Comparative Study between Intraoperative Frozen Section and Scrape Smear Cytology in the Diagnosis of Ovarian Neoplasm

Objectives: To present three cases of young women with suspected ovarian malignancy with the aim to evaluate the role of intraoperative frozen section in suspected malignant ovarian neoplasms in women with young age.Case Report: Mrs. M, 25 years old, is a nullipara with a history of fertility treatment. She presented with bilateral ovarian cysts suspected to be malignant and an elevated CA-125 level. Intraoperative frozen section showed borderline ovarian tumor, allowing for conservative management. Mrs. A, 32-years old, with right cystic ovarian neoplasm suspected to be malignant and elevated CA-125. Frozen section showed results of cystadenocarcinoma, patient’s family was informed of the result during the surgery and the operator continued to manage the patient conservatively. Ms. N, 27 years old, was referred with suspected ovarian malignancy and the differential diagnosis of peritoneal tuberculosis. Frozen section confirmed the presence of tuberculosis infection, and the patient was managed accordingly.Conclusion: Despite conservative management being top priority treatment in young-aged women with ovarian neoplasm, additional information of frozen section allows for more accurate management.

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A comparative study of intraoperative frozen section and alpha defensin lateral flow test in the diagnosis of periprosthetic joint infection

Acta Orthopaedica ◽

10.1080/17453674.2019.1567153 ◽

2019 ◽

Vol 90 (2) ◽

pp. 105-110 ◽

Cited By ~ 4

Author(s):

Irene K Sigmund ◽

Johannes Holinka ◽

Susanna Lang ◽

Sandra Stenicka ◽

Kevin Staats ◽

...

Keyword(s):

Comparative Study ◽

Periprosthetic Joint Infection ◽

Frozen Section ◽

Joint Infection ◽

Lateral Flow ◽

Intraoperative Frozen Section ◽

Flow Test ◽

Lateral Flow Test

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Diagnostic accuracy of intraoperative frozen section in ovarian neoplasms: Experience in a tertiary oncology centre

10.1055/s-0039-1685293 ◽

2016 ◽

Author(s):

Anu Bajracharya ◽

Rupinder Sekhon ◽

Shweta Giri ◽

Sudhir Rawal

Keyword(s):

Diagnostic Accuracy ◽

Malignant Tumors ◽

Frozen Section ◽

Ovarian Neoplasm ◽

Predictive Values ◽

Intraoperative Frozen Section ◽

The Mean ◽

Oncology Centre ◽

Line Of Therapy ◽

Sensitivity Specificity

Aims and Objectives: This study is done to assess the accuracy of intraoperative frozen section in the diagnosis of various categories of ovarian neoplasm conducted in RGCI. Materials and Methods: Introperative frozen sections for suspected ovarian neoplasm that underwent surgery as primary line of therapy at this institution were analyzed retrospectively from Jan. 2014 - Dec. 2015. The results of frozen section were compared with the final histopathologic diagnosis on paraffin sections and the overall accuracy, sensitivity, specificity, positive and negative predictive values were determined. Results: The study included 159 cases and the mean age of patients was 44.72 ± 14.28 years (Range 19-75 years). The mean size of tumor was 12.5 ± 5.9 cm. Sensitivity of frozen section for benign, borderline and malignant tumors was 98.53%, 73.33% and 94.74% respectively. And the related specificities were 95.60%, 96.53% and 100% respectively. There were 150 concordant cases and 9 discordant cases. Overall diagnostic accuracy of frozen section was 94.33%. Conclusion: Intraoperative frozen section diagnosis appears to be an accurate and comparable technique for the histopathology diagnosis of ovarian tumours. It is a valuable tool to guide the surgical management of these patients.

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Accuracy of Intraoperative Frozen Section in Diagnosing Malignancy of Ovarian Neoplasm

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v3i3.47 ◽

2016 ◽

Author(s):

Tofan W Utami ◽

Jasmine Iskandar ◽

Gregorius Tanamas ◽

Mona Jamtani ◽

Laila Nuranna ◽

...

Keyword(s):

Medical Records ◽

Obstet Gynecol ◽

Ovarian Neoplasms ◽

Frozen Section ◽

Ovarian Neoplasm ◽

Exclusion Criteria ◽

Intraoperative Frozen Section ◽

Paraffin Block ◽

Histopathological Type ◽

Block Sensitivity

Objective: To evaluate the accuracy of frozen section for