current diagnostic assays. This causes clinical implications due to diagnostic delays.

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Asthma and Pneumomediastinum

PEDIATRICS ◽

10.1542/peds.75.5.990 ◽

1985 ◽

Vol 75 (5) ◽

pp. 990-990

Author(s):

ROBERT G. ZWERDLING

Keyword(s):

Case Report ◽

Childhood Asthma ◽

Mediastinal Emphysema ◽

Review Of The Literature ◽

Common Cause ◽

The Past ◽

Treatable Condition

To the Editor.— Sturtz's case report and brief review of the literature on spontaneous mediastinal emphysema is interesting.1 However, he neglects to mention what is perhaps the most common cause of this condition in childhood—asthma. Indeed, reports of this complication have occurred over the past 130 years.2-4 Recognition of this fact often results in an understanding of the cause for the pneumomediastinum as well as tipping the clinician off to a possibly undiagnosed but readily treatable condition.

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