scholarly journals Head and Neck Cancer a Single Institution Experience: King Abdulaziz University

2015 ◽  
Vol 22 (3) ◽  
pp. 9-17
Author(s):  
Rolina K Al-Wassia ◽  
Nisreen A. Awad ◽  
Shadi S. Al-Khayyat ◽  
Atlal M. Abusanad ◽  
Hani Z. Al-Marzouki ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Survival Rates ◽  
Treatment Modalities ◽  
Clinical Practices ◽  
Hospital Data ◽  
Intensity Modulated ◽  
Regional Control

The purpose of this study is to assess the loco-regional control and overall survival in head and neck cancer patients, as well as evaluate the clinical benefit of intensity-modulated radiotherapy implemented in 2011 at our Hospital. Data of 117 patients between 2007 and 2014 was reviewed retrospectively. Cumulative survival and disease control rates were calculated by Kaplan-Meier product-limit actuarial method. Loco-regional control and survival rates for intensity modulated and three-dimensional conformal radiotherapy were compared by a logistic regression test. After a median follow-up of 12 months, 53 (51%) patients who underwent radical radiotherapy were free of disease, 43 (42%) with disease, and seven (7%) unknown. During this time, 31 (26%) patients died from the disease. Using actuarial estimates for the two-year follow-up, this study found that significant gains in survival were obtained by switching treatment modalities. The benchmarking gives reassurance that our results are comparable to the best clinical practices internationally.  

The Importance of Long-term Follow-up of Head and Neck Cancer Patients for Reliable Survival Analysis

2005 ◽  
Vol 133 (6) ◽  
pp. 877-881 ◽  
Author(s):  
Antonio Vitor Martins Priante ◽  
André Lopes Carvalho ◽  
Karina de Cássia Braga Ribeiro ◽  
Hirde Contesini ◽  
Luiz Paulo Kowalski
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Survival Time ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Survival Rates ◽  
Accurate Estimate ◽  
Upper Aerodigestive Tract ◽  
Lost To Follow Up

OBJECTIVE: Analyze the influence of patients lost to follow-up in estimated survival rates calculated by the Kaplan-Meier method. STUDY DESIGN: Only patients with previously untreated squamous cell carcinoma of the upper aerodigestive tract were selected. For the patients lost to follow-up anytime, the last medical evaluation date was collected to calculate the “estimate A” survival time. If the same patient returned to our outpatient clinic or further health information was obtained, the updated last information/evaluation date was also collected to calculate “estimate B” survival time. The survival curves considering “estimate A” and “B” survival rates were compared. RESULTS: The overall 5 and 10-years survival rates for all patients calculated for “estimate A” were 54.0% and 46.0%, respectively; compared with 42.8% and 28.2% when were calculated considering “estimate B” ( P < 0.001). CONCLUSION: Close follow-up of the head and neck cancer patients is essential for an accurate estimate of survival by KaplanMeier method. EBM RATING: C

Multiagent Concurrent Chemoradiotherapy for Locoregionally Advanced Squamous Cell Head and Neck Cancer: Mature Results From a Single Institution

2006 ◽  
Vol 24 (7) ◽  
pp. 1064-1071 ◽  
Author(s):  
David J. Adelstein ◽  
Jerrold P. Saxton ◽  
Lisa A. Rybicki ◽  
Ramon M. Esclamado ◽  
Benjamin G. Wood ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Primary Site ◽  
Overall Survival Rate ◽  
Regional Control

Purpose A retrospective review with long-term follow-up is reported from the Cleveland Clinic Foundation studying radiation and concurrent multiagent chemotherapy in patients with locoregionally advanced squamous cell head and neck cancer. Patients and Methods Between 1989 and 2002, 222 patients were treated with 4-day continuous infusions of fluorouracil (1,000 mg/m2/d) and cisplatin (20 mg/m2/d) during weeks 1 and 4 of either once daily or twice daily radiation therapy. Primary site resection was reserved for patients with residual or recurrent primary site disease after chemoradiotherapy. Neck dissection was considered for patients with N2 or greater disease, irrespective of clinical response, and for patients with residual or recurrent neck disease. Results With a median follow-up of 73 months, the Kaplan-Meier 5-year projected overall survival rate is 65.7%, freedom from recurrence rate is 74.0%, local control without the need for surgical resection rate is 86.7%, and overall survival rate with organ preservation is 62.2%. Including patients undergoing primary site resection as salvage therapy, the overall local control rate is 92.4%. Regional control rate at 5 years is 92.4%. Among patients with N2-3 disease, regional control was significantly better if a planned neck dissection was performed. Distant control at 5 years was achieved in 85.4% of patients and was significantly worse in patients with hypopharyngeal primary sites and patients with poorly differentiated tumors. Conclusion Concurrent multiagent chemoradiotherapy can result in organ preservation and cure in the majority of appropriately selected patients with locoregionally advanced, nonmetastatic, squamous cell head and neck cancer. Distant metastatic disease was the most common cause of treatment failure. Late functional outcomes will require further investigation.

