Prevalence of Hypertension and Associated Factors in Patients Living with HIV Followed at the Ambulatory Treatment Center (CTA) of Fann National University Hospital in Dakar

In Congo, the distribution of generic drugs including ARVs (Antiretrovirals) is done through dispensing sites. This paper focuses on describing the management, delivery, and supply of ARVs at two sites in Brazzaville, and thus contributes to improving the management of HIVpositive patients. This is a cross-sectional, observational, descriptive, and analytical study of 3,473 patients registered at the Hospital and University Hospital Pharmacy (CHUB) and Ambulatory Treatment Center (CTA) during the period from 1st January to December 31, 2010. The data were collected using medical records, prescriptions, inventory sheets, purchase orders, delivery notes of the Congolaise of Essential Medicines Generic (COMEG), and informal interview with the heads of dispensing units. Of the 3473 patients registered, there were 1412 men (40.65%) and 2061 women (59.34%). A sex ratio of 0.68 at the pharmacy of CHUB 13427 boxes of ARVs was ordered unlike the CTA where this number was 30810 boxes of ARV. The COMEG delivered to the CTA 28,667 boxes of ARVs (93.04%) dispensing 18,994 boxes. Half of the ARVs dispensed were the triple combinations (56,48%). At the CHUB pharmacy, COMEG delivered 15,371 boxes of ARVs, of which 28.16% is also a triple therapy. The analysis of the system revealed a poor estimate of needs because the dispensing and management of these drugs does not conform to the active queue.

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Prevalence and Associated Factors to Cryptococcosis in the Infectious Diseases Department of the National University Hospital Center of Fann in Dakar (Senegal)

Microbiology & Infectious Diseases ◽

10.33425/2639-9458.1035 ◽

2018 ◽

Vol 2 (3) ◽

Author(s):

Ossibi Ibara BR ◽

Manga NM ◽

Daye Ka ◽

Dieng Yemou ◽

NDour Tidiane CHEIK ◽

...

Keyword(s):

Infectious Diseases ◽

Associated Factors ◽

University Hospital ◽

National University ◽

Hospital Center

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Staging accuracy of endoscopic ultrasonography in esophageal cancer, Jae Hoon Cheong, Pusan National University Hospital

Endoscopy ◽

10.1055/s-0031-1292097 ◽

2011 ◽

Vol 43 (S 03) ◽

Author(s):

Ryu Dong Yup

Keyword(s):

Esophageal Cancer ◽

Endoscopic Ultrasonography ◽

University Hospital ◽

Staging Accuracy ◽

National University

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Intestinal parasite survey of Kyungpook National University Hospital patients

The Korean Journal of Parasitology ◽

10.3347/kjp.1971.9.2.47 ◽

1971 ◽

Vol 9 (2) ◽

pp. 47 ◽

Cited By ~ 11

Author(s):

Dong Wik Choi ◽

Sung Deok Park ◽

Jae Woun Kim ◽

Doo Hong Ahn ◽

Young Myung Kim

Keyword(s):

Intestinal Parasite ◽

University Hospital ◽

Hospital Patients ◽

National University

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Circulating regulatory T cells predict efficacy and atypical responses in lung cancer patients treated with PD-1/PD-L1 inhibitors

Cancer Immunology Immunotherapy ◽

10.1007/s00262-021-03018-y ◽

2021 ◽

Author(s):

Da Hyun Kang ◽

Chaeuk Chung ◽

Pureum Sun ◽

Da Hye Lee ◽

Song-I Lee ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Advanced Nsclc ◽

Checkpoint Inhibitors ◽

Standard Of Care ◽

Treg Cells ◽

University Hospital ◽

X Rays ◽

Lung Cancer Patients ◽

National University

Abstract Background Immune checkpoint inhibitors (ICIs) have become the standard of care for a variety of cancers, including non-small cell lung cancer (NSCLC). In this study, we investigated the frequency of pseudoprogression and hyperprogression in lung cancer patients treated with ICIs in the real world and aimed to discover a novel candidate marker to distinguish pseudoprogression from hyperprogression soon after ICI treatment. Methods This study included 74 patients with advanced NSCLC who were treated with PD-1/PD-L1 inhibitors at Chungnam National University Hospital (CNUH) between January 2018 and August 2020. Chest X-rays were examined on day 7 after the first ICI dose to identify changes in the primary mass, and the response was assessed by computed tomography (CT). We evaluated circulating regulatory T (Treg) cells using flow cytometry and correlated the findings with clinical outcomes. Results The incidence of pseudoprogression was 13.5%, and that of hyperprogression was 8.1%. On day 7 after initiation of treatment, the frequency of CD4+CD25+CD127loFoxP3+ Treg cells was significantly decreased compared with baseline (P = 0.038) in patients who experienced pseudoprogression and significantly increased compared with baseline (P = 0.024) in patients who experienced hyperprogression. In the responder group, the frequencies of CD4+CD25+CD127loFoxP3+ Treg cells and PD-1+CD4+CD25+CD127loFoxP3+ Treg cells were significantly decreased 7 days after commencement of treatment compared with baseline (P = 0.034 and P < 0.001, respectively). Conclusion Circulating Treg cells represent a promising potential dynamic biomarker to predict efficacy and differentiate atypical responses, including pseudoprogression and hyperprogression, after immunotherapy in patients with NSCLC.

