Increased Risk of Osteoporosis in Gastric Cancer Survivors Compared to General Population Control: A Study with Representative Korean Population

Introduction: The incidence and prognostic impact of subsequent primary gastric cancer (GC) in a population of other cancer survivors is unclear. We aimed to evaluate susceptibility to subsequent primary GC in cancer survivors and prognosis of GC with prior cancer history. Methods: 2,211 and 23,416 GC cases with and without prior cancer history were retrospectively selected from the Surveillance, Epidemiology and End Results (SEER) database. Potential risk of developing subsequent primary GC was assessed through standardized incidence ratios (SIRs). Cox regression were adopted to analyze the influence of prior cancer history and clinical characteristic factors on the prognosis of subsequent primary GC. A nomogram was established to predict overall survival (OS). Propensity score matching (PSM) was conducted to eliminate possible bias. Results: Compared with general population, cancer survivors had an increased risk of subsequent primary GC (SIR 1.17, 95% CI 1.15-1.20, P<0.05). Prior cancer history was related to poor OS of GC [adjusted hazard ratio (aHR) 1.12, 95% CI 1.06-1.19, P<0.001], but not cancer-specific survival (aHR 0.97, 95% CI 0.89-1.05, P=0.441). In addition, age, grade, stage, year of diagnosis, surgery, TNM stage and tumor size were independent prognostic factors for OS in GC cases with prior cancers. The concordance index of the nomogram was 0.72 (95% CI 0.71-0.74), and calibrate curves showed good agreement between prediction by the nomogram and actual observation. Conclusions: Cancer survivors with increased risk of developing subsequent primary GC should strengthen their monitoring and follow-up to prevent occurrence of subsequent primary gastric cancer.

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Comparison of Diabetes Management Status between Cancer Survivors and the General Population: Results from a Korean Population-Based Survey

PLoS ONE ◽

10.1371/journal.pone.0110412 ◽

2014 ◽

Vol 9 (10) ◽

pp. e110412 ◽

Cited By ~ 8

Author(s):

Ji-Yeon Shin ◽

Hye Young Shim ◽

Jae Kwan Jun

Keyword(s):

General Population ◽

Cancer Survivors ◽

Diabetes Management ◽

Population Based ◽

Korean Population ◽

Population Based Survey

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Protection offered by COVID-19 vaccines in reducing SARS-CoV-2 infection frequency; severity and mortality, among Indian Healthcare Workers: Multicenter, pan-Fortis study

10.21203/rs.3.rs-1055978/v1 ◽

2021 ◽

Author(s):

Subrat Acharya ◽

Gaurav Mahindra ◽

Purushottam Nirala ◽

Sulabh Tripathi ◽

Bishnu Panigrahi ◽

...

Keyword(s):

General Population ◽

Healthcare Workers ◽

Case Fatality Rate ◽

Population Control ◽

Real Life ◽

Case Fatality ◽

Infection Frequency ◽

Fatality Rate ◽

Indian States ◽

Increased Risk

Abstract During COVID-19 pandemic, Healthcare Workers (HCWs) were at increased risk for exposure to SARS-CoV-2 virus and prioritized for early administration of COVID-19 vaccines in India. Real-life scenario information among vaccinated HCWs acquiring COVID-19 infection, is scarce. We retrospectively analyzed COVID-19 infection frequency, severity, and associated mortality among healthcare workers, immunized with either Covishield or Covaxin vaccines at 27 Fortis Hospitals across 11 Indian states. Positive cases were identified based on RT-PCR or rapid antigen tests for SARS-CoV-2 between 16th January 2021 till 15th May 2021. 20034 HCWs received vaccination. 3971 received 1 dose, 16063 received 2 doses. Post-vaccination, 1139 HCWs acquired COVID-19 infection, 180 (4.53%) and 959 (5.97%) among partially and fully vaccinated category, respectively. Breakthrough infection occurred among 913 (5.68%) HCWs. Concurrently, Case Positivity Rate was 11.9%, among general population (control). Among 1139 positive cases, mild, moderate, and severe infections were 1059 (93%), 71 (6.2%) and 9 (0.8%), respectively with Case Fatality Rate of 0.18%, compared to 0.92% among general population (p=0.0043). The Case Fatality Rate in vaccinated HCWs was found to be 80% less than that in general population (control). Hence, COVID-19 vaccines available in India seem to be effective against SARS-CoV-2 virus.