scholarly journals Proton Therapy in the Treatment of Head and Neck Cancer

2017 ◽  
Vol 8 (2) ◽  
pp. 45-48
Author(s):  
Evangelia Katsoulakis ◽  
Natalya Chernichenko ◽  
David Schreiber
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Clinical Studies ◽  
Intensity Modulated Radiation Therapy ◽  
Added Value ◽  
Treatment Modalities ◽  
Intensity Modulated

ABSTRACT Aim To examine the value of proton therapy in relation to other treatment modalities in head and neck cancer. Review Proton therapy has evolved into more sophisticated and costly intensity-modulated proton therapy and has resulted in even greater dose reduction to normal critical structures at risk as compared with photon therapy. Early clinical studies in head and neck cancers, especially for tumors of the skull base and paranasal sinuses, suggest that proton therapy is excellent in terms of local control and is comparable to intensity-modulated radiation therapy photons but with lower rates of morbidity. Results There are many potential advantages to radiation therapy with protons. While there are many single institution studies examining the added value of protons to photon therapy, the value of proton therapy must be examined in prospective randomized clinical studies and across many subsites of head and neck cancer. Additional evidence is necessary to guide efficient clinical practice, patient selection, and tumors that are most likely to benefit from this treatment modality and justify proton therapy use given its significant cost. How to cite this article Katsoulakis E, Chernichenko N, Schreiber D. Proton Therapy in the Treatment of Head and Neck Cancer. Int J Head Neck Surg 2017;8(2):45-48.

A Case of Intrathecal Pump Therapy for Intractable Head and Neck Cancer Pain

2019 ◽  
pp. 139-144
Author(s):  
Enas Kandil
Keyword(s):  
Head And Neck Cancer ◽  
Pain Relief ◽  
Head And Neck ◽  
Neck Cancer ◽  
Treatment Modalities ◽  
Intractable Pain ◽  
Pump Therapy ◽  
Oral Pain ◽  
Carcinoma Of The Tongue

We present a case of a 34-year-old man who had refractory oral pain secondary to squamous cell carcinoma of the tongue and describe his status post multiple surgical procedures. After failing a variety of treatment modalities, an intrathecal pump (ITP) was placed in the lower cervical spine region. He was assessed at several points, initially every 2 weeks, then every 6 months and reported significant and continued pain relief with the ITP past the first 6-month follow-up and no neurological or respiratory side effects were noted. In addition to substantial pain relief, this invasive modality allowed the patient to be a candidate for further chemotherapeutic medications, which induced temporary remission and extended the patient’s life expectancy by over 4 months. Key words: Intrathecal pump, intractable pain, head and neck cancer

scholarly journals Reirradiation using robotic image-guided stereotactic radiotherapy of recurrent head and neck cancer

2016 ◽  
Vol 57 (3) ◽  
pp. 288-293 ◽  
Author(s):  
Hideya Yamazaki ◽  
Mikio Ogita ◽  
Kengo Himei ◽  
Satoaki Nakamura ◽  
Gen Suzuki ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Survival Rates ◽  
Special Focus ◽  
Institutional Review ◽  
Lower Response Rate ◽  
Recurrent Head

Abstract The purpose of this study was to examine the prognosis for patients with head and neck cancer after reirradiation using Cyberknife stereotactic body irradiation with special focus on mucosal ulceration. We conducted a retrospective multi-institutional review of 107 patients with previously irradiated head and neck cancer. The median follow-up time for all patients was 15 months, and the 2-year overall survival rate was 35%. Significant prognostic factors for overall survival were primary site (nasopharynx versus other sites), presence of ulceration, and PTV volume. Detailed analysis of ulceration showed a lower response rate (28%) in the ulceration (+) group than the ulceration (−) group (63%; P = 0.0045). The 2-year overall survival rates were 8% in the ulceration (+) group and 42.7% ( P = 0.0001) in the ulceration (−) group, respectively. We recorded 22 severe toxicities, including 11 patients with carotid blow-out syndrome (CBOS), which was fatal in 9 patients. CBOS occurred in 6 patients with ulceration (6/25; 24%), and 5 patients experienced CBOS without ulceration (5/82; 6%; P =0.027). In conclusion, ulceration is an important prognostic factor, not only for adverse events but also for survival after reirradiation using CyberKnife.

Neutrophilic Dermatosis of Hands as Oncological Finding: Importance of Follow-Up

ORL ◽  
2021 ◽  
pp. 1-3
Author(s):  
Jérôme R. Lechien ◽  
Daphné Delplace ◽  
Mohamad Khalife ◽  
Sven Saussez
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Paraneoplastic Syndrome ◽  
Tobacco Consumption ◽  
Neutrophilic Dermatosis ◽  
Pharyngeal Cancer ◽  
Head And Neck Malignancy ◽  
Neck Malignancy

Neutrophilic febrile dermatosis (NFD) is a rare paraneoplastic syndrome that may be found in patients with head and neck cancer. NFD may appear before the neoplasia and may only concern the dorsal faces of the hands. This article reports the NFD findings of a patient with pharyngeal cancer, which was developed 2 years after the occurrence of NFD. The development of NFD in patient with alcohol and tobacco consumption should lead otolaryngologists and dermatologists to suspect head and neck malignancy. In cases of normal otolaryngological examination, patients have to be followed.

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