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Prevalence of pain in women living with HIV aged 45–60: associated factors and impact on patient-reported outcomes

AIDS Care ◽

10.1080/09540121.2021.1887445 ◽

2021 ◽

pp. 1-10

Author(s):

Caroline A. Sabin ◽

Hajra Okhai ◽

Rageshri Dhairyawan ◽

Katharina Haag ◽

Fiona Burns ◽

...

Keyword(s):

Associated Factors ◽

Patient Reported Outcomes ◽

Women Living With Hiv ◽

Patient Reported ◽

Prevalence Of Pain ◽

Living With Hiv

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Definition of a novel vaccination pathway in PLWHA: experience of a Southern University Hospital

European Journal of Public Health ◽

10.1093/eurpub/ckaa166.837 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

S D'Amato ◽

G F Pellicanò ◽

C Genovese ◽

F Mazzitelli ◽

G Nunnari ◽

...

Keyword(s):

Infectious Diseases ◽

Vaccination Coverage ◽

Clinical Pathway ◽

Drop Out ◽

University Hospital ◽

Treatment Center ◽

People Living With Hiv ◽

Vaccination Rates ◽

Operating Unit ◽

Hiv Aids

Abstract Background At the end of 2018 across the globe there are ∼37.9 million people with HIV/AIDS also thanks to the use of HAART which led to an increase in life expectancy. The Italy Immunization Plan 2017-19 recommend vaccines to these patients but a protocol still isn't present. Moreover, despite the availability of effective vaccines, coverage remained very low for many reasons including problems with privacy. The objectives of this study were a) the appliance of a shared clinical pathway between the “Immunization Center of Hospital Hygiene Operating Unit” and the “HIV/AIDS Disease Prevention, Diagnosis and Treatment Center of Infectious Diseases Operating Unit” b) the increase in vaccination coverage and the evaluation of side effects. Methods A prospective study was conducted from Oct 2019 to Feb 2020 at the G. Martino University Hospital of Messina. In particular, of the 138 patients followed by the Infectious Diseases OU, after evaluation of their immune status, 62% were enrolled in this study. Following the acquisition of informed consent, we collected socio-anagraphical data and we started the free administration of vaccines by providing an hoc calendar in the Immunization Center. Statistical analysis was performed with R software. Results The sample was represented by 86 patients (74% males and 26% females, 21% foreigners and 79% Italian, mean age=40±13.6 SD). We didn't observe drop out and no differences were observed for local/systemic AEs generally reported. We obtained an increase of vaccination coverage with a total of 74 doses administered for flu (+164%) and 240 for other vaccines (+172%). In particular, we immunized a total of 74% of patients for HPV (2% in 2018), 42% for HAV (28% in 2018), 37% for HBV (28% in 2018), 58% for pneumococcal (21% in 2018), 54% for meningococcal ACWY and B (0% in 2018). Conclusions The undertook clinical pathway showed the relevance of specific management of these patients and the need to increase the vaccination offer. Key messages The immunization in people living with HIV is priority to reduce the risk of infectious disease. It’s important to implement a shared clinical pathway to increase vaccination rates of these patients. The application of the protocol had an high impact in patients' adhesion to vaccination also thanks to the chance of accessing to the service in a comfortable setting and suitable to protect privacy.

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Association of Carotid Artery Endothelial Signal Intensity Gradient with Unilateral Large Artery Ischemic Stroke

Cerebrovascular Diseases ◽

10.1159/000514141 ◽

2021 ◽

Vol 50 (3) ◽

pp. 270-278

Author(s):

Chan-Hyuk Lee ◽

Sang Hyuk Lee ◽

Young I. Cho ◽

Seul-Ki Jeong

Keyword(s):

Ischemic Stroke ◽

Carotid Artery ◽

Signal Intensity ◽

Internal Carotid ◽

University Hospital ◽

Large Artery ◽

Intensity Gradient ◽

National University ◽

Endothelial Shear Stress ◽

Stroke Center

Background: Common carotid artery (CCA) and internal carotid artery (ICA) are aligned linearly, but their hemodynamic role in ischemic stroke has not been studied in depth. Objectives: We aimed to investigate whether CCA and ICA endothelial shear stress (ESS) could be associated with the ischemic stroke of large artery atherosclerosis (LAA). Methods: We enrolled consecutive patients with unilateral ischemic stroke of LAA and healthy controls aged >60 years in the stroke center of Jeonbuk National University Hospital. All patients and controls were examined with carotid artery time-of-flight magnetic resonance angiography, and their endothelial signal intensity gradients (SIGs) were determined, as a measure of ESS. The effect of right or left unilateral stroke on the association between carotid artery endothelial SIG and ischemic stroke of LAA was assessed. Results: In total, the results from 132 patients with ischemic stroke of LAA and 121 controls were analyzed. ICA endothelial SIG showed significant and independent associations with the same-sided unilateral ischemic stroke of LAA, even after adjusting for the potential confounders including carotid stenosis, whereas CCA endothelial SIG showed a significant association with the presence of the ischemic stroke of LAA. Conclusion: Although CCA and ICA are located with continuity, the hemodynamics and their roles in large artery ischemic stroke should be considered separately. Further studies are needed to delineate the pathophysiologic roles of ESS in CCA and ICA for large artery ischemic stroke.

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