scholarly journals Definition of a novel vaccination pathway in PLWHA: experience of a Southern University Hospital

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S D'Amato ◽  
G F Pellicanò ◽  
C Genovese ◽  
F Mazzitelli ◽  
G Nunnari ◽  
...  

Abstract Background At the end of 2018 across the globe there are ∼37.9 million people with HIV/AIDS also thanks to the use of HAART which led to an increase in life expectancy. The Italy Immunization Plan 2017-19 recommend vaccines to these patients but a protocol still isn't present. Moreover, despite the availability of effective vaccines, coverage remained very low for many reasons including problems with privacy. The objectives of this study were a) the appliance of a shared clinical pathway between the “Immunization Center of Hospital Hygiene Operating Unit” and the “HIV/AIDS Disease Prevention, Diagnosis and Treatment Center of Infectious Diseases Operating Unit” b) the increase in vaccination coverage and the evaluation of side effects. Methods A prospective study was conducted from Oct 2019 to Feb 2020 at the G. Martino University Hospital of Messina. In particular, of the 138 patients followed by the Infectious Diseases OU, after evaluation of their immune status, 62% were enrolled in this study. Following the acquisition of informed consent, we collected socio-anagraphical data and we started the free administration of vaccines by providing an hoc calendar in the Immunization Center. Statistical analysis was performed with R software. Results The sample was represented by 86 patients (74% males and 26% females, 21% foreigners and 79% Italian, mean age=40±13.6 SD). We didn't observe drop out and no differences were observed for local/systemic AEs generally reported. We obtained an increase of vaccination coverage with a total of 74 doses administered for flu (+164%) and 240 for other vaccines (+172%). In particular, we immunized a total of 74% of patients for HPV (2% in 2018), 42% for HAV (28% in 2018), 37% for HBV (28% in 2018), 58% for pneumococcal (21% in 2018), 54% for meningococcal ACWY and B (0% in 2018). Conclusions The undertook clinical pathway showed the relevance of specific management of these patients and the need to increase the vaccination offer. Key messages The immunization in people living with HIV is priority to reduce the risk of infectious disease. It’s important to implement a shared clinical pathway to increase vaccination rates of these patients. The application of the protocol had an high impact in patients' adhesion to vaccination also thanks to the chance of accessing to the service in a comfortable setting and suitable to protect privacy.

2019 ◽  
Vol 09 (04) ◽  
pp. 141-157
Author(s):  
Abdou Razak Moukaila ◽  
Lidaw Déassoua Bawe ◽  
Edem Komi Mossi ◽  
Akessiwe Akouda Patassi ◽  
Yawovi Mawufemo Tsevi ◽  
...  

2017 ◽  
Vol 70 (2) ◽  
pp. 392-399 ◽  
Author(s):  
Clarissa Mourão Pinho ◽  
Bruno Felipe Remigio Dâmaso ◽  
Eduardo Tavares Gomes ◽  
Maria de Fátima Cordeiro Trajano ◽  
Maria Sandra Andrade ◽  
...  

ABSTRACT Objective: evaluate the religiosity and the religious/spiritual coping of people living with HIV/Aids. Method: descriptive, cross-sectional study with quantitative approach, conducted in a reference HIV/Aids outpatient clinic in a university hospital of Recife-PE, Brazil, from June to November 2015. At total of 52 people living with HIV/Aids (PLWHA) participated in the research, which employed own questionnaire, the Duke University Religion Index (DUREL), and the Religious/Spiritual Coping Scale (RCOPE). Results: the sample presented high indices of organizational religiosity (4.23±1.66), non-organizational religiosity (4.63±1.50), and intrinsic religiosity (13.13±2.84). Positive RCOPE was used in high mean scores (3.66±0.88), and negative RCOPE had low use (2.12 ± 0.74). In total, use of RCOPE was high (3.77±0.74), having predominated the positive RCOPE (NegRCOPE/PosRCOPE ratio=0.65±0.46). Conclusion: it is evident the importance of encouraging religious activity and RCOPE strategies, seen in the past as inappropriate interventions in clinical practice.


