scholarly journals Improved Development Cycle for 8-bit FPGA-Based Soft-Macros Targeting Complex Algorithms

2021 ◽  
Vol 25 (12) ◽  
pp. 21-35
Author(s):  
Ehsan Ali ◽  
Wanchalerm Pora
Keyword(s):  
Development Cycle

Application research of automobile modeling optimization design based on virtual reality technology

2021 ◽  
pp. 1-13
Author(s):  
Jingfeng Shao ◽  
Zhigang Yang
Keyword(s):  
Virtual Reality ◽  
Optimization Design ◽  
Evaluation Process ◽  
Design Stage ◽  
Virtual Reality Technology ◽  
Automobile Design ◽  
Field Of Vision ◽  
Development Cycle ◽  
Design Cycle ◽  
Long Time

Automobile styling design is an important part of the design chain. In the traditional automobile modeling evaluation, the process of project evaluation is more in-depth, and designers exchange ideas. Different designers have different evaluations of automobile styling. The evaluation process lasts a long time, which leads to the design cycle being too long and the efficiency of automobile modeling evaluation is greatly reduced. The introduction of virtual reality in automobile modeling evaluation can effectively optimize the evaluation process and promote the rapid adjustment of the model on the basis of development. From the virtual reality system based on mechanical engineering, we only need the parameters of the car model to observe the actual situation through VR technology, and use the measurement tools to directly and accurately evaluate the driver’s field of vision. Through the application of virtual reality technology in the automobile design stage, the interactive and network-based remote research on automobile modeling will also make the automobile design process more convenient, easier to communicate with designers, and reduce the development cycle and cost of automobile design.

scholarly journals Development and Bio-Predictive Evaluation of Biopharmaceutical Properties of Sustained-Release Tablets with a Novel GPR40 Agonist for a First-in-Human Clinical Trial

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 804
Author(s):  
Ewelina Juszczyk ◽  
Kamil Kisło ◽  
Paweł Żero ◽  
Ewa Tratkiewicz ◽  
Maciej Wieczorek ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sustained Release ◽  
Development Strategy ◽  
Matrix Tablets ◽  
Matrix Tablet ◽  
Mechanical Agitation ◽  
Development Cycle ◽  
Dissolution Tests ◽  
Sustained Release Tablets ◽  
Biopharmaceutical Properties

Sustained-release (SR) formulations may appear advantageous in first-in-human (FIH) study of innovative medicines. The newly developed SR matrix tablets require prolonged maintenance of API concentration in plasma and should be reliably assessed for the risk of uncontrolled release of the drug. In the present study, we describe the development of a robust SR matrix tablet with a novel G-protein-coupled receptor 40 (GPR40) agonist for first-in-human studies and introduce a general workflow for the successful development of SR formulations for innovative APIs. The hydrophilic matrix tablets containing the labeled API dose of 5, 30, or 120 mg were evaluated with several methods: standard USP II dissolution, bio-predictive dissolution tests, and the texture and matrix formation analysis. The standard dissolution tests allowed preselection of the prototypes with the targeted dissolution rate, while the subsequent studies in physiologically relevant conditions revealed unwanted and potentially harmful effects, such as dose dumping under an increased mechanical agitation. The developed formulations were exceptionally robust toward the mechanical and physicochemical conditions of the bio-predictive tests and assured a comparable drug delivery rate regardless of the prandial state and dose labeled. In conclusion, the introduced development strategy, when implemented into the development cycle of SR formulations with innovative APIs, may allow not only to reduce the risk of formulation-related failure of phase I clinical trial but also effectively and timely provide safe and reliable medicines for patients in the trial and their further therapy.

scholarly journals THE RESEARCH DOMAIN OF PRODUCT-SERVICE SYSTEMS AND VOICE OF THE CUSTOMER: A SYSTEMATIC MAPPING

2021 ◽  
Vol 1 ◽  
pp. 3101-3110
Author(s):  
Carl Nils Konrad Toller ◽  
Marco Bertoni
Keyword(s):  
Research Area ◽  
Service Systems ◽  
Future Research ◽  
Systematic Mapping ◽  
Progressive Development ◽  
Development Cycle ◽  
Product Service ◽  
Product Service Systems ◽  
Research Domain ◽  
Voice Of The Customer

