Effects of chlortetracycline and Synovex-S® on growth rate and on plasma growth hormone and thyroid hormone concentrations following administration of thyrotropin-releasing hormone and GH-releasing hormone in beef steers

2007 ◽  
Vol 87 (3) ◽  
pp. 327-341
Author(s):  
S. E. Kitts ◽  
J. C. Matthews ◽  
K. K. Schillo ◽  
T. S. Rumsey ◽  
T. H. Elsasser ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Thyroid Hormones ◽  
Thyroid Stimulating Hormone ◽  
Carcass Composition ◽  
Thyrotropin Releasing Hormone ◽  
Beef Steers ◽  
Releasing Hormone ◽  
Time To Peak ◽  
Key Words Growth Hormone ◽  
Main Effects

Twenty-four Angus steers (365 kg ± 4) were assigned randomly to a 2 × 2 factorial arrangement of treatments of either 0 or 350 mg chlortetracycline d-1, with or without Synovex-S to test the effects of chlortetracycline (CTC) and estrogenic implant on release of growth hormone (GH) and thyroid hormones. Steers received ad libitum a concentrate-forage diet over a 112-d feeding study, and growth and carcass characteristics were determined. On days 30, 56, and 106, steers received an injection, via jugular catheter, of 1.0 µg kg-1 BW thyrotropin-releasing hormone (TRH) + 0.1 µg kg-1 BW GH-releasing hormone (GHRH) and blood was collected from -30 to 360 min post-injection. Overall, compared with non-implanted steers, Synovex-S increased (P ≤ 0.009) rate and efficiency of gain, decreased (P = 0.05) time to peak for GH concentrations, whereas baseline concentrations of thyroid-stimulating hormone (TSH) were increased (P = 0.03). Additionally, the TSH response curve (P ≤ 0.05) and magnitude of triiodothyronine (T3; P = 0.01) response were greater following TRH + GHRH challenge for implanted versus nonimplanted steers. There were no main effects of CTC; however, CTC attenuated (P ≤ 0.05) the effects of implant on T3 release, slaughter weight, and carcass composition. In conclusion, Synovex-S alone increased BW gain and enhanced the response of GH, TSH, and T3 to a TRH + GHRH challenge, whereas CTC alone did not affect rate and composition of gain or release of pituitary and thyroid hormones. However, CTC appeared to mitigate the effects of implant on T3 release and carcass composition. Key words: Growth hormone, thyroid, estrogen, chlortetracycline, bovine, growth

Lack of effect of thyroid hormones on the growth hormone response to thyrotropin-releasing hormone in acromegaly

Metabolism ◽  
1977 ◽  
Vol 26 (7) ◽  
pp. 801-805 ◽  
Author(s):  
Harold E. Carlson ◽  
James R. Sowers ◽  
Robert W. Rand
Keyword(s):  
Growth Hormone ◽  
Thyroid Hormones ◽  
Thyrotropin Releasing Hormone ◽  
Growth Hormone Response ◽  
Hormone Response ◽  
Releasing Hormone

Role of Thyrotropin-Releasing Hormone in Thyroid-Stimulating Hormone and Growth Hormone Regulation during Postnatal Maturation in Female Wistar Rats

Neonatology ◽  
1986 ◽  
Vol 50 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Vladimir Štrbák ◽  
Robert Angyal ◽  
Jana Jurčovičová ◽  
Anna Randušková
Keyword(s):  
Growth Hormone ◽  
Wistar Rats ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Hormone Regulation ◽  
Postnatal Maturation ◽  
Releasing Hormone ◽  
Female Wistar Rats ◽  
Stimulating Hormone

Thyroid Stimulating Hormone and Growth Hormone Responses to Thyrotropin Releasing Hormone in Anorexia Nervosa

1981 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Mark S. Gold ◽  
A. L. C. Pottash ◽  
David M. Martin ◽  
Lawrence B. Finn ◽  
Robert K. Davies
Keyword(s):  
Growth Hormone ◽  
Anorexia Nervosa ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Hormone Response ◽  
Releasing Hormone ◽  
Hormone Responses ◽  
Stimulating Hormone

Ten female patients who satisfied objective criteria for the diagnosis of anorexia nervosa were given 500 ug of thyrotropin releasing hormone. Thyroid stimulating hormone and growth hormone responses were measured in duplicate by radioimmunoassay. These patients had a low normal Δ thyroid stimulating hormone but a delayed peak response. In addition, these patients had pathological growth hormone release in response to thyrotropin releasing hormone infusion. Both delayed peak thyroid stimulating hormone and growth hormone response to thyrotropin releasing hormone have been reported for patients with hypothalamic disorders.

Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary

2004 ◽  
Vol 52 (4) ◽  
pp. 389-402 ◽  
Author(s):  
P. Van As ◽  
C. Careghi ◽  
V. Bruggeman ◽  
O. M. Onagbesan ◽  
S. Van der Geyten ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Mrna Expression ◽  
Developmental Stages ◽  
Pituitary Hormones ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Mrna Levels ◽  
Rt Pcr ◽  
Releasing Hormone ◽  
Pou Domain

Pit-1 is a pituitary-specific POU-domain DNA binding factor, which binds to and trans-activates promoters of growth hormone- (GH), prolactin- (PRL) and thyroid stimulating hormone beta- (TSHβ) encoding genes. Pit-1 has been identified in several mammalian and avian species. Thyrotropin-releasing hormone (TRH) is located in the hypothalamus and it stimulates TSH, GH and PRL release from the pituitary gland. In the present study, we successfully developed a competitive RT-PCR for the detection of Pit-1 expression in the chicken pituitary, that was sensitive enough to detect picogram levels of Pit-1 mRNA. Applying this method, the effect of TRH injections on Pit-1 mRNA expression was determined in the pituitary of chick embryos and growing chicks. In both 18-day-old embryos and 10-day-old male chicks the Pit-1 mRNA expression was significantly increased following TRH injection, thereby indicating that the stimulatory effects of TRH on several pituitary hormones is mediated via its effect on Pit-1 expression. Therefore, a semi-quantitative RT-PCR method was used to detect possible changes in GH levels. TRH affected the GH mRNA levels at both developmental stages. These results, combined with the data on Pit-1 mRNA expression, indicate that Pit-1 has a role in mediating the stimulatory effects of TRH on pituitary hormones like GH.

scholarly journals Endocrine changes and clinical profiles in depression: II. The thyrotropin-releasing hormone test

1984 ◽  
Vol 14 (4) ◽  
pp. 759-765 ◽  
Author(s):  
S. P. Calloway ◽  
R. J. Dolan ◽  
P. Fonagy ◽  
V. F. A. De Souza ◽  
A. Wakeling
Keyword(s):  
Stress Response ◽  
Thyroid Hormones ◽  
Diagnostic Category ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Thyroid Activity ◽  
Releasing Hormone ◽  
Free Thyroxine Index ◽  
Clinical Profiles

SynopsisThirty-one (43%) of 68 patients with primary depression were found to have a blunted thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH). Increased thyroid activity, as measured by the free thyroxine index (FTI), was present in 16 (24%) of the patients. Patients with blunted responses had a higher mean FTI level than those with normal responses. Patients with blunted responses were significantly more likely to exhibit the symptoms of depersonalization, derealization and agitation. There was no clear association between blunting and any particular diagnostic category of depression.Patients with blunted responses and high FTI values were more likely to report significant long-term environmental difficulties than patients with blunted responses and normal FTI values. It is suggested that there may be more than one mechanism responsible for blunting of the TSH response in depressed patients. In some patients blunting may be due to negative feedback from increased output of thyroid hormones, possibly released as part of a stress response. In other patients blunting may be due to a different mechanism, possibly involving pituitary gland dysfunction. These mechanisms would not necessarily be mutually exclusive in any one patient.

Thyrotropin-Releasing Hormone Stimulates Body Weight Gain and Increases Thyroid Hormones and Growth Hormone in Plasma of Cockerels

Endocrinology ◽  
1984 ◽  
Vol 115 (2) ◽  
pp. 736-740 ◽  
Author(s):  
F. C. LEUNG ◽  
J. E. TAYLOR ◽  
A. VAN IDERSTINE
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Weight Gain ◽  
Thyroid Hormones ◽  
Body Weight Gain ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone

scholarly journals Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones

2010 ◽  
Vol 95 (3) ◽  
pp. 1474-1474
Author(s):  
Enikő Bodó ◽  
Benedikt Kany ◽  
Erzsébet Gáspár ◽  
Jana Knüver ◽  
Arno Kromminga ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Stimulating Hormone

Abnormal thyroid stimulating hormone, prolactin, and growth hormone responses to thyrotropin releasing hormone in abstinent alcoholic men with cerebral atrophy

1989 ◽  
Vol 28 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Carlo Marchesi ◽  
Tito Campanini ◽  
Annamaria Govi ◽  
Eugenio Tampieri ◽  
Angelo Gnudi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cerebral Atrophy ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Responses ◽  
Stimulating Hormone
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