Disease risk screening using plasma free amino acids: Initial commercialization and future potential

2018 ◽  
Vol 08 ◽  
Author(s):  
Takeshi Kimura
Keyword(s):  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Disease Risk ◽  
Risk Screening ◽  
Future Potential ◽  
Plasma Free Amino Acids

The Level of Plasma Free Amino Acids in Children with Acute Diseases (Part I)

1974 ◽  
Vol 16 (1) ◽  
pp. 54-54
Author(s):  
Teruo Honda ◽  
Naoya Morishima ◽  
Tetsuhiko Matsuno ◽  
Toshihiko Sasaki
Keyword(s):  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Plasma Free Amino Acids

scholarly journals Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
MH Mahbub ◽  
Natsu Yamaguchi ◽  
Hidekazu Takahashi ◽  
Ryosuke Hase ◽  
Yasutaka Ishimaru ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Plasma Free Amino Acids

Plasma free amino acids in the chronically uremic rat

1975 ◽  
Vol 8 (1-6) ◽  
pp. 303-306 ◽  
Author(s):  
A. Mannan ◽  
L.I. Wiebe ◽  
A.A. Noujaim ◽  
D.C. Secord
Keyword(s):  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Plasma Free Amino Acids

Effect of Iodoacetate Addition to Blood on the Concentration of Plasma Free Amino Acids

1968 ◽  
Vol 128 (3) ◽  
pp. 731-733 ◽  
Author(s):  
W. D. Block ◽  
M. E. Markovs ◽  
B. F. Steele
Keyword(s):  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Plasma Free Amino Acids

Early alterations of plasma free amino acids in chronic renal failure

1990 ◽  
Vol 188 (2) ◽  
pp. 101-108 ◽  
Author(s):  
I. Ceballos ◽  
P. Chauveau ◽  
V. Guerin ◽  
J. Bardet ◽  
P. Parvy ◽  
...  
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Free Amino Acids ◽  
Free Amino ◽  
Plasma Free Amino Acids

Plasma Free Amino Acids of Children Consuming as Diet with Uneven Distribution of Protein Relative to Energy

1976 ◽  
Vol 106 (2) ◽  
pp. 241-248 ◽  
Author(s):  
William C. Maclean ◽  
Robert P. Placko ◽  
George G. Graham
Keyword(s):  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Uneven Distribution ◽  
Plasma Free Amino Acids

P3-260: ALTERATION OF PLASMA-FREE AMINO ACIDS (PFAAS) AND AMINES COULD BE NOVEL BLOOD-BASED BIOMARKERS FOR DETECTION OF ALZHEIMER'S DISEASE AND FUTURE PROGRESSION

2006 ◽  
Vol 14 (7S_Part_22) ◽  
pp. P1174-P1174
Author(s):  
Yuki Yano ◽  
Nobuhiro Kawai ◽  
Takahiko Muramatsu ◽  
Naoko Arashida ◽  
Rumi Nishimoto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Plasma Free Amino Acids

scholarly journals Use of plasma-free amino acids as biomarkers for detecting and predicting disease risk

2020 ◽  
Vol 78 (Supplement_3) ◽  
pp. 79-85
Author(s):  
Kenji Nagao ◽  
Takeshi Kimura
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Free Amino ◽  
Disease Risk ◽  
The Elderly ◽  
Essential Amino Acids ◽  
Clinical Findings ◽  
Amino Acid Supplementation ◽  
Diabetes Prediction ◽  
Plasma Free Amino Acids

Abstract This paper reviews developments regarding the use of plasma-free amino acid (PFAA) profiles as biomarkers for detecting and predicting disease risk. This work was initiated and first published in 2006 and was subsequently developed by Ajinomoto Co., Inc. After commercialization in 2011, PFAA-based tests were adopted in over 1500 clinics and hospitals in Japan, and numerous clinician-led studies have been performed to validate these tests. Evidence is accumulating that PFAA profiles can be used for diabetes prediction and evaluation of frailty; in particular, decreased plasma essential amino acids could contribute to the pathophysiology of severe frailty. Integration of PFAA evaluation as a biomarker and effective essential amino acid supplementation, which improves physical and mental functions in the elderly, could facilitate the development of precision nutrition, including personalized solutions. This present review provides the background for the technology as well as more recent clinical findings, and offers future possibilities regarding the implementation of precision nutrition.

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