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Protection offered by COVID-19 vaccines in reducing SARS-CoV-2 infection frequency; severity and mortality, among Indian Healthcare Workers: Multicenter, pan-Fortis study

10.21203/rs.3.rs-1056314/v1 ◽

2021 ◽

Author(s):

Subrat Acharya ◽

Gaurav Mahindra

Keyword(s):

General Population ◽

Healthcare Workers ◽

Case Fatality Rate ◽

Population Control ◽

Real Life ◽

Case Fatality ◽

Infection Frequency ◽

Fatality Rate ◽

Indian States ◽

Increased Risk

Abstract During COVID-19 pandemic, Healthcare Workers (HCWs) were at increased risk for exposure to SARS-CoV-2 virus and prioritized for early administration of COVID-19 vaccines in India. Real-life scenario information among vaccinated HCWs acquiring COVID-19 infection, is scarce. We retrospectively analyzed COVID-19 infection frequency, severity, and associated mortality among healthcare workers, immunized with either Covishield or Covaxin vaccines at 27 Fortis Hospitals across 11 Indian states. Positive cases were identified based on RT-PCR or rapid antigen tests for SARS-CoV-2 between 16th January 2021 till 15th May 2021. 20034 HCWs received vaccination. 3971 received 1 dose, 16063 received 2 doses. Post-vaccination, 1139 HCWs acquired COVID-19 infection, 180 (4.53%) and 959 (5.97%) among partially and fully vaccinated category, respectively. Breakthrough infection occurred among 913 (5.68%) HCWs. Concurrently, Case Positivity Rate was 11.9%, among general population (control). Among 1139 positive cases, mild, moderate, and severe infections were 1059 (93%), 71 (6.2%) and 9 (0.8%), respectively with Case Fatality Rate of 0.18%, compared to 0.92% among general population (p=0.0043). The Case Fatality Rate in vaccinated HCWs was found to be 80% less than that in general population (control). Hence, COVID-19 vaccines available in India seem to be effective against SARS-CoV-2 virus.

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Increased Risk of Gastric Cancer in Asbestos-Exposed Workers: A Retrospective Cohort Study Based on Taiwan Cancer Registry 1980–2015

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18147521 ◽

2021 ◽

Vol 18 (14) ◽

pp. 7521

Author(s):

Yi-Jen Fang ◽

Hung-Yi Chuang ◽

Chih-Hong Pan ◽

Yu-Yin Chang ◽

Yawen Cheng ◽

...

Keyword(s):

Gastric Cancer ◽

Cohort Study ◽

General Population ◽

Cancer Registry ◽

Malignant Mesothelioma ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Increased Risk ◽

Exposed Workers ◽

Occupational Cohort

Asbestos has been recognized as a human carcinogen associated with malignant mesothelioma, cancers of lung, larynx, and ovary. However, a putative association between gastric cancer and asbestos exposure remains controversial. In this study, we aimed to explore gastric cancer risk of workers potentially exposed to asbestos in Taiwan. The asbestos occupational cohort was established from 1950 to 2015 based on the Taiwan Labor Insurance Database, and Taiwan Environmental Protection Agency regulatory datasets, followed by the Taiwan Cancer Registry for the period 1980–2015. Standardized incidence ratios (SIRs) for cancer were computed for the whole cohort using reference rates of the general population, and also reference labor population. Compared with the general population, SIR of the asbestos occupational cohort for the gastric cancer increased both in males (1.05, 95% confidence interval (CI): 1.02–1.09) and females (1.10, 95% CI: 1.01–1.18). A total of 123 worksites were identified to have cases of malignant mesothelioma, where increased risk for gastric cancer was found with a relative risk of 1.76 (95% CI: 1.63–1.90). This 35-year retrospective cohort study of asbestos-exposed workers in Taiwan may provide support for an association between occupational exposure to asbestos and gastric cancer.

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Investigation of INDEL variants in apoptosis: the relevance to gastric cancer

BMC Medical Genetics ◽

10.1186/s12881-020-01138-3 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Giovanna Chaves Cavalcante ◽

Milene Raiol de Moraes ◽

Cristina Maria Duarte Valente ◽

Caio Santos Silva ◽

Antônio André Conde Modesto ◽

...

Keyword(s):

Gastric Cancer ◽

Cell Death ◽

General Population ◽

Multiplex Pcr ◽

Population Control ◽

Gastric Carcinogenesis ◽

Amazon Region ◽

Indel Markers

Abstract Background Apoptosis is a type of cell death involved in different pathways inherent to the cell and the evasion from this mechanism has been related to cancer, although this process remains not very well comprehended. Gastric cancer (GC) is one of the most incident and aggressive types of cancer worldwide. In this study, we analyzed the distribution of INDEL variants in GC patients (Case) and individuals from the general population (Control) from the Amazon region, in which GC is remarkably frequent. Methods A panel of nine INDEL markers in apoptosis-related genes (BCL2 rs11269260, CASP3 rs4647655, CASP8 rs3834129 and rs59308963, CASP9 rs4645982 and rs61079693, FADD rs4197, FAS rs10562972 and TP53 rs17880560) was developed and genotyped by multiplex PCR in both groups. Results In our analyses, only marker rs4197 (FADD gene) was associated to GC development as follows: INS/DEL genotype of rs4197 increasing in about 2-fold the chances of developing this type of cancer (P = 0.046; OR = 1.940; 95%CI = 1.011–3.725). Conclusion Our results suggest that rs4197 (FADD gene) might play a role in gastric carcinogenesis in the investigated population. More studies are needed to clarify this relation. Here, we highlight the importance of investigating INDEL variants in genes involved in apoptosis.