10.3823/2633 ◽  
2021 ◽  
Vol 14 ◽  
Author(s):  
Fatima Maria da Silva Abrão ◽  
Verônica Mirelle Alves Oliveira Pereira ◽  
Regina Célia de Oliveira ◽  
Carlos Roberto Lyra da Silva ◽  
Amanda Regina da Silva Góis

Background: since its discovery as the etiological agent of the Acquired Immune Deficiency Syndrome (AIDS), the Human Immunodeficiency Virus (HIV) has infected 75.7 million people worldwide Due to the specific characteristics of the Brazilian population, it is considered that spirituality, or spiritual well-being, is an important factor in the way individuals face the HIV/AIDS problematic and its consequences. To understand the spirituality of living with HIV in the light of Neuman's Systems Model. Method: qualitative, descriptive-exploratory research in the light of the Systems Model proposed by Betty Neuman. Data collection took place between the months of March and August 2016 in an outpatient clinic specialized in the treatment of patients with HIV/AIDS of a university hospital located in the city of Recife, Pernambuco, Brazil. Thirty people living with HIV participated in the study. The data were collected through a questionnaire and an interview with a semi-structured script and underwent categorical content analysis. Results: the understanding of spirituality in living with HIV is presented in three categories: the discovery of the diagnosis and the initial reactions: stressors that affect the lines of defense; the spiritual and religious search: protection when stressors penetrate the lines of defense; and the influence of faith combined with ART in living with HIV: dynamic relationship of the variable spirituality with the other variables. Conclusion: the applicability of the theory can provide important gains to the patient living with HIV/AIDS, generating a way to ensure the strengthening and establishment of lines of defense during their daily lives, and thus maintaining the balance of the patient's system, as well as the harmonic relationship between its variables and the environment.


2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S132-S133
Author(s):  
Deborah A Kahal ◽  
Christopher James ◽  
Brian Wharton ◽  
Sherine Eaddy ◽  
Elizabeth Gaines ◽  
...  

Abstract Background Seasonal influenza vaccination decreases individual and population-level morbidity and mortality, mitigates risk of acquiring influenza-like illness, and prevents healthcare system overburdening. Vaccination is important for people living with HIV (PLWH) who have increased risk for severe disease, hospitalization, and poor outcomes. Moreover, influenza vaccination has been associated with decreased COVID-19 mortality in older patients. Historical annual adult influenza vaccinations rates at the study site were 65%, exceeding local and national benchmarks. Amidst COVID-19, we recognized a need to increase influenza vaccination rates. Methods A multifaceted, bundled quality improvement (QI) initiative aimed to achieve ≥ 80% influenza vaccination coverage for the 2020-21 season in PLWH ≥18 years of age at our Wilmington site (N=750). Stakeholders were identified, and a voluntary multidisciplinary team formed to lead the initiative (Fig. 1). Fishbone diagram outlined clear, rapidly implementable, and reproducible levers for change (Fig. 2). Physical and virtual space changes included: diverse clinical displays (visuals, patient materials), phone messaging, and virtual platform use. Staff education and updates were consistently provided by the team. Institutional Review Board exemption was received, and electronic medical record and CareWare data were extracted from 1 Oct 2020 through 31 March 2021. All external vaccinations were confirmed. Overall and eligible in-clinic vaccination rates were updated and displayed weekly. Results 86% vaccination coverage was achieved (Fig. 3) with a median weekly in-clinic vaccination rate of 67% (Fig. 4). Conclusion A QI project to improve 2020-21 influenza vaccination rates exceeded our goal in adult PLWH at an urban mid-Atlantic HIV clinic during the COVID-19 pandemic. A multidisciplinary approach that engaged stakeholders was vital to success. Rapid roll-out of changes was challenging, requiring flexibility and clear communication. Data collection was consistent, albeit imperfect, and needs enhancement. Elucidating the effects of each change and the COVID-19 pandemic on vaccination rates is not yet known. Lessons learned may be applicable to other ambulatory settings and will inform future vaccination efforts. Disclosures Deborah A. Kahal, MD,MPH, FACP, Gilead (Speaker’s Bureau)Viiv (Speaker’s Bureau)


Folia Medica ◽  
2017 ◽  
Vol 59 (4) ◽  
pp. 454-460 ◽  
Author(s):  
Mariyana V. Stoycheva ◽  
Nikolay T. Vatev ◽  
Vania B. Georgieva ◽  
Antonina P. Dineva ◽  
Maria V. Atanasova ◽  
...  

