scholarly journals Expression of B Locus Beta 2 (<i>BLB2</i>) Gene at Cytolytic and Latent Immune Response Stages of Immunocompetence in Nigerian Indigenous Chickens

2021 ◽  
Vol 11 (02) ◽  
pp. 164-174
Author(s):  
Abdulraheem Adedeji Bello-Ibiyemi ◽  
Adeyemi Sunday Adenaike ◽  
Micheal Irewole Takeet ◽  
Akpan Ubong ◽  
Christian Obiora Ndubuisi Ikeobi
Keyword(s):  
Immune Response ◽  
B Locus ◽  
Indigenous Chickens ◽  
Beta 2

scholarly journals Neonatal treatment with low doses of anti-idiotypic antibody leads to the expression of a silent clone.

1981 ◽  
Vol 153 (4) ◽  
pp. 1004-1008 ◽  
Author(s):  
J Hiernaux ◽  
C Bona ◽  
P J Baker
Keyword(s):  
Immune Response ◽  
Low Doses ◽  
Newborn Mice ◽  
Myeloma Protein ◽  
Neonatal Treatment ◽  
Beta 2 ◽  
Idiotypic Antibody

BALB/c mice immunized with bacterial levan (BL) produce an immune response that fails to generate antibody expressing the idiotype (Id) of the beta (2 leads to 6) fructosan-binding myeloma protein ABPC 48 (A48). Pretreatment of newborn BALB/c mice (at 1 d of age) with 0.01-10 microgram of affinity purified BALB/c anti-A48 Id antibody followed by immunization with BL 1-2 mo later produces an anti-BL response that expresses the A48 Id. This shows that A48 Id+ anti-BL clones belong to a normally silent fraction of the anti-BL repertoire. The activation of A48 Id+ anti-BL clones anti-A48 Id antibody is specific because the pretreatment of newborn mice with anti-MOPC 384 Id antibody, followed by immunization with BL, does not lead to its activation. Moreover, pretreatment of mice with anti-A48 Id antibody does not alter the MOPC 460 Id+ component of the anti-TNP response. It is also important to note that the activation of the A48 Id+ clone in pretreated mice requires subsequent immunization with BL.

scholarly journals Immune response kinetics in Nigerian indigenous chickens challenged with attenuated Salmonella

2020 ◽  
Vol 47 (2) ◽  
pp. 57-67
Author(s):  
M. A. Opoola ◽  
A. S. Adenaike ◽  
O. A. Jegede ◽  
N. I Akutubuola ◽  
A. J. Fajemisin ◽  
...  
Keyword(s):  
Immune Response ◽  
Red Blood Cells ◽  
Cell Volume ◽  
Antibody Titre ◽  
Packed Cell Volume ◽  
Blood Cells ◽  
Haemoglobin Concentration ◽  
High Titre ◽  
Naked Neck ◽  
Indigenous Chickens

Salmonella infection is a major cause of death in chickens and this disease can be transferred through meat and egg to humans. The use of antibiotics and vaccines in the prevention and control of this infection are not totally efficient and also have their side effects. Therefore, genetic control is a better approach in finding a lasting solution. One hundred and ten chickens (4th generation) comprising the three genotypes of Nigerian indigenous chickens(NIC) that had shown divergent response (high vs low) to sheep red blood cells antigens were used in this study to investigate the immune response kinetics in NIC after challenged with attenuated Salmonella. There were six classes namely, high titre normal, low titre normal, high titre frizzle, low titre frizzle, high titre naked neck and low titre naked neck. Haematological parameters: packed cell volume (PCV), haemoglobin concentration (Hb),red blood cells count (RBC), white blood cells count (WBC), heterophils (H), lymphocytes (L), eosinophils (E), basophils (B), monocytes (M) and heterophils-lymphocytes ratio (HLR) were used to assess the immune responses of the chickens and data collected were subjected to General Linear Model procedure of SAS 9.2 version. The results showed that genotypeantibody titre had significant effect (p<0.05) on the immune response parameters but sex had no significant effect (p>0.05), while sex by genotype-antibody titre interaction had significant effect (p<0.05). The immune response kinetics of the chickens after challenge with attenuated Salmonella was shown by the significance of the effect of days of blood collection after challenge. High titre naked neck chickens recorded the highest PCV, Hb and RBC values while genotype-antibody titre had no significant effect (p>0.05) on the rest of the parameters. Low titre naked neck males recorded the highest PCV, HB and RBC values while the rest of the parameters were not significant (p>0.05). Generally, days had significant effect (p<0.05) on all the immune response parameters except on H, L and HLR. The study showed that the high titre naked neck males were least affected by the Salmonella vaccine in terms of decrease in packed cell volume, haemoglobin concentration and red blood cell count while the low titre normal females were most affected.

