METABOLISM OF ALIPHATIC NITRO COMPOUNDS IN BOVINE RUMEN FLUID

1980 ◽  
Vol 60 (2) ◽  
pp. 319-325 ◽  
Author(s):  
W. MAJAK ◽  
L. J. CLARK
Keyword(s):  
Nitro Compound ◽  
Clearance Rate ◽  
Rumen Fluid ◽  
Nitro Compounds ◽  
Aliphatic Nitro Compounds ◽  
Bovine Rumen ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Metabolic studies with rumen fluid were conducted to determine rates of disappearance for 3-nitropropanol (3NPOH) and 3-nitropropionic acid (NPA), forage constituents which can be toxic to ruminants and non-ruminants. The in vitro rate of disappearance for NPA was substantially greater (P < 0.01) than for 3NPOH. The nitro compounds were metabolized most effectively when the inoculum originated from cattle fed orchardgrass soilage as compared with orchardgrass hay, alfalfa soilage or alfalfa hay. The in vivo ruminai clearance rate was substantially greater (P < 0.05) for 3NPHO than for 2-nitropropanol, a nitro compound which was not metabolized in vitro and this would be predicted if metabolism in the rumen contributed to the rate of 3NPOH disappearance.

Toxicological investigations on Astragalus hamosus and Astragalus sesameus

1980 ◽  
Vol 20 (103) ◽  
pp. 162 ◽  
Author(s):  
MC Williams
Keyword(s):  
Nitro Compounds ◽  
Aliphatic Nitro Compounds ◽  
Water Extracts ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Astragalus hamosus L. and Astragalus sesameus L. were examined for the presence and type of aliphatic nitro compounds and for their toxicity to 1 -week-old chicks. A. hamosus leaves assayed 10 to 11 mg of NO2 g-1 in compounds that yielded 3-nitropropionic acid upon hydrolysis. Water extracts of A. hamosus leaves were toxic to chicks at the equivalent of 3 g of dried plant per chick, and lethal at 6 to 8 g. A. sesameus did not contain nitro compounds and was non-toxic to chicks.

scholarly journals Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo

2001 ◽  
Vol 132 (3) ◽  
pp. 693-702 ◽  
Author(s):  
David Pubill ◽  
Ester Verdaguer ◽  
Anna Ma Canudas ◽  
Francesc Xavier Sureda ◽  
Elena Escubedo ◽  
...  
Keyword(s):  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

scholarly journals Protective Effects of Aqueous Extract ofLuehea divaricataagainst Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Aline Alves Courtes ◽  
Letícia Priscila Arantes ◽  
Rômulo Pillon Barcelos ◽  
Ingrid Kich da Silva ◽  
Aline Augusti Boligon ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Antioxidant Properties ◽  
Male Rats ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease. Accordingly, 3-nitropropionic acid (3-NP) has been found to effectively produce HD-like symptoms.Luehea divaricata(L. divaricata), popularly known in Brazil as “açoita-cavalo,” may act as a neuroprotective agentin vitroandin vivo. We evaluated the hypothesis that the aqueous extract ofL. divaricatacould prevent behavioral and oxidative alterations induced by 3-NP in rats. 25 adult Wistar male rats were divided into 5 groups: (1) control, (2)L. divaricata(1000 mg/kg), (3) 3-NP, (4)L. divaricata(500 mg/kg) + 3-NP, and (5)L. divaricata(1000 mg/kg) + 3-NP. Groups 2, 4, and 5 receivedL. divaricatavia intragastric gavage daily for 10 days. Animals in groups 3, 4, and 5 received 20 mg/kg 3-NP daily from days 8–10. At day 10, parameters of locomotor activity and biochemical evaluations were performed. Indeed, rats treated with 3-NP showed decreased locomotor activity compared to controls. Additionally, 3-NP increased levels of reactive oxygen species and lipid peroxidation and decreased ratio of GSH/GSSG and acetylcholinesterase activity in cortex and/or striatum. Our results suggest that rats pretreated withL. divaricataprior to 3-NP treatment showed neuroprotective effects when compared to 3-NP treated controls, which may be due to its antioxidant properties.

Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies

2003 ◽  
Vol 12 (2) ◽  
pp. 121-132 ◽  
Author(s):  
Jae K Ryu ◽  
Atsushi Nagai ◽  
Jean Kim ◽  
Min C Lee ◽  
James G McLarnon ◽  
...  
Keyword(s):  
Cell Death ◽  
Microglial Activation ◽  
In Vivo Studies ◽  
Nitropropionic Acid ◽  
Mitochondrial Toxin ◽  
3 Nitropropionic Acid

Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity

2000 ◽  
Vol 425 (4) ◽  
pp. 471-478 ◽  
Author(s):  
Liza Leventhal ◽  
Caryl E. Sortwell ◽  
Rose Hanbury ◽  
Timothy J. Collier ◽  
Jeffrey H. Kordower ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Striatal Neurons ◽  
Nitropropionic Acid ◽  
Acid Toxicity ◽  
3 Nitropropionic Acid
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