AbstractBackground: The introduction of complex antiretroviral therapy has resulted in signifi cant decrease in the mortality rate of HIV positive patients, but it still remains unacceptably high, especially in some groups of patients. Aim: To investigate the death rate in patients with HIV/AIDS, lethality and mortality in co-infection, and the most common causes and predictors of fatal outcome, focused on early diagnosis and appropriate therapy. Materials and methods: The study included 53 deceased patients with HIV/AIDS, monitored at the Clinic of Infectious Diseases in St George University Hospital, Plovdiv between 01.01.2010 and 31.12.2014. The methods of research included clinical analysis, laboratory tests, microbiological and serological tests (HCV, HBV, toxoplasmosis), ELISA, PCR. Statistical analysis was performed by descriptive statistics, the Student’s t-test, the method of Van der Ward, and regression analysis (logistic regression). Results: During the study period 316 patients with HIV/AIDS were monitored, 53 of them with lethal outcome. Lethality was 16.7% for the whole group; in intravenous drug users - 13.8%; in co-infected patients: HIV/M. tuberculosis - 46%, in HIV/HCV - 17.8%. Lethality and mortality in HIV(+) patients with co-infections in populations of diff erent age, gender, duration since starting сАRТ and degree of immunodefi ciency (according to CD4, VL) was compared with the lethality and mortality in patients with these conditions from the general population. Conclusions: Fatal outcome in patients with HIV/AIDS was most commonly associated with co-infections HIV/M. tuberculosis and HIV/HCV. Predictors of a fatal outcome are pulmonary tuberculosis, advanced immunodefi ciency with VL> 500 000 c/μL and CD4 <100/mm3, absence or non-systemic antiretroviral therapy.


2021 ◽  
Vol 54 (1) ◽  
pp. e168968
Author(s):  
Bruno Augusto Aguilar ◽  
André Pereira dos Santos ◽  
Dalmo Roberto Lopes Machado ◽  
Euripedes Bardanulfo Gonçalves Gomide ◽  
Emerson Sebastião ◽  
...  

Aims: To identify the frequency in changes of bone metabolism, including below the average value for age, osteopenia, and osteoporosis, in people living with HIV/AIDS (PLWHA) and to compare the frequency of factors associated with bone mineral density (BMD) and body composition between sex. Methods: This observational study assessed 106 PLWHA (65 male) recruited from the University Hospital of Ribeirão Preto Medical School from 2013 to 2014. BMD was measured using Dual Energy X-ray Absorptiometry (DXA). Standard deviation values for Z- and T-score proposed by the International Society for Clinical Densitometry were adopted to classify participants below the average value for age, osteopenia, and osteoporosis. Qui-square and Fischer’s exact tests were employed to compare males and females based on their factors associated with BMD reduction. Results: Fifty-two (49%) PLWHA presented at least one diagnosis for below the average value for age, osteopenia, and osteoporosis, being 37 (57%) and 15 (37%) male and female, respectively. Frequency of alcohol consumption was higher in males (n=20; 30.8%) than females (n=05; 12.2%) (p=0.028). Conclusions: A high rate of PLWHA showed changes in bone metabolism, with a higher frequency in males. The frequency of alcohol consumption was higher in males, and it may partially explain the possible causes of the increased rates of bone metabolism changes observed in this group. This information may help develop strategies for reducing the frequency of diagnosis for below the average value for age, osteopenia, osteoporosis improving quality of life in PLWHA.


Sign in / Sign up

Export Citation Format

Share Document