scholarly journals Distribution, Source Appropriation, and Human Health Risk Assessment of Polycyclic Aromatic Hydrocarbons due to Consumption of Callinectes amnicola from Woji Creek in Sambreiro River

2021 ◽  
Vol 21 (05) ◽  
pp. 245-253
Author(s):  
Owhonda Chikeru Ihunwo ◽  
Millicent Uzoamaka Ibezim-Ezeani
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Surface Water ◽  
Cancer Risk ◽  
Aromatic Hydrocarbons ◽  
Age Groups ◽  
Excess Cancer Risk ◽  
Study Results ◽  
Polycyclic Aromatic ◽  
Toxicity Equivalent ◽  
Risk Of Cancer

Crabs (Callinectes amnicola) and surface water sampled from the Sambreiro River, Rivers State of Nigeria, were analyzed for polycyclic aromatic hydrocarbons concentrations for four months (December (2019), January, February, and March (2020)). Excess cancer risk due to ingestion of the crabs was assessed for individuals of the age groups: 3 to < 6 years, 16 to < 21 years, 21 to < 50 years, and ≥ 50 years. Although concentrations in surface water (ΣPAH16 = 0.125±011 mg/L) were lower than in the previous study, results obtained revealed considerably higher concentrations of aromatic hydrocarbons in crab tissues (ΣPAH16=10.659±2.399 mg/kg). Hepatopancreas (ΣPAH16=6.590±0.266 mg/kg) accumulated the highest concentration of hydrocarbons followed by the gills (ΣPAH16=2.349±0.029 mg/kg), then the muscles (ΣPAH16=1.720±0.320 mg/kg). Source appropriation results revealed a combination of the petrogenic and pyrogenic contribution of hydrocarbons in the crab tissues. The trend for the toxicity equivalent quotient was hepatopancreas > muscles > gills; while the excess cancer risk exceeded for all age groups, suggesting that humans are at risk of cancer arising from the ingestion of crab species from this study location.

scholarly journals Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in Commonly Consumed Shellfish from Kula, Rivers State, Nigeria

2019 ◽  
Vol 8 (3) ◽  
pp. 58
Author(s):  
A. Dokubo ◽  
F. U. Igwe
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Cancer Risk ◽  
Aromatic Hydrocarbons ◽  
Human Health Risk ◽  
Daily Intake ◽  
Hazard Index ◽  
Potential Health ◽  
Excess Cancer Risk ◽  
Polycyclic Aromatic ◽  
Rivers State

Polycyclic Aromatic Hydrocarbons (PAHs) were assessed in shellfishes (whelk, oyster and periwinkle) from Kula, Rivers State, Nigeria. The PAHs determination was done using gas chromatography (GC) coupled with flame ionization detector (FID) (Hewlett Packard, Wilmington, DE, USA), powered with HP chemstation Rev. A09:01 (10206) software. Human health risk assessment models based on United States Environmental Protection Agency (USEPA) was used to characterize risks of PAHs exposure to non cancer (Hazard Index) while and excess cancer risk (ECR). From the results, Benzo [a] Anthrancene (BaA) had highest concentrations in whelk (0.689±0.003) and Periwinkle (0.930±0.001) while Naphthalene had highest concentration in oyster (2.000±0.000). The Total concentration of PAHs in µ g/kg for whelk, oyster and periwinkle were 1.797±0.013, 3.977 ±0.024 and 1.564±0.017 while the estimated daily intake (EDI) of PAHs (mg/kg/day) via consumption of shell fish ranged from 2.00x10-4 to 6.40x10-2, 7.0x10-4 to 1.86 x10-1 and 0 to 8.64x10-2 far above oral reference dose (RFD) respectively. The toxic equivalents (TEQs) values were 1.276x10-4, 1.252x10-4 and 4.034x10-4 for whelk, oyster and periwinkle respectively, were significantly (p<0.05) higher than the screening value (SV) for shellfish 1.81x10-5mg/kg. The estimated excess cancer risk (ECR) obtained for whelk was (3.0x10-4), oyster (2.00x10-4) and periwinkle (3.24x10-4). These values were far above the USEPA acceptable (1x10-4). From this study, it can be deduced that bioaccumulation of PAHs in the shellfish is a potential health hazard to consumers. Carcinogenic indices indicated that daily Intake of contaminated shellfishes exposures the local populace to cancer risks.

scholarly journals Polycyclic Aromatic Hydrocarbons in Costal Sediments and Indian Halibuts of Asaluyeh, Kangan, Khark, Emam Hasan and Bushehr Coasts, Iran: Distribution Pattern and Health Risk Assessment

