scholarly journals Effects of three controlled mechanical ventilation modes on rat lung hydrogen peroxide and apoptosis during hemorrhagic shock

2013 ◽  
Vol 03 (01) ◽  
pp. 27-35
Author(s):  
Amanda R. Thimmesch ◽  
Qiuhua Shen ◽  
Richard L. Clancy ◽  
Janet D. Pierce
Keyword(s):  
Hydrogen Peroxide ◽  
Mechanical Ventilation ◽  
Hemorrhagic Shock ◽  
Rat Lung ◽  
Ventilation Modes ◽  
Controlled Mechanical Ventilation

Prolonged Respiratory Insufficiency and Ventilator Dependence in the ICU

2014 ◽  
Author(s):  
Gaëtan Beduneau ◽  
Jean-Christophe M Richard ◽  
Laurent Brochard
Keyword(s):  
Mechanical Ventilation ◽  
Spontaneous Breathing ◽  
Prolonged Mechanical Ventilation ◽  
Early Mobilization ◽  
Economic Cost ◽  
Psychological Status ◽  
Difficult Weaning ◽  
Ventilation Modes ◽  
Controlled Mechanical Ventilation ◽  
Prolonged Immobilization

The process of separation or weaning from mechanical ventilation can be arbitrarily separated into three categories: (1) simple weaning when patients are separated from the ventilator after the first attempt of unsupported spontaneous breathing. This usually represents slightly more than half of the patients; (2) difficult weaning when up to three attempts or 1 week is necessary to successfully separate the patient from the ventilator; (3) prolonged weaning for the remaining patients. This last group represents between 6 and 20% of the ICU population arriving at the stage of weaning and carries a considerable human and economic cost. A global approach, including measures to optimize psychological status, nutritional support, and sleep, is essential in the management of these patients, and referral to specialized weaning centres may be helpful. Muscle weakness is a very frequent finding in patients undergoing prolonged mechanical ventilation and may be worsened by excessive sedation, prolonged immobilization, and the use of controlled mechanical ventilation modes. It follows that approaches that include sedation sparing, early mobilization, and the transition to spontaneous breathing are likely to be beneficial.

scholarly journals Transcriptome profiling of the diaphragm in a controlled mechanical ventilation model reveals key genes involved in ventilator-induced diaphragmatic dysfunction

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ruining Liu ◽  
Gang Li ◽  
Haoli Ma ◽  
Xianlong Zhou ◽  
Pengcheng Wang ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Signaling Pathway ◽  
Wistar Rats ◽  
Cholesterol Metabolism ◽  
Expression Profiles ◽  
Receptor Interaction ◽  
Pathophysiological Mechanism ◽  
Rna Seq ◽  
Diaphragmatic Dysfunction ◽  
Controlled Mechanical Ventilation

Abstract Background Ventilator-induced diaphragmatic dysfunction (VIDD) is associated with weaning difficulties, intensive care unit hospitalization (ICU), infant mortality, and poor long-term clinical outcomes. The expression patterns of long noncoding RNAs (lncRNAs) and mRNAs in the diaphragm in a rat controlled mechanical ventilation (CMV) model, however, remain to be investigated. Results The diaphragms of five male Wistar rats in a CMV group and five control Wistar rats were used to explore lncRNA and mRNA expression profiles by RNA-sequencing (RNA-seq). Muscle force measurements and immunofluorescence (IF) staining were used to verify the successful establishment of the CMV model. A total of 906 differentially expressed (DE) lncRNAs and 2,139 DE mRNAs were found in the CMV group. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to determine the biological functions or pathways of these DE mRNAs. Our results revealed that these DE mRNAs were related mainly related to complement and coagulation cascades, the PPAR signaling pathway, cholesterol metabolism, cytokine-cytokine receptor interaction, and the AMPK signaling pathway. Some DE lncRNAs and DE mRNAs determined by RNA-seq were validated by quantitative real-time polymerase chain reaction (qRT-PCR), which exhibited trends similar to those observed by RNA-sEq. Co-expression network analysis indicated that three selected muscle atrophy-related mRNAs (Myog, Trim63, and Fbxo32) were coexpressed with relatively newly discovered DE lncRNAs. Conclusions This study provides a novel perspective on the molecular mechanism of DE lncRNAs and mRNAs in a CMV model, and indicates that the inflammatory signaling pathway and lipid metabolism may play important roles in the pathophysiological mechanism and progression of VIDD.

scholarly journals Patient-Ventilator Synchrony and Tidal Volume Variability using NAVA and Pressure Support Mechanical Ventilation Modes

2011 ◽  
Vol 44 (1) ◽  
pp. 569-574
Author(s):  
Katherine T. Moorhead ◽  
Lise Piquilloud ◽  
Bernard Lambermont ◽  
Jean Roeseler ◽  
J. Geoffrey Chase ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Tidal Volume ◽  
Pressure Support ◽  
Ventilation Modes ◽  
Ventilator Synchrony

Alternative Modes of Mechanical Ventilation

2018 ◽  
Vol 29 (4) ◽  
pp. 396-404
Author(s):  
John J. Gallagher
Keyword(s):  
Mechanical Ventilation ◽  
Closed Loop ◽  
Treatment Options ◽  
Ventilatory Support ◽  
Dual Control ◽  
Mechanical Ventilators ◽  
Lung Protection ◽  
Ventilation Modes ◽  
Volume Controlled ◽  
Pressure Controlled

Modern mechanical ventilators are more complex than those first developed in the 1950s. Newer ventilation modes can be difficult to understand and implement clinically, although they provide more treatment options than traditional modes. These newer modes, which can be considered alternative or nontraditional, generally are classified as either volume controlled or pressure controlled. Dual-control modes incorporate qualities of pressure-controlled and volume-controlled modes. Some ventilation modes provide variable ventilatory support depending on patient effort and may be classified as closed-loop ventilation modes. Alternative modes of ventilation are tools for lung protection, alveolar recruitment, and ventilator liberation. Understanding the function and application of these alternative modes prior to implementation is essential and is most beneficial for the patient.

Pressure-controlled ventilation versus controlled mechanical ventilation with decelerating inspiratory flow

1993 ◽  
Vol 21 (8) ◽  
pp. 1143-1148 ◽  
Author(s):  
JAVIER MUÑOZ ◽  
JOSE EUGENIO GUERRERO ◽  
JOSE LUIS ESCALANTE ◽  
RICARDO PALOMINO ◽  
BRAULIO DE LA CALLE
Keyword(s):  
Mechanical Ventilation ◽  
Inspiratory Flow ◽  
Controlled Ventilation ◽  
Pressure Controlled Ventilation ◽  
Controlled Mechanical Ventilation ◽  
Pressure Controlled

Controversial Aspects of PEEP Ventilation in Emergency Medicine

1987 ◽  
Vol 3 (2) ◽  
pp. 21-27 ◽  
Author(s):  
W. Dick ◽  
I. Schutz
Keyword(s):  
Emergency Medicine ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Clinical Treatment ◽  
Positive End Expiratory Pressure ◽  
Early Application ◽  
Therapeutic Measure ◽  
Controlled Mechanical Ventilation ◽  
Pulmonary Changes ◽  
Peep Ventilation

Controlled mechanical ventilation using positive and expiratory pressure (PEEP) is a well-established therapeutic measure in intensive care. Its early application has been shown to markedly decrease morbidity and mortality, especially in polytraumatized patients with an acute respiratory distresss syndrome. It therefore seems reasonable to use positive end expiratory pressure as early as possible in the clinical treatment of emergency patients before extensive pulmonary changes have had time to develop completely.

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