scholarly journals Changes in serum prolactin level during intracytoplasmic sperm injection, and effect on clinical pregnancy rate: a prospective observational study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ahmed Kamel ◽  
Ayman A. Halim ◽  
Mohamed Shehata ◽  
Salwa AlFarra ◽  
Yahia El-faissal ◽  
...  
Keyword(s):  
Observational Study ◽  
Pregnancy Rate ◽  
Intracytoplasmic Sperm Injection ◽  
Prolactin Level ◽  
Prospective Observational Study ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Serum Prolactin ◽  
Serum Prolactin Level

scholarly journals A Study of Thyroid Profile in Patients with Benign Breast Disease

2019 ◽  
Vol 10 (2) ◽  
pp. 125-130
Author(s):  
Amreen Faruq ◽  
MNA Alam ◽  
F Afsana ◽  
M Haque
Keyword(s):  
Observational Study ◽  
Prolactin Level ◽  
Thyroid Dysfunction ◽  
Prospective Observational Study ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Serum Prolactin ◽  
Serum Prolactin Level ◽  
Medical College ◽  
Thyroid Profile

Background: To observe the association between thyroid dysfunction and benign breast disease. Methods: Prospective observational study conducted in the surgical outpatient department on female patients with benign breast disease from April 2017 to April 2018. Results: Among the 208 female subjects included in the study 14.9% had hypothyroidism and 87.5% were completely symptom free when treated with Thyroxin replacement. Serum Prolactin level was also measured in all the subjects and hyperprolactinemia found in 4.8% with 50% associated with hypothyroidism. Conclusion: Thyroid profile may serve as a useful investigation in the treatment of patients with benign breast disease. Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 125-130

The use of intracytoplasmic sperm injection for the treatment of severe and extreme male infertility

1995 ◽  
Vol 7 (2) ◽  
pp. 237 ◽  
Author(s):  
H Bourne ◽  
N Richings ◽  
O Harari ◽  
W Watkins ◽  
AL Speirs ◽  
...  
Keyword(s):  
Male Infertility ◽  
Pregnancy Rate ◽  
Intracytoplasmic Sperm Injection ◽  
Fertilization Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Male Factor ◽  
Osmotic Swelling ◽  
Fresh Embryos ◽  
Normal Fertilization

The outcome of treatment by intracytoplasmic sperm injection (ICSI) is described for patients with severe male infertility. In 296 consecutive cycles, a normal fertilization rate of 69% was achieved with 288 cycles (97%) resulting in embryos suitable for transfer. A total of 32 clinical pregnancies were achieved from the transfer of fresh embryos (clinical pregnancy rate of 12% per transfer) and an additional 44 clinical pregnancies were obtained after the transfer of frozen-thawed embryos (clinical pregnancy rate of 16% per transfer). Overall, 57 of the 76 pregnancies were ongoing or delivered. An analysis of outcome in 5 male factor subgroups revealed no significant differences in pregnancy and implantation rates between the categories. However, the fertilization rate was significantly lower in patients with oligoasthenoteratozoospermia and significantly higher in those patients for whom epididymal sperm were used for insemination. The treatment of patients with extreme male infertility is also described; normal fertilization and embryo development were obtained using ICSI in patients with mosaic Klinefelter's syndrome, severe sperm autoimmunity, round-headed acrosomeless sperm (globozoospermia), completely immotile sperm selected by hypo-osmotic swelling and sperm isolated from testicular biopsies. Three ongoing pregnancies were obtained from 6 patients for whom testicular sperm were used. These results demonstrate the value of ICSI in the management of severe male infertility, however, the treatment of some types of extreme male infertility using ICSI may be limited.

scholarly journals Intracytoplasmic sperm injection with fresh versus cryopreserved testicular sperm in azoospermic patients

2019 ◽  
Vol 24 (1) ◽  
Author(s):  
Kani M. Falah
Keyword(s):  
Pregnancy Rate ◽  
Live Birth ◽  
Intracytoplasmic Sperm Injection ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Fertilization Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Obstructive Azoospermia ◽  
Testicular Sperm

Abstract Background The purpose of this study is to compare the outcome of intracytoplasmic sperm injection (ICSI) using fresh sperm versus frozen-thawed sperm in both obstructed and non-obstructed azoospermias. This retrospective study included 159 ICSI cycles from 126 couples. In 91 obstructed azoospermia cases, 66 cycles were treated with fresh testicular sperm and 25 cycles were treated with frozen-thawed testicular samples. In 68 non-obstructed azoospermia cases, 32 cycles were treated with fresh testicular sperm and 36 cycles were treated with frozen-thawed testicular sperm, and the main measure and outcomes calculated are fertilization rate, clinical pregnancy, and live birth rate. Results In case of obstructed azoospermia, there were no statistically significant differences between fresh sperm and frozen-thawed testicular sperm used for ICSI regarding fertilization rate, clinical pregnancy rate, and live birth rate as shown (57%, 47%, 0.093 p value; 23.7%, 17.4%, 0.54 p value; and 11.9%, 8.7%, 0.68 p value, respectively). Non-obstructed azoospermia cases also show no significant differences in fertilization rate (37%, 36%, 0.91 p value), clinical pregnancy rate (20%, 14.3%, 0.58 p value), and live birth rate (4%, 3.6%, 0.93 p value). Conclusion Cryopreservation of testicular sperm is reliable if carried out before ovulation induction especially in cases with non-obstructive azoospermia

scholarly journals Myoinositol with Metformin and Myoinositol alone in infertile PCOS women undergoing ovulation induction cycles: A comparative study

2021 ◽  
pp. 1-10
Author(s):  
Pramod Gade ◽  
Aher Gautam S ◽  
Vazifdar Sharmeen
Keyword(s):  
Pregnancy Rate ◽  
Prospective Observational Study ◽  
Outcome Measure ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Single Drug ◽  
Group A ◽  
The Difference ◽  
Group B ◽  
Hormonal Levels

Background: This was a prospective observational study conducted over a twelve-month duration in our institute to compare the combined effect of metformin and myoinositol with metformin alone. Method: A total of sixty patients were included in the study, and they were divided into two groups depending on whether they were given the combination or the single drug. Group A (n=30) was given Myoinositol 600 mg+Metformin 500 mg thrice a day, and Group B ( n=30) was given only Myoinositol 600 mg thrice a day. The outcome measure was clinical pregnancy rate and improvement in clinical and hormonal parameters after drug therapy. Results: BMI (p<0.01), modified Ferriman Gallaway score (p>0.05), and the was a significant improvement in the hormonal parameters (LH,FSH) in both the groups and the levels were found to be comparable after a period of 6 months. The clinical pregnancy rate after six cycles of ovulation was significantly higher in Group A as compared to Group B. In Group A, the total clinical pregnancy rate was 43.33%, and in Group B, it was 26.67%, respectively, and the end of 6 months and the difference was statistically significant (p = <0.01) Conclusion: Equal response in reduction of hormonal levels and clinical and laboratory parameters were seen in both groups, while better results in terms of clinical fertility rates were observed in the group that was given a combination of myoinositol with metformin.

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