Effect of Vitamin D Status on Clinical Pregnancy Rate in Case of Intracytoplasmic Sperm Injection (ICSI)

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Gebriel AEMA ◽  
Hassan FI ◽  
Abdel Latif EM ◽  
Hassan EA ◽  
Aref MI
Keyword(s):  
Vitamin D ◽  
Pregnancy Rate ◽  
Intracytoplasmic Sperm Injection ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Vitamin D Status

The use of intracytoplasmic sperm injection for the treatment of severe and extreme male infertility

1995 ◽  
Vol 7 (2) ◽  
pp. 237 ◽  
Author(s):  
H Bourne ◽  
N Richings ◽  
O Harari ◽  
W Watkins ◽  
AL Speirs ◽  
...  
Keyword(s):  
Male Infertility ◽  
Pregnancy Rate ◽  
Intracytoplasmic Sperm Injection ◽  
Fertilization Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Male Factor ◽  
Osmotic Swelling ◽  
Fresh Embryos ◽  
Normal Fertilization

The outcome of treatment by intracytoplasmic sperm injection (ICSI) is described for patients with severe male infertility. In 296 consecutive cycles, a normal fertilization rate of 69% was achieved with 288 cycles (97%) resulting in embryos suitable for transfer. A total of 32 clinical pregnancies were achieved from the transfer of fresh embryos (clinical pregnancy rate of 12% per transfer) and an additional 44 clinical pregnancies were obtained after the transfer of frozen-thawed embryos (clinical pregnancy rate of 16% per transfer). Overall, 57 of the 76 pregnancies were ongoing or delivered. An analysis of outcome in 5 male factor subgroups revealed no significant differences in pregnancy and implantation rates between the categories. However, the fertilization rate was significantly lower in patients with oligoasthenoteratozoospermia and significantly higher in those patients for whom epididymal sperm were used for insemination. The treatment of patients with extreme male infertility is also described; normal fertilization and embryo development were obtained using ICSI in patients with mosaic Klinefelter's syndrome, severe sperm autoimmunity, round-headed acrosomeless sperm (globozoospermia), completely immotile sperm selected by hypo-osmotic swelling and sperm isolated from testicular biopsies. Three ongoing pregnancies were obtained from 6 patients for whom testicular sperm were used. These results demonstrate the value of ICSI in the management of severe male infertility, however, the treatment of some types of extreme male infertility using ICSI may be limited.

scholarly journals Intracytoplasmic sperm injection with fresh versus cryopreserved testicular sperm in azoospermic patients

2019 ◽  
Vol 24 (1) ◽  
Author(s):  
Kani M. Falah
Keyword(s):  
Pregnancy Rate ◽  
Live Birth ◽  
Intracytoplasmic Sperm Injection ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Fertilization Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Obstructive Azoospermia ◽  
Testicular Sperm

Abstract Background The purpose of this study is to compare the outcome of intracytoplasmic sperm injection (ICSI) using fresh sperm versus frozen-thawed sperm in both obstructed and non-obstructed azoospermias. This retrospective study included 159 ICSI cycles from 126 couples. In 91 obstructed azoospermia cases, 66 cycles were treated with fresh testicular sperm and 25 cycles were treated with frozen-thawed testicular samples. In 68 non-obstructed azoospermia cases, 32 cycles were treated with fresh testicular sperm and 36 cycles were treated with frozen-thawed testicular sperm, and the main measure and outcomes calculated are fertilization rate, clinical pregnancy, and live birth rate. Results In case of obstructed azoospermia, there were no statistically significant differences between fresh sperm and frozen-thawed testicular sperm used for ICSI regarding fertilization rate, clinical pregnancy rate, and live birth rate as shown (57%, 47%, 0.093 p value; 23.7%, 17.4%, 0.54 p value; and 11.9%, 8.7%, 0.68 p value, respectively). Non-obstructed azoospermia cases also show no significant differences in fertilization rate (37%, 36%, 0.91 p value), clinical pregnancy rate (20%, 14.3%, 0.58 p value), and live birth rate (4%, 3.6%, 0.93 p value). Conclusion Cryopreservation of testicular sperm is reliable if carried out before ovulation induction especially in cases with non-obstructive azoospermia

scholarly journals Effect of vitamin D supplementation on assisted reproduction technology (ART) outcomes and underlying biological mechanisms: protocol of a randomized clinical controlled trial. The “supplementation of vitamin D and reproductive outcome” (SUNDRO) study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Alessio Paffoni ◽  
Edgardo Somigliana ◽  
Veronica Sarais ◽  
Stefania Ferrari ◽  
Marco Reschini ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnancy Rate ◽  
Causal Relation ◽  
Controlled Trial ◽  
Competent Authority ◽  
Vitamin D Supplementation ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Female Fertility ◽  
Controlled Study