2021 ◽  
Author(s):  
Ghafour Nourian ◽  
Neamat Haghighi ◽  
Tayebeh Tabatabaei ◽  
Esmaeil Kohgardi ◽  
Abdul Pazira
Keyword(s):  
Risk Assessment ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Cancer Risk ◽  
Health Risk ◽  
Health Risk Assessment ◽  
Aromatic Hydrocarbons ◽  
Lifetime Cancer Risk ◽  
Ring Compounds ◽  
Excess Cancer Risk ◽  
Polycyclic Aromatic

Abstract A total 20 sediment and 20 Indian halibut samples were sampled from Asaluyeh, Kangan, Khark, Emam Hasan and Bushehr coast, Bushehr province, Iran for studying distribution and health risk assessment of polycyclic aromatic hydrocarbons (PAHs). PAHs were analyzed using HPLC. The mean ƩPAHs concentrations in sediment and Indian halibut samples were 6.894 ± 1.4301 and 14.807 ± 7.486 mg/kg, respectively. There was a significant positive relationship (P < 0.05) between ƩPAHs, 2–3 ring compounds, and 4 ring compounds in the sediments and Indian halibut samples. ƩPAHs concentration in sediments and Indian halibuts was higher in Asaluyeh area followed by Khark area. The values of PAHs pollution in the Bushehr province coastline were low to very high. The toxic equivalent quotient (TEQ), excess cancer risk (ECR), and the incremental lifetime cancer risk (ILCR) were applied for health risk assessment. Based on TEQ calculation, DA was a good marker in assessing PAHs related to health risk. DDI values for ∑PAHs and ∑CPAHs (carcinogenic PAHs) were also highest in Asaluyeh and Kangan, respectively. ILCR values for sediments in 10% of all stations and cumulative ECR values for Indian halibuts in all studied areas exceeded the USEPA acceptable level thus suggesting a potential cancer risk. Thus, regular monitoring of PAHs pollutants in the coastlines of Bushehr province is recommended.

scholarly journals Speculative Carcinogenicity Assessment of Polycyclic Aromatic Hydrocarbons Found in Some Anti-Diarrheal Herbal Drugs Sold in Ondo State of Nigeria

2021 ◽  
pp. 1046-1053
Author(s):  
Sunday Adewale Akintelu ◽  
Aderonke Similoluwa Folorunso ◽  
Femi Adekunle Folorunso
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Cancer Risk ◽  
Aromatic Hydrocarbons ◽  
Age Groups ◽  
Herbal Drugs ◽  
Herbal Drug ◽  
Total Pahs ◽  
Diagnostic Indices ◽  
Polycyclic Aromatic ◽  
Group Distribution

The conviction that herbal drugs have enormous health benefits has led to increase the rate of their consumption by Nigerians. The aim of this study was to assess the carcinogenic property of some popularly consumed anti-diarrheal herbal drugs via polycyclic aromatic hydrocarbons (PAHs) quantification. Three prevalent anti-diarrhea herbal drugs , Odunmo herbal drug (Hibiscus rosa-sinensis and Bacopamonnieri), Orogun herbal mixture (Hibiscus sabdariffaI and Hedera helix), and Alora herbal syrup (Aloe vera and Hibiscus sabdariffaI) were bought for the purpose of this study and they were coded as samples A, B, and C, respectively. The ultrasonic extraction of the herbal drugs was carried out using standard procedures. The crude extracts obtained were purified using a chromatographic method. The concentrations of PAHs were quantified using gas chromatography flame ionization detector (GCFID). The diagnostic indices, group distribution, toxicity equivalence and exposure dosage were estimated. The cancer risk values were theoretically speculated based on concentrations of PAHs in the tested herbal drugs, associated with the published estimates of each concentration to cause cancer and the calculated exposure doses of the anti-diarrhea herbal drug samples were within three age groups (children, Preteen and adult). The highest concentration of total PAHs was observed in sample A (58.2815mg/kg) and the lowest concentration in sample B (44.1898mg/kg), but the concentration of total PAHs in sample C was 47.4169 mg/kg. The highest percentage of carcinogenic PAHs in the anti-diarrheal herbal drugs was found in sample C (48.66%) and the lowest in sample B (38.17%). The diagnostic indices confirmed a pyrogenic source of PAHs. Group distribution of PAHs showed that the herbal drugs are weakly carcinogenic due to high concentrations of low and moderate molecular weight PAHs. The cancer risk estimated for all the age groups where below the limit established by the United State Environmental Protection Agency (USEPA) for cancer (1 x 10-6). This ascertained that the use of these herbal drugs cannot cause cancer. However, consumers of these herbal drugs should take necessary precautions as excessive intake can lead to dangerous health implications.

