scholarly journals The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer

2007 ◽  
Vol 6 (6) ◽  
pp. 905-911 ◽  
Author(s):  
Mayumi Iwakawa ◽  
Tatsuya Ohno ◽  
Kaori Imadome ◽  
Miyako Nakawatari ◽  
Ken-Ichi Ishikawa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Death ◽  
Signaling Pathway ◽  
Biopsy Specimens ◽  
Concurrent Use ◽  
Radiation Induced ◽  
Cell Death Signaling

scholarly journals Chloroplasts of Arabidopsis Are the Source and a Primary Target of a Plant-Specific Programmed Cell Death Signaling Pathway

2012 ◽  
Vol 24 (7) ◽  
pp. 3026-3039 ◽  
Author(s):  
Chanhong Kim ◽  
Rasa Meskauskiene ◽  
Shengrui Zhang ◽  
Keun Pyo Lee ◽  
Munusamy Lakshmanan Ashok ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Signaling Pathway ◽  
Primary Target ◽  
Cell Death Signaling

C-Myc regulates radiation-induced G2/M cell cycle arrest and cell death in human cervical cancer cells

2017 ◽  
Vol 43 (4) ◽  
pp. 729-735 ◽  
Author(s):  
Fengmei Cui ◽  
Jun Hou ◽  
Chengcheng Huang ◽  
Xiujin Sun ◽  
Yanan Zeng ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cervical Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
M Cell ◽  
Cycle Arrest ◽  
Cervical Cancer Cells ◽  
Radiation Induced ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

scholarly journals SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Songyan Wang ◽  
Cliff J. Luke ◽  
Stephen C. Pak ◽  
Victoria Shi ◽  
Liyun Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Death ◽  
Protease Inhibitor ◽  
Cancer Cells ◽  
Cathepsin L ◽  
Cysteine Protease Inhibitor ◽  
Knock Out ◽  
Lysosomal Protease ◽  
Cervical Cancer Cells ◽  
Radiation Induced

AbstractThe endogenous lysosomal cysteine protease inhibitor SERPINB3 (squamous cell carcinoma antigen 1, SCCA1) is elevated in patients with cervical cancer and other malignancies. High serum SERPINB3 is prognostic for recurrence and death following chemoradiation therapy. Cervical cancer cells genetically lacking SERPINB3 are more sensitive to ionizing radiation (IR), suggesting this protease inhibitor plays a role in therapeutic response. Here we demonstrate that SERPINB3-deficient cells have enhanced sensitivity to IR-induced cell death. Knock out of SERPINB3 sensitizes cells to a greater extent than cisplatin, the current standard of care. IR in SERPINB3 deficient cervical carcinoma cells induces predominantly necrotic cell death, with biochemical and cellular features of lysoptosis. Rescue with wild-type SERPINB3 or a reactive site loop mutant indicates that protease inhibitory activity is required to protect cervical tumor cells from radiation-induced death. Transcriptomics analysis of primary cervix tumor samples and genetic knock out demonstrates a role for the lysosomal protease cathepsin L in radiation-induced cell death in SERPINB3 knock-out cells. These data support targeting of SERPINB3 and lysoptosis to treat radioresistant cervical cancers.

The roles of mitochondria in radiation-induced autophagic cell death in cervical cancer cells

Tumor Biology ◽  
2015 ◽  
Vol 37 (3) ◽  
pp. 4083-4091 ◽  
Author(s):  
Zongyan Chen ◽  
Benli Wang ◽  
Feifei Yu ◽  
Qiao Chen ◽  
Yuxi Tian ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Autophagic Cell Death ◽  
Cervical Cancer Cells ◽  
Radiation Induced

Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex

BioMetals ◽  
2014 ◽  
Vol 27 (3) ◽  
pp. 445-458 ◽  
Author(s):  
Jieyuan Wu ◽  
Wei Chen ◽  
Yan Yin ◽  
Zhongliang Zheng ◽  
Guolin Zou
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Signaling Pathway ◽  
Hepg2 Cell ◽  
Hepg2 Cell Line ◽  
Phenanthroline Complex ◽  
Cell Death Signaling
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