Association of Body Mass Index with Semen Quality and Sexual Hormone Levels among Men in Intrauterine Insemination

The aim of this study was to recategorise body mass index (BMI) in order to classify patients according to their risk of semen abnormalities. Patients (n=20563) presenting at an andrology laboratory were classified into five groups according to BMI: underweight (BMI <20kg m−2), normal weight (BMI 20–24.9kg m−2), overweight (BMI 25–29.9kg m−2), obese (BMI 30–39.9kg m−2) and morbidly obese (BMI >40kg m−2). Semen quality was evaluated to determine: (1) differences between groups using analysis of variance (ANOVA); (2) the chances of semen abnormalities (using generalised linear models, Chi-squared tests and odds ratios); (3) reference BMI values with andrological predictive power (multivariate conglomerate analyses and multivariate analysis of variance (MANOVA)); and (4) expected values of abnormalities for each new group resulting from BMI recategorisation. Morbidly obese and underweight patients exhibited the highest decrease in semen quality and had higher chances of semen abnormalities. The smallest number of sperm abnormalities was found at a BMI of 27kg m−2. Four reference values were identified, recategorising BMI into four groups according to their risk of semen abnormalities (from lowest to highest risk): Group1,BMI between 20 and 32kg m−2; Group2, BMI <20 and BMI >32–37kg m−2; Group3, BMI >37–42kg m−2; and Group4, BMI >42kg m−2. A BMI <20 or >32kg m−2 is negatively associated with semen quality; these negative associations on semen quality increase from a BMI >37kg m−2 and increase even further for BMI >42kg m−2. The BMI recategorisation in this study has andrological predictive power.

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Adjusting antimüllerian hormone levels for age and body mass index improves detection of polycystic ovary syndrome

Fertility and Sterility ◽

10.1016/j.fertnstert.2019.12.012 ◽

2020 ◽

Vol 113 (4) ◽

pp. 876-884.e2

Author(s):

Glenn E. Palomaki ◽

Bhanu Kalra ◽

Tanya Kumar ◽

Amita S. Patel ◽

Gopal Savjani ◽

...

Keyword(s):

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Hormone Levels ◽

Antimullerian Hormone ◽

Antimüllerian Hormone

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Effect of sex-hormone levels, sex, body mass index and other host factors on human craniofacial bone regeneration with bioactive tricalcium phosphate grafts

Biomaterials ◽

10.1016/j.biomaterials.2017.01.035 ◽

2017 ◽

Vol 123 ◽

pp. 48-62 ◽

Cited By ~ 5

Author(s):

Christine Knabe ◽

Aynur Mele ◽

Peter Herbert Kann ◽

Barbara Peleska ◽

Doaa Adel-Khattab ◽

...

Keyword(s):

Body Mass Index ◽

Bone Regeneration ◽

Body Mass ◽

Tricalcium Phosphate ◽

Sex Hormone ◽

Host Factors ◽

Hormone Levels ◽

Craniofacial Bone

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Body mass index, waist-to-hip ratio, waist circumference and waist-to-height ratio cannot predict male semen quality: a report of 1231 subfertile Chinese men

Andrologia ◽

10.1111/and.12376 ◽

2014 ◽

Vol 47 (9) ◽

pp. 1047-1054 ◽

Cited By ~ 17

Author(s):

J.-C. Lu ◽

J. Jing ◽

J.-Y. Dai ◽

A. Z. Zhao ◽

Q. Yao ◽

...

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Body Mass ◽

Semen Quality ◽

Height Ratio ◽

Waist To Hip Ratio ◽

Chinese Men ◽

Waist To Height Ratio

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423 ASSOCIATIONS BETWEEN SEMEN QUALITY, BODY MASS INDEX AND METABOLIC SYNDROME PARAMETERS IN YOUNG MALE

European Urology Supplements ◽

10.1016/s1569-9056(10)60420-4 ◽

2010 ◽

Vol 9 (2) ◽

pp. 154 ◽

Cited By ~ 2

Author(s):

K. Ausmees ◽

M. Zarkovski ◽

G. Timberg ◽

P. Korrovits ◽

M. Punab

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Body Mass ◽

Semen Quality ◽

Young Male

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The relationship between body mass index and anti-mullerian hormone levels in reproductive-age women; is there a negative correlation?

Fertility and Sterility ◽

10.1016/j.fertnstert.2018.02.083 ◽

2018 ◽

Vol 109 (3) ◽

pp. e42-e43 ◽

Cited By ~ 1

Author(s):

Monica C. Pasternak ◽

Paul Christos ◽

Steven D. Spandorfer

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Negative Correlation ◽

Reproductive Age ◽

Hormone Levels ◽

Reproductive Age Women ◽

The Relationship

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Hormone Imbalance in Women with Infertility Caused by Polycystic Ovary Syndrome: Is There a Connection with Body Mass Index?

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2020.4569 ◽

2020 ◽

Vol 8 (B) ◽

pp. 731-737

Author(s):

Mariya Khmil ◽

Stephan Khmil ◽

Mariya Marushchak

Keyword(s):

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Reproductive Hormones ◽

The Body ◽

Control Group ◽

Ovary Syndrome ◽

Hormone Levels ◽

Hormonal Imbalance

BACKGROUND: The most common cause of female infertility is ovulation disorders, and the most common non-ovulatory cause is polycystic ovary syndrome (PCOS). AIM: The aim of the study was to define the reproductive hormone levels in women with infertility due to PCOS, depending on the body mass index (BMI). PATIENTS AND METHODS: The present study involved 100 women aged 25–39 years with infertility due to PCOS (PCOS group) and 30 women of the same age with infertility due to tubal-peritoneal causes (control group). Infertility due to PCOS was diagnosed according to the Rotterdam criteria. Hormone levels (anti-Müllerian [AMH], follicle-stimulating [FSH], luteinizing [LH], prolactin, estradiol, and testosterone) in blood serum were determined by ELISA. RESULTS: We detected a correlation between BMI and sex hormone levels as well as LH/FSH ratio. Notably, the ratio of LH/FSH in women with PCOS was significantly different compared to the control group, while at the same time, PCOS was significantly more frequent in overweight and obese patients compared to those with normal BMI. For instance, the LH/FSH ratio was 30.35% higher in women with Class 2 obesity than in the group of women with normal weight. However, in women with both PCOS and Class 3 obesity, the LH/FSH ratio was the lowest among those with a BMI of 25.0-39.9. CONCLUSIONS: We found a hormonal imbalance in women with infertility caused by PCOS: Increased levels of AMH and LH, estradiol, and testosterone and decreased FSH levels. Analysis of the relationship between the concentration of reproductive hormones and BMI showed a weak inverse relationship between BMI with FSH levels, as well as a direct correlation with the levels of LH, prolactin, estradiol, and testosterone, and LH/FSH ratio. Thus, obesity exacerbates the hormonal imbalance in women with infertility caused by PCOS.

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