MAOA Gene Associated with Aggressive Behavior in Humans

AbstractBackgroundAn astonishing observation is that aggressive behavior is actually a highly heritable. Recent experimental work and behavior research has linked individual variation in a functional polymorphism of the monoamine oxidase-A gene (MAOA) to the occurrence of anger-driven aggression. Aggressive antisocial and violent behavior has become a regularly debated topic in the scientific community; the impending question is what is the source of aggressive behavior, is it genetic or environmental or is it just an individual choice. This study aims to analyses the SNPs found in MAOA gene and it is possible association to aggressive behavior.MethodVarious bioinformatics software (SIFT, PolyPhen-2, PROVEAN, SNAP22, SNP&GO and PMut)is used to analyses the SNPs within the MAOA gene to study the structural and functional implication on the associated protein, which is further clarified using chimera software. Then gene-gene interaction is studied with geneMANIA software. Furthermore, conservation and annotation studies were done through the ConSurf server and Variant Effect Predictor (VEP) respectively.ResultSix missense SNPs were found to affect the structural and functional prospect of MAOA protein.ConclusionGenetic mutation within MAOA is likely to be associated with aggressive behavior; this will enrich future management and screening possibilities for this behavior.

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Identification of Single Nucleotide Polymorphisms in Porcine MAOA Gene Associated with Aggressive Behavior of Weaned Pigs after Group Mixing

Animals ◽

10.3390/ani9110952 ◽

2019 ◽

Vol 9 (11) ◽

pp. 952 ◽

Cited By ~ 1

Author(s):

Ruonan Chen ◽

Qingpo Chu ◽

Chunyan Shen ◽

Xian Tong ◽

Siyuan Gao ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Aggressive Behavior ◽

Promoter Activity ◽

Monoamine Oxidase A ◽

Luciferase Reporter ◽

Nucleotide Polymorphisms ◽

Weaned Pigs ◽

Single Nucleotide ◽

Mutant Genotype ◽

Maoa Gene

Understanding the genetic background underlying the expression of behavioral traits has the potential to fasten the genetic progress for reduced aggressive behavior of pigs. The monoamine oxidase A (MAOA) gene is known as the “warrior” gene, as it has been previously linked to aggressive behavior in humans and livestock animals. To identify single nucleotide polymorphisms in porcine MAOA gene associated with aggressive behavior of pigs, a total of 500 weaned pigs were selected and mixed in 51 pens. In each pen, two aggressive and two docile pigs (a total of 204 pigs) were selected based on their composite aggressive score (CAS). Ear tissue was sampled to extract genomic DNA. Constructs containing variable lengths of truncated porcine MAOA promoter were used to determine the promoter activity by a dual luciferase reporter system. The core promoter region was located at −679 bp to −400 bp. A total of nine single nucleotide polymorphisms (SNPs) in MAOA gene were genotyped, of which six SNPs had significant differences (p < 0.05) in allele frequency between the aggressive and docile pigs. Linkage disequilibrium and association analyses showed that the pigs inherited the wild genotypes showed more aggressive behavior (p < 0.05) than pigs with the mutant genotypes of the four linked SNPs, rs321936011, rs331624976, rs346245147, and rs346324437. In addition, pigs of GCAA haplotype were more (p < 0.05) aggressive than the pigs with GCGA or ATGG haplotype. The construct containing the wild genotype GG of rs321936011 had lower (p = 0.031) promoter activity compared to the mutant genotype AA. These results suggest that the four linked SNPs in MAOA gene could be considered as a molecular marker for behavioral trait selection in pigs.

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Assessing Social Skills in Health Professional Services

European Journal of Psychological Assessment ◽

10.1027/1015-5759.21.3.173 ◽

2005 ◽

Vol 21 (3) ◽

pp. 173-181

Author(s):

Francisco Gil ◽

Jesús Sanz ◽

María Paz García-Vera ◽

José M. León ◽

Silvia Medina ◽

...

Keyword(s):

Social Skills ◽

Health Services ◽

Health Professional ◽

Aggressive Behavior ◽

Psychometric Properties ◽

Internal Consistency ◽

Intervention Program ◽

Professional Services ◽

Quality Of Health Services

Abstract. The quality of health services depends on the contribution of all the professionals involved in the system, including certain groups, usually forgotten and underrated, such as the health-transport technicians (HTT). With the aim of improving this group's performance, an intervention program, focusing on the development of the workers' technical and social skills, was designed in a collective of enterprises. Information about the first stage of this program, consisting of the assessment of these workers' social skills, is offered in this study. A specific questionnaire was developed: The Health-Transport Technicians Social Skills Questionnaire (HTT-SSQ), made up of three scales (assertive, passive, and aggressive behavior). It was administered to a large sample (N = 530) from the above-mentioned association. The psychometric properties of the questionnaire were analyzed, with quite satisfactory indexes of internal consistency and factor validity, and the group's deficiencies (excess or deficit) were evaluated.

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The Hitman Study

European Psychologist ◽

10.1027/1016-9040/a000010 ◽

2010 ◽

Vol 15 (2) ◽

pp. 99-108 ◽

Cited By ~ 76

Author(s):

Christopher J. Ferguson ◽

Stephanie M. Rueda

Keyword(s):

Experimental Study ◽

Young Adults ◽

Aggressive Behavior ◽

Video Game ◽

Real Life ◽

Mood Management ◽

Video Game Play ◽

Video Game Playing ◽

Violent Video Game ◽

The Social

This article explores commonly discussed theories of violent video game effects: the social learning, mood management, and catharsis hypotheses. An experimental study was carried out to examine violent video game effects. In this study, 103 young adults were given a frustration task and then randomized to play no game, a nonviolent game, a violent game with good versus evil theme (i.e., playing as a good character taking on evil), or a violent game in which they played as a “bad guy.” Results indicated that randomized video game play had no effect on aggressive behavior; real-life violent video game-playing history, however, was predictive of decreased hostile feelings and decreased depression following the frustration task. Results do not support a link between violent video games and aggressive behavior, but do suggest that violent games reduce depression and hostile feelings in players through mood management.

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