AbstractProduct-Service Systems (PSS) have emerged as a key concept to meet the societal and market trends of increasing customer needs through the entire life-cycle. Unfortunately, several companies are struggling with getting revenues from service investments and translating 'real needs' to design improvements. The demand of the designer to go beyond the Voice of the Customer (VoC) is evident. This paper aims to map the interventions proposed by research in the area of PSS and VoC. Using a systematic mapping approach, the research domain was analyzed with regards to context and interventions. The results show a progressive development in the research area with a focus on the specification and realization of needs. A gap exists in connecting the engineers with 'real needs' and integrating the customer as a natural part of the entire development cycle of a PSS. By performing a systematic mapping, future research can be more focused and hopefully increasing its impact.

scholarly journals Sexuality in Neurospora crassa I. Mutations to male sterility

1972 ◽  
Vol 19 (3) ◽  
pp. 191-204 ◽  
Author(s):  
J. Weijer ◽  
N. V. Vigfusson
Keyword(s):  
Neurospora Crassa ◽  
Male Sterility ◽  
Wide Spectrum ◽  
Female Parent ◽  
Behaviour Pattern ◽  
Type Locus ◽  
Development Cycle ◽  
Ultraviolet Light Irradiation ◽  
Mutant Strains ◽  
Aberrant Segregation

SUMMARYMutations giving rise to sexual sterility were induced in Neurospora crassa macroconidia by ultraviolet-light irradiation. Thirty mutants were isolated on the basis of their male sterility in crosses with a wild-type strain. When used as the male parent these mutants exhibited a wide spectrum of sexual behaviour patterns ranging from the production of only small brown protoperithecia (complete male sterility) to the production of large and normally pigmented perithecia but with an undeveloped ostiole and very few if any spores. For many of the mutants the behaviour pattern is different when the strain is used as the female parent. Segregation data reveal that none of these mutants represent mutations of the mating-type locus. These findings suggest that the sexual development cycle is blocked at various stages in the different mutant strains. All attempts to restore fertility by supplying various additives to the medium or by varying the incubation time and temperature were unsuccessful. Conidial viability tests carried out on many of the strains revealed no abnormality in this respect. The aberrant segregation patterns exhibited by many of the mutants are discussed.

Rapid Control Prototyping Design of DSP-Based Motion Controller

2011 ◽  
Vol 383-390 ◽  
pp. 308-314
Author(s):  
Lin Li ◽  
Zhi Ming Peng ◽  
Bi Cong Zhang ◽  
Zhang Tie
Keyword(s):  
Code Generation ◽  
Automatic Code Generation ◽  
Motion Controller ◽  
Application System ◽  
Pid Algorithm ◽  
Development Platform ◽  
Development Cycle ◽  
Rapid Control ◽  
Rapid Control Prototyping ◽  
Automatic Code

This paper presents a Rapid Control Prototyping (RCP) development platform based on Matlab/Simulink, Real-Time Workshop and Embedded Target for C2000 and DSP development board. It also designs TMS320F2812 DSP-based motion controller under the proposed RCP. The controller using saturated integral PID algorithm produces PWM signal to control DC motor. Experimental results show that the designed controller can control motor accurately. Engineers can complete all design tasks such as modeling, automatic code generation, and download, running and parameters adjustment on this RCP platform when developing DSP application system. Thus the proposed RCP can shorten the DSP development cycle and improve the portability and modularity of program.

Transient Thermal Analysis for the Automotive Underhood and Underbody Components

2013 ◽  
Author(s):  
Yu Hsien Wu ◽  
Kumar Srinivasan ◽  
Steven Patterson ◽  
Emmanuel Bot
Keyword(s):  
Thermal Analysis ◽  
Thermal Management ◽  
Dissimilar Materials ◽  
Thermal Mass ◽  
New Approach ◽  
The Past ◽  
Full Vehicle ◽  
Development Cycle ◽  
Transient Thermal ◽  
Steady State Solutions

The transient thermal simulation is an important part of thermal management development for new vehicle architectures. Different techniques have been studied in the past to address this coupled conduction/convection/radiation problem. In order to fully capture the transient thermal behavior of various underhood and underbody components, it is also necessary to accurately model the thermal mass of each part and the thermal links between dissimilar materials. The paper will outline a new, efficient methodology for this type of thermal analysis that shows acceptable results for complex full vehicle thermal analysis without sacrificing accuracy. The methodology is based on approximating the transient convective field with intermittent steady state solutions. The paper will present results from this new approach and compare them with fully transient simulation results as well as experimental data. The new methodology can be optimized to significantly reduce simulation run times without sacrificing accuracy and to be more practical for application in the vehicle development cycle.

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