Abstract Background Vitamin D plays an important role in human physiology and pathology. The receptor for vitamin D regulates 0.5–5% of the human genome. Accordingly, vitamin D insufficiency has been shown to increase the risk of several diseases. In recent years, based on growing evidence, on a role of vitamin D has been also postulated in reproductive health both in animals and humans, especially in female fertility female fertility. In vitro fertilization success was shown to be higher in women with appropriate reserves of vitamin D. However a causal relation has not been demonstrated and randomized controlled trials testing the effectiveness of vitamin D supplementation in IVF are warranted. Methods This is a multicenter randomized double blinded placebo controlled study aimed at determining the benefits of vitamin D [25(OH)D] supplementation in improving clinical pregnancy rate in women undergoing IVF. Eligible women with a serum level of 25-hydroxyvitamin D [25(OH)D] < 30 ng/ml will be randomized. Recruited women will be given the drug (either 600,000 IU of 25(OH) D or placebo in a single oral administration) at the time of randomization. Two centres will participate and the sample size (700 women) is foreseen to be equally distributed between the two. Patients will be treated according to standard IVF protocols. Discussion The primary aim of the study is the cumulative clinical pregnancy rate per oocyte retrieval. Clinical pregnancy is defined as the presence of at least one intrauterine gestational sac with viable foetus at first ultrasound assessment (3 weeks after a positive human chorionic gonadotropin [hCG] assessment). Secondary outcomes include: 1) clinical and embryological variables; 2) oocyte and endometrium quality at a molecular level. To investigate this latter aspect, samples of cumulus cells, follicular and endometrial fluids will be obtained from a subgroup of 50 age-matched good-prognosis cases and controls. Trial registration The protocol was included in EudraCT on 22nd September 2015 with the registration number assigned ‘2015-004233-27’; it was submitted through the database of the Italian “Osservatorio Nazionale della Sperimentazione Clinica (OsSC)” - (National Monitoring Centre of Clinical Trials) to the National Competent Authority on 8th March 2016 and approved on 23rd June 2016.

scholarly journals Preimplantation Genetic Testing for Aneuploidies Improve the Clinical Pregnancy Outcome of Patients With AZFc Microdeletion

2021 ◽  
Author(s):  
xiliang wang ◽  
Yankun Wang ◽  
kaibo hou ◽  
dongmei hao ◽  
jinyan zhang ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Pregnancy Rate ◽  
Live Birth ◽  
Intracytoplasmic Sperm Injection ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Preimplantation Genetic Testing ◽  
Morphological Criteria

Abstract BackgroundMicrodeletions of AZF are the most common factor causing male infertility except Klinefelter syndrome. AZF patients are able to father babies through intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF), and the ICSI embryos for IVF can be scored based on morphological criteria. However, the clinical pregnancy rate and the live birth rate are unsatisfactory.ResultsHere, we investigated the outcomes of using preimplantation genetic testing for aneuploidies (PGT-A) in families with AZFc microdeletions. A total of 26 intracytoplasmic sperm injection (ICSI) cycles were performed in 22 families, 25 ICSI cycles were performed, and 81 embryos underwent PGT-A. Among them, 48 were euploid embryos (23 females and 25 males), 30 were aneuploid embryos, and three embryos did not meet the quality control standards. Thirteen ICSI cycles with female euploid embryos and one ICSI cycle with male euploid embryos entered the stage of embryo implantation. Finally, the clinical pregnancy rate was 100% (14/14), and the live birth rate was 85.7% (12/14).ConclusionCompared with other published results, PGT-A increased the chance of fertility in AZFc microdeletion patients.

Sign in / Sign up

Export Citation Format

Share Document