scholarly journals RNA interference targeting of A1 receptor-overexpressing breast carcinoma cells leads to diminished rates of cell proliferation and induction of apoptosis

2005 ◽  
Vol 4 (12) ◽  
pp. 1355-1360 ◽  
Author(s):  
Asra Mirza ◽  
Andrea Basso ◽  
Stuart Black ◽  
Michael Malkowski ◽  
Lia Kwee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Rna Interference ◽  
Breast Carcinoma ◽  
Carcinoma Cells ◽  
Breast Carcinoma Cells ◽  
A1 Receptor ◽  
Induction Of Apoptosis

scholarly journals Collagen and Discoidin Domain Receptor 1 Partnership: A Multifaceted Role in the Regulation of Breast Carcinoma Cell Phenotype

2021 ◽  
Vol 9 ◽  
Author(s):  
Charles Saby ◽  
Erik Maquoi ◽  
Frédéric Saltel ◽  
Hamid Morjani
Keyword(s):  
Cell Proliferation ◽  
Breast Carcinoma ◽  
Type I Collagen ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Type I ◽  
Collagen Remodeling ◽  
Breast Carcinoma Cells ◽  
Discoidin Domain Receptor ◽  
Discoidin Domain Receptor 1

Type I collagen, the major components of breast interstitial stroma, is able to regulate breast carcinoma cell behavior. Discoidin domain receptor 1 (DDR1) is a type I collagen receptor playing a key role in this process. In fact, collagen/DDR1 axis is able to trigger the downregulation of cell proliferation and the activation of BIK-mediated apoptosis pathway. The aim of this review is to discuss the role of two important factors that regulate these processes. The first factor is the level of DDR1 expression. DDR1 is highly expressed in epithelial-like breast carcinoma cells, but poorly in basal-like ones. Moreover, DDR1 undergoes cleavage by MT1-MMP, which is highly expressed in basal-like breast carcinoma cells. The second factor is type I collagen remodeling since DDR1 activation depends on its fibrillar organization. Collagen remodeling is involved in the regulation of cell proliferation and apoptosis through age- and proteolysis-related modifications.

KV1.1 K+ Channels Identification in Human Breast Carcinoma Cells: Involvement in Cell Proliferation

2000 ◽  
Vol 278 (2) ◽  
pp. 272-277 ◽  
Author(s):  
H. Ouadid-Ahidouch ◽  
F. Chaussade ◽  
M. Roudbaraki ◽  
C. Slomianny ◽  
E. Dewailly ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Breast Carcinoma ◽  
Carcinoma Cells ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
K Channels ◽  
Breast Carcinoma Cells ◽  
Human Breast Carcinoma Cells

scholarly journals Overexpression of neogenin inhibits cell proliferation and induces apoptosis in human MDA-MB-231 breast carcinoma cells

2015 ◽  
Vol 34 (1) ◽  
pp. 258-264 ◽  
Author(s):  
QINGSONG ZHANG ◽  
FANG LIANG ◽  
YANG KE ◽  
YANPING HUO ◽  
MINGCHUANG LI ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Breast Carcinoma ◽  
Carcinoma Cells ◽  
Breast Carcinoma Cells
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