dynamics modelling
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2022 ◽  
Vol 14 (2) ◽  
pp. 862
Author(s):  
Miloš Jovičić ◽  
Goran B. Bošković ◽  
Nebojša Jovičić ◽  
Marija Savković ◽  
Ivan Mačužić ◽  
...  

This research develops a novel methodology for municipal waste management in Serbia, based on system dynamics modelling. The methodology shows how a country and relevant institutions should address complexities in the waste management sector. Waste management is a critical issue globally, which heavily impacts the economic development of a country, including the general quality of life within a society. The designed simulation generates different scenarios of the Serbian municipal waste system for reaching the 2035 recycling rate targets. Methodologies such as the theory of constraints, fragility analysis, and systems dynamics were implemented in the model. The scenarios and fragility modelling were conducted with the system dynamics modelling methodology in the Ventity simulation environment. The designed model has elements of discrete event simulations, system dynamics, and agent-based modelling. Importantly, real-world data for the period of five years (from the year 2016 to 2020) was used in the case study. This research undoubtedly reveals that the informal sector is the key source of fragility to the dynamic system considered. During the considered period, the informal sector contributed 62.3% of all separated waste to the system. Consequently, this research concludes that for the waste sector in Serbia to reach the 2035 EU goals, the existing practice in waste management has to be changed significantly and will benefit from the modelling approach used here. The whole system is highly dependent on the informal sector, which, in its current form, is volatile, unregulated, and fragile to aggressive regulative policies.


Author(s):  
Shibani ◽  
Julian Rajkumar ◽  
Vahid Aryai ◽  
Fatemeh Salehi ◽  
Rouzbeh Abbassi ◽  
...  

2022 ◽  
Vol 225 (1) ◽  
Author(s):  
Nicholas E. Durston ◽  
Yusuf Mahadik ◽  
Shane P. Windsor

ABSTRACT Estimating centre of mass and mass moments of inertia is an important aspect of many studies in biomechanics. Characterising these parameters accurately in three dimensions is challenging with traditional methods requiring dissection or suspension of cadavers. Here, we present a method to quantify the three-dimensional centre of mass and inertia tensor of birds of prey using calibrated computed tomography (CT) scans. The technique was validated using several independent methods, providing body segment mass estimates within approximately 1% of physical dissection measurements and moment of inertia measurements with a 0.993 R2 correlation with conventional trifilar pendulum measurements. Calibrated CT offers a relatively straightforward, non-destructive approach that yields highly detailed mass distribution data that can be used for three-dimensional dynamics modelling in biomechanics. Although demonstrated here with birds, this approach should work equally well with any animal or appendage capable of being CT scanned.


IEEE Access ◽  
2022 ◽  
pp. 1-1
Author(s):  
Brendan Michael ◽  
Akifumi Ise ◽  
Kaoru Kawabata ◽  
Takamitsu Matsubara

2021 ◽  
Vol 10 (6) ◽  
pp. 3766-3773
Author(s):  
Manish Kumar Gupta

The search for a prospective lead chemical is a time-consuming and complicated procedure that necessitates a lot of money, patience, and labour. Humans have been using phytochemicals, especially secondary metabolites, for this purpose since ancient times, and they are still on the hunt for even source for drug discovery. Natural flavonoids including rhamnetin, eupatorin, and primuletin are involved in the treatment of numerous biological diseases. The research focuses on molecular docking of 10 flavonoid compounds with the Interleukin-6 (1ALU) and TNF-α (5MU8) to assess the binding affinity at the binding location with the highest binding affinity. The flavonoid-protein complex with the highest binding affinity and interactions was studied using molecular dynamics modelling. With the Interleukin-6 (1ALU) and TNF-α (5MU8), the flavonoid naringin had the lowermost binding energy of 9.8 Kcal/mol. It took 20 nanoseconds to complete and yielded satisfactory results. The rhamnetin, eupatorin, and primuletin residues are more successful at maintaining flavonoid stability against Interleukin-6 (1ALU) and TNF-α (5MU8), according to the overall results of our simulation. These expected results will serve as a starting point for more investigation into the significance of their drug-likeliness properties in the management of ulcerative colitis.


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