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The risk of malignancy in patients with IgG4-related disease: a systematic review and meta-analysis

Arthritis Research & Therapy ◽

10.1186/s13075-021-02652-2 ◽

2022 ◽

Vol 24 (1) ◽

Author(s):

Tingfeng Yu ◽

Yaxian Wu ◽

Jia Liu ◽

Yanyan Zhuang ◽

Xiaoyan Jin ◽

...

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

General Population ◽

Publication Bias ◽

Meta Analysis ◽

Related Disease ◽

Igg4 Related Disease ◽

Increased Risk ◽

Risk Of Malignancy ◽

Risk Of Cancer

Abstract Background The relationship between IgG4-related disease (IgG4-RD) and the risk of malignancy is still controversial. This article focused on assessing the risk of cancer in patients with IgG4-RD by meta-analysis. Methods We conducted a systematic review of the literature and meta-analysis characterizing the associated risk of overall malignancy and four site-specific malignancies (pancreas, lung, gastric and lymphoma) in patients with IgG4-RD. A search from 2003 to 2020 was performed using specified terms from PubMed, Embase, Web of Science and SinoMed. Random-effects model analysis was used to pool standardized incidence ratios (SIRs) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses were conducted to clarify the heterogeneity of the included studies. Begg’s funnel plot and Egger’s linear regression test were used to evaluate the bias of the meta-analysis. A P value < 0.05 indicated the existence of publication bias. Results A total of 10 studies were included in the article. The overall SIR estimates suggested an increased risk of overall cancer in IgG4-RD patients (SIR 2.57 95% CI 1.72–3.84) compared with the general population. The specific SIRs for pancreas and lymphoma were higher than those of the general population in IgG4-RD patients (SIR 4.07 95% CI 1.04–15.92, SIR 69.17 95% CI 3.91–1223.04, respectively). No significant associations were revealed in respiratory and gastric cancer (SIR 2.14 95% CI 0.97–4.75, SIR 0.95 95% CI 0.24–3.95, respectively). Four studies were found to be the major sources of heterogeneity by sensitivity analysis. There was no evidence of publication bias via Egger’s test. Conclusion Compared with the general population, patients with IgG4-RD appear to have a higher risk of overall cancer, especially pancreatic and lymphoma. The risk of lung and gastric cancer was not different between IgG4-RD patients and the general population.

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Increased Risk of Osteoporotic Fracture in Postgastrectomy Gastric Cancer Survivors Compared With Matched Controls

The American Journal of Gastroenterology ◽

10.14309/ajg.0000000000000436 ◽

2019 ◽

Vol 114 (11) ◽

pp. 1735-1743 ◽

Cited By ~ 2

Author(s):

Dong Wook Shin ◽

Beomseok Suh ◽

Hyunsun Lim ◽

Yun-Suhk Suh ◽

Yoon Jin Choi ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Survivors ◽

Osteoporotic Fracture ◽

Increased Risk

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Increased Risk of Suicide among Cancer Survivors Who Developed a Second Malignant Neoplasm

Computational Intelligence and Neuroscience ◽

10.1155/2022/2066133 ◽

2022 ◽

Vol 2022 ◽

pp. 1-11

Author(s):

Huazhen Yang ◽

Yuanyuan Qu ◽

Yanan Shang ◽

Chengshi Wang ◽

Junren Wang ◽

...

Keyword(s):

General Population ◽

Cancer Survivors ◽

Cancer Diagnosis ◽

Malignant Neoplasm ◽

Sociodemographic Factors ◽

Population Based ◽

Second Malignant Neoplasm ◽

Suicide Death ◽

Increased Risk ◽

Standardized Mortality Ratios

Background. Cancer diagnosis entails substantial psychological distress and is associated with dramatically increased risks of suicidal behaviors. However, little is known about the suicide risk among cancer survivors who developed a second malignant neoplasm (SMN). Methods. Using the Surveillance, Epidemiology, and End Results database, we conducted a population-based cohort study involving 7,824,709 patients with first malignant neoplasm (FMN). We measured the hazard ratios (HRs) of suicide death after receiving a SMN diagnosis using Cox proportional hazard models, as compared with patients with FMN. The comparison with the US population was achieved by calculating standardized mortality ratios (SMRs). Results. Totally 685,727 FMN patients received a diagnosis of SMN during follow-up, and we in total identified 10,930 and 937 suicide deaths among FMN and SMN patients, respectively. The HR of suicide deaths was 1.23 (95% confidence interval (CI), 1.14–1.31) after a SMN diagnosis, compared with FMN patients, after adjusting for sociodemographic factors, tumor characteristics, and cancer treatment. As compared with the general population, while both SMN and FMN patients suffered an increased risk of suicide deaths, the excess risk was higher among SMN patients than FMN patients (age-, sex-, and calendar-year-adjusted SMR 1.65 (95% CI 1.54–1.75) vs. 1.29 (95% CI 1.26–1.31); P difference < 0.0001 ). Notably, across different time periods, we observed the greatest risk elevation during the first 3 months after a cancer diagnosis. Conclusions. Compared with either patients with FMN or the general population, cancer survivors who received a SMN diagnosis were at increased risk of suicide death. The risk elevation was most prominent soon after the cancer diagnosis, highlighting the necessity of providing timely psychological support to cancer survivors with a SMN.

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