Evaluation of Diuretic Activity of Hydro-Ethanolic Extract of Moringa Stenopetala Leaves in Swiss Albino Mice

INTRODUCTION: Pain has been described by the International Association for the Study of Pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Although NSAIDS and OPIOIDS are available for the treatment, still pain (chronic) is major problem. The present study was designed to study the analgesic effect of ethanolic extract of Coriandrum sativum using hot plate method and acetic acid induced writhing method in experimental animals (Swiss albino mice). MATERIAL AND METHODS:The analgesic effect of leaves and seeds of Coriandrum sativum was assessed using hot plate method and acetic acid induced writhing method in Swiss albino mice. The animals were treated with the ethanolic extract of leaves and seeds of Coriandrum sativum orally at two doses of 100, 500 mg/kg body weight after electric heat and acetic acid induced pain in mice. RESULTS: The study showed that ethanolic extract of leaves and seeds of Coriandrum sativum presented significant (p<0.05) and (p<0.05) analgesic activity in mice simultaneously. The data were analyzed by one-way ANOVA followed by Dunette's multiple comparison test. The results demonstrate that ethanolic extract of leaves and seeds of Coriandrum sativum has got analgesic potential. CONCLUSION: The results demonstrate that ethanolic extract of leaves and seeds of Coriandrum sativum has got significant analgesic effect.

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ANTIANXIETY EFFECT OF ETHANOLIC EXTRACT OF FRUITS OF LIMONIA ACIDISSIMA IN SWISS ALBINO MICE

International Journal of Pharmaceutical Sciences and Medicine ◽

10.47760/ijpsm.2021.v06i08.007 ◽

2021 ◽

Vol 6 (8) ◽

pp. 104-117

Author(s):

Chouhan Vaishali ◽

Sujane Sandhya ◽

Bapna Rajendra ◽

Pyathi Asharani

Keyword(s):

Elevated Plus Maze ◽

Treatment Options ◽

Ethanolic Extract ◽

Anxiolytic Effect ◽

Ethanol Extract ◽

Active Constituent ◽

Swiss Albino Mice ◽

Plus Maze ◽

Albino Mice ◽

Limonia Acidissima

Anxiety disorder is one of the most common mental ailments exhibited by human. It is characterized by motor tension, sympathetic hyperactivity and apprehension and vigilance syndromes. A part from very few chemical remedies available like benzodiazepine and serotonin modulators, not much treatment options are at hand that safely and effectively alleviate anxiety. The ethanol extract of the fruits of plant Limonia acidissima was evaluated for its anti-anxiety activity in swiss albino mice at dose 200mg/kg and 400mg/kg body weight. Anti-anxiety was assessed by using elevated plus maze (EPM) and light and dark model methods. The ethanolic extract exhibit anxiolytic effect in experimental mice. So it is supports the use of Limonia acidissima as anxiolytic agents. Further investigation should be made to elucidate the active constituent of responsible for the activity.

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Evaluation of Antidepressant Activity of Ethanolic Extract of Alangium Salvifolium Leaves in Swiss Albino Mice

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1125 ◽

2017 ◽

Vol 10 (1) ◽

pp. 427-433 ◽

Cited By ~ 1

Author(s):

Shashikumara Shashikumara ◽

Prathima. C ◽

Mohammed Sibgatullah

Keyword(s):

Ethanolic Extract ◽

Antidepressant Activity ◽

Swiss Albino Mice ◽

Albino Mice

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EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA ROOT L. ON ACUTE RESTRAINT STRESS-INDUCED ANXIETY AND DEPRESSION IN SWISS ALBINO MICE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.27180 ◽

2018 ◽

Vol 11 (10) ◽

pp. 182 ◽

Cited By ~ 1

Author(s):

Shashikumara Shashikumara ◽

Prathima C ◽

Amrutheswari B

Keyword(s):

Restraint Stress ◽

Forced Swim Test ◽

Ethanolic Extract ◽

Antidepressant Activity ◽

Phytochemical Analysis ◽

Mimosa Pudica ◽

Swiss Albino Mice ◽

Acute Restraint Stress ◽

Immobility Time ◽

Albino Mice

Objective: The present study is undertaken to study the ameliorative effects of ethanolic extract of Mimosa pudica root (EMPR) on stress-induced anxiety and depressive-like behavior in Swiss albino mice.Methods: The animals were subjected to acute restraint stress (ARS) for 7 days, and on the 8th day after drugs administration, the antianxiety effect was evaluated using elevated plus maze (EPM) test. Antidepressant activity was evaluated by animal despair models-forced swim test and tail suspension test. Phytochemical analysis of the extract was also conducted.Results: EMPR (1000 and 2000 mg/kg) and the combined test groups have shown significant antianxiety effects similar to the standard diazepam as indicated by an improved open arm exploratory behavior in EPM model. EMPR also significantly reduced the immobility time in the animal despair models tested.Conclusion: Results suggest that EMPR possesses significant anxiolytic and antidepressant activity in male Swiss albino mice.

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