scholarly journals Health Risks of Structural Firefighters from Exposure to Polycyclic Aromatic Hydrocarbons: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (8) ◽  
pp. 4209
Author(s):  
Jooyeon Hwang ◽  
Chao Xu ◽  
Robert J. Agnew ◽  
Shari Clifton ◽  
Tara R. Malone
Keyword(s):  
Risk Factors ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Meta Analysis ◽  
Occupational Exposures ◽  
Fire Smoke ◽  
Polycyclic Aromatic ◽  
Pah Exposure ◽  
In Fire ◽  
Risk Of Cancer

Firefighters have an elevated risk of cancer, which is suspected to be caused by occupational and environmental exposure to fire smoke. Among many substances from fire smoke contaminants, one potential source of toxic exposure is polycyclic aromatic hydrocarbons (PAH). The goal of this paper is to identify the association between PAH exposure levels and contributing risk factors to derive best estimates of the effects of exposure on structural firefighters’ working environment in fire. We surveyed four databases (Embase, Medline, Scopus, and Web of Science) for this systematic literature review. Generic inverse variance method for random effects meta-analysis was applied for two exposure routes—dermal and inhalation. In dermal, the neck showed the highest dermal exposure increased after the fire activity. In inhalation, the meta-regression confirmed statistically significant increases in PAH concentrations for longer durations. We also summarized the scientific knowledge on occupational exposures to PAH in fire suppression activities. More research into uncontrolled emergency fires is needed with regard to newer chemical classes of fire smoke retardant and occupational exposure pathways. Evidence-based PAH exposure assessments are critical for determining exposure–dose relationships in large epidemiological studies of occupational risk factors.

scholarly journals Classroom Dust-Bound Polycyclic Aromatic Hydrocarbons in Jeddah Primary Schools, Saudi Arabia: Level, Characteristics and Health Risk Assessment

2020 ◽  
Vol 17 (8) ◽  
pp. 2779
Author(s):  
Mansour A. Alghamdi ◽  
Salwa K. Hassan ◽  
Noura A. Alzahrani ◽  
Marwan Y. Al Sharif ◽  
Mamdouh I. Khoder
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Cancer Risk ◽  
Urban Schools ◽  
Health Risks ◽  
Aromatic Hydrocarbons ◽  
Primary Schools ◽  
Residential Schools ◽  
Suburban Schools ◽  
Lifetime Cancer Risk ◽  
Polycyclic Aromatic

Data concerning polycyclic aromatic hydrocarbons (PAHs) in Jeddah’s schools, Saudi Arabia, and their implications for health risks to children, is scarce. Classroom air conditioner filter dusts were collected from primary schools in urban, suburban and residential areas of Jeddah. This study aimed to assess the characteristics of classroom-dust-bound PAHs and the health risks to children of PAH exposure. Average PAH concentrations were higher in urban schools than suburban and residential schools. Benzo (b)fluoranthene (BbF), benzo(ghi)perylene (BGP), chrysene (CRY) and Dibenz[a,h]anthracene (DBA) at urban and suburban schools and BbF, BGP, fluoranthene (FLT) and indeno (1, 2, 3, −cd)pyrene (IND) at residential schools were the dominant compounds in classroom dust. PAHs with five aromatic rings were the most abundant at all schools. The relative contribution of the individual PAH compounds to total PAH concentrations in the classroom dusts of schools indicate that the study areas do share a common source, vehicle emissions. Based on diagnostic ratios of PAHs, they are emitted from local pyrogenic sources, and traffic is the significant PAH source, with more significant contributions from gasoline-fueled than from diesel cars. Based on benzo[a]pyrene equivalent (BaPequi) calculations, total carcinogenic activity (TCA) for total PAHs represent 21.59% (urban schools), 20.99% (suburban schools), and 18.88% (residential schools) of total PAH concentrations. DBA and BaP were the most dominant compounds contributing to the TCA, suggesting the importance of BaP and DBA as surrogate compounds for PAHs in this schools. Based on incremental lifetime cancer risk (ILCingestion, ILCRinhalation, ILCRdermal) and total lifetime cancer risk (TLCR)) calculations, the order of cancer risk was: urban schools > suburban schools > residential schools. Both ingestion and dermal contact are major contributors to cancer risk. Among PAHs, DBA, BaP, BbF, benzo(a)anthracene (BaA), benzo(k)fluoranthene (BkF), and IND have the highest ILCR values at all schools. LCR and TLCR values at all schools were lower than 10−6, indicating virtual safety. DBA, BaP and BbF were the predominant contributors to cancer effects in all schools.

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