scholarly journals Idiotype-antiidiotype regulation. V. The requirement for immunization with antigen or monoclonal antiidiotypic antibodies for the activation of beta 2 leads to 6 and beta 2 leads to 1 polyfructosan-reactive clones in BALB/c mice treated at birth with minute amounts of anti-A48 idiotype antibodies.

1983 ◽  
Vol 158 (4) ◽  
pp. 1129-1144 ◽  
Author(s):  
L J Rubinstein ◽  
B Goldberg ◽  
J Hiernaux ◽  
K E Stein ◽  
C A Bona
Keyword(s):  
Monoclonal Antibody ◽  
Immune Response ◽  
Direct Interaction ◽  
Single Strain ◽  
Immunoglobulin Receptor ◽  
Monoclonal Protein ◽  
Antiidiotypic Antibodies ◽  
Beta 2 ◽  
Old Mice ◽  
Antibody Secreting Cells

The anti-beta 2 leads to 6 fructosan antibodies sharing the idiotypes (Id) of ABPC48 (A48) monoclonal protein represent a silent fraction of the anti-beta 2 leads to 6 fructosan repertoire, since these antibodies cannot be detected during a conventional immune response elicited by bacterial levan (BL). However, the administration at birth of minute amounts of anti-A48 Id antibodies causes a long-lasting activation of A48 Id+-bearing clones. This activation is related to direct interaction of anti-A48 Id antibodies with precursors bearing the A48 Id+ immunoglobulin receptor, since an A48 Id+ response can be transferred with highly purified B cells in lethally irradiated mice. The maturation of these precursors into A48 Id+ anti-beta 2 leads to 6 fructosan antibody-secreting cells requires challenge by the antigen. Isoelectric focusing (IEF) data showed that in 1-mo-old mice an UPC10 (U10)-like spectrotype was observed, whereas in 3-mo-old mice, a new spectrotype binding BL rather than inulin (In) was identified. This spectrotype was observed only in CXBJ mice, the single strain in which an A48 Id+ response was observed. The antigenic challenge can be replaced by a monoclonal anti-A48 Id antibody (i.e., 17-38). Interestingly, in 1-mo-old BALB/c mice treated with anti-A48 Id antibodies, the challenge with 17-38 monoclonal antibody led to the activation of A48 Id- anti-beta 2 leads to 6 fructosan-reactive clones with BALB/c type IEF spectrotypes, whereas in 3-mo-old BALB/c mice treated with anti-A48 Id antibodies, the challenge with 17-38 monoclonal antibody led to the activation of W3082 IdX+ anti-beta 2 leads to 6 and beta 2 leads to 1 fructosan-reactive clones. In these animals, inhibition of A48 Id+ anti-beta 2 leads to 6 fructosan clones was observed. This antibody probably represents a homobody carrying the internal image of the antigen, which through its paratope suppresses the A48 Id+ response and through its Id activates an A48 Id- anti-beta 2 leads to 6 fructosan response in 1-mo-old mice and in 3-mo-old mice leads to an anti-beta 2 leads to 6 and beta 2 leads to 1 fructosan response dominated by the W3082 IdX.(ABSTRACT TRUNCATED AT 400 WORDS)

Immune Response and Adult Mortality Associated with the B Locus in Chickens

1977 ◽  
pp. 245-256 ◽  
Author(s):  
A. W. Nordskog ◽  
I. Y. Pevzner ◽  
C. L. Trowbridge ◽  
A. A. Benedict
Keyword(s):  
Immune Response ◽  
Adult Mortality ◽  
B Locus
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