scholarly journals Modelling the Effects of Vertical Transmission in Mosquito and the Use of Imperfect Vaccine on Chikungunya Virus Transmission Dynamics

2019 ◽  
Vol 10 (04) ◽  
pp. 245-267
Author(s):  
Martins O. Onuorah ◽  
Emmanuel I. Obi ◽  
Bala G. Babangida
Keyword(s):  
Vertical Transmission ◽  
Chikungunya Virus ◽  
Virus Transmission ◽  
Transmission Dynamics

scholarly journals A Framework for Weather-Driven Dengue Virus Transmission Dynamics in Different Brazilian Regions

2021 ◽  
Vol 18 (18) ◽  
pp. 9493
Author(s):  
Leon Diniz Alves ◽  
Raquel Martins Lana ◽  
Flávio Codeço Coelho
Keyword(s):  
Vertical Transmission ◽  
Virus Transmission ◽  
Transmission Dynamics ◽  
Transmission Model ◽  
Egg Hatching ◽  
Climate Fluctuations ◽  
Dengue Transmission ◽  
Proposed Model ◽  
Environment Variables

This study investigated a model to assess the role of climate fluctuations on dengue (DENV) dynamics from 2010 to 2019 in four Brazilian municipalities. The proposed transmission model was based on a preexisting SEI-SIR model, but also incorporates the vector vertical transmission and the vector’s egg compartment, thus allowing rainfall to be introduced to modulate egg-hatching. Temperature and rainfall satellite data throughout the decade were used as climatic model inputs. A sensitivity analysis was performed to understand the role of each parameter. The model-simulated scenario was compared to the observed dengue incidence and the findings indicate that the model was able to capture the observed seasonal dengue incidence pattern with good accuracy until 2016, although higher deviations were observed from 2016 to 2019. The results further demonstrate that vertical transmission fluctuations can affect attack transmission rates and patterns, suggesting the need to investigate the contribution of vertical transmission to dengue transmission dynamics in future assessments. The improved understanding of the relationship between different environment variables and dengue transmission achieved by the proposed model can contribute to public health policies regarding mosquito-borne diseases.

scholarly journals Sequential Infection of Aedes aegypti Mosquitoes with Chikungunya Virus and Zika Virus Enhances Early Zika Virus Transmission

Insects ◽  
2018 ◽  
Vol 9 (4) ◽  
pp. 177 ◽  
Author(s):  
Tereza Magalhaes ◽  
Alexis Robison ◽  
Michael Young ◽  
William Black ◽  
Brian Foy ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Blood Meal ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Virus Transmission ◽  
Mosquito Vector ◽  
Molecular Aspects ◽  
Virus Interactions ◽  
Sequential Infection

In urban settings, chikungunya, Zika, and dengue viruses are transmitted by Aedes aegypti mosquitoes. Since these viruses co-circulate in several regions, coinfection in humans and vectors may occur, and human coinfections have been frequently reported. Yet, little is known about the molecular aspects of virus interactions within hosts and how they contribute to arbovirus transmission dynamics. We have previously shown that Aedes aegypti exposed to chikungunya and Zika viruses in the same blood meal can become coinfected and transmit both viruses simultaneously. However, mosquitoes may also become coinfected by multiple, sequential feeds on single infected hosts. Therefore, we tested whether sequential infection with chikungunya and Zika viruses impacts mosquito vector competence. We exposed Ae. aegypti mosquitoes first to one virus and 7 days later to the other virus and compared infection, dissemination, and transmission rates between sequentially and single infected groups. We found that coinfection rates were high after sequential exposure and that mosquitoes were able to co-transmit both viruses. Surprisingly, chikungunya virus coinfection enhanced Zika virus transmission 7 days after the second blood meal. Our data demonstrate heterologous arbovirus synergism within mosquitoes, by unknown mechanisms, leading to enhancement of transmission under certain conditions.

scholarly journals TRANSMISI TRANSOVARIAL VIRUS DENGUE PADA NYAMUKAEDES SPP.

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Angle M. H. Sorisi
Keyword(s):  
Dengue Virus ◽  
Vertical Transmission ◽  
Dengue Hemorrhagic Fever ◽  
Virus Transmission ◽  
Hemorrhagic Fever ◽  
Health Problems ◽  
Transovarial Transmission ◽  
Blood Sucking ◽  
Endemic Areas ◽  
And Control

Abstract: Dengue Hemorrhagic Fever (DHF) is one of the most serious health problems in Indonesia which often causes outbreaks with numerous deaths. The disease is transmitted byAedes sp.females. Generally, dengue virus transmission occurs horizontally from human carriers, and the dengue viruses are passed on bytheir vectors through blood sucking activity. After propagation in the mosquito, the viruses are transmitted to human recipients. In addition, there is a vertical transmission (transovarial) of dengue virusesin the ova of Aedes sp.females. The viruses propagate in the ova that undergo  metamorphosis to become larvae, pupae, and imagoes. The transovarial transmission of dengue virusesin its vectors in endemic areas could be a causative key which is responsible for the phenomenon of increasing cases of DHF. Any effort to prevent and control DHF requires a thorough understanding about virDen transmission, including this transovarial transmission in Aedes spfemales. Keywords: DHF, transovarial transmission, Aedes sp.     Abstrak: Penyakit Demam Berdarah Dengue (DBD) merupakan salah satu masalah kesehatan yang semakin serius di Indonesia dan sering menimbulkan suatu Kejadian Luar Biasa (KLB) dengan jumlah kematian tinggi. Penyakit ditularkan melalui Aedes sp.betina. Transmisi virus dengue umumnya terjadi secara horizontal, yaitu dari manusia pembawa virus dengue ke nyamuk vektor Aedes sp. melalui aktivitasnya mengisap darahSetelah mengalami propagasi  dalam  tubuh nyamuk, virus dengue ditularkan ke  manusia penerima. Selain itu, transmisi virus dapat terjadi secara vertikal (transovarial) yaitu virus dengue dalam tubuh nyamuk vektorAedes sp. betinake ovum, kemudian berpropagasi dalam ovum, larva, pupa, dan imago. Transmisi transovarial virus dengueke vektornya di daerah endemik bisa menjadi kunci penyebab yang bertanggung jawab terhadap fenomena peningkatan kasus deman berdarah dengue. Upaya pencegahan dan penanggulangan DBD memerlukan pengetahuan yang matang tentang adanya infeksi transovarial virDen pada nyamuk Aedes sp. Kata kunci : DBD, transmisi transovarial,  Aedes sp.

scholarly journals Chikungunya neonatal: A neglected disease

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Suyen Heizer Villela ◽  
◽  
Giuliana Villela Pereira ◽  
Maria Elisabeth Lopes Moreira ◽  
◽  
...  
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Clinical Assessment ◽  
Chikungunya Virus ◽  
Clinical Presentation ◽  
Case Series ◽  
Significant Morbidity ◽  
Case Series Report ◽  
Series Report

Chikungunya virus infection is an emerging arbovirus with a global distribution that can cause significant morbidity and also death in infected fetuses and neonates. Unfortunately, there is still lack of data about the incidence of Chikungunya in pregnant women and the consequences for their fetus. This is a case series report including clinical presentation, images and clinical assessment. Keywords: Chikungunya; neonatal; vertical transmission.

Late Identification of Chikungunya Virus in the Central Nervous System of a 2-Month-Old Infant: Persistence of Maternal-Neonatal Infection?

2019 ◽  
Vol 8 (4) ◽  
pp. 374-377
Author(s):  
Fátima C P A Di Maio Ferreira ◽  
Anamaria S V da Silva ◽  
Ana M Bispo de Filippis ◽  
Patrícia Brasil
Keyword(s):  
Vertical Transmission ◽  
Chikungunya Virus ◽  
Severe Infection ◽  
Neonatal Infection ◽  
Molecular Diagnostic ◽  
Cutaneous Lesions ◽  
Probable Case ◽  
The Central Nervous System ◽  
Polymerase Chain ◽  
Molecular Diagnostic Test

Abstract We report here a probable case of vertical transmission of chikungunya infection with confirmed maternal viremia close to labor that led to severe infection in the newborn. The newborn progressed with cutaneous lesions and irritability 2 months after vertical transmission, when chikungunya virus was detected in the infant’s CSF by a molecular diagnostic test (real-time polymerase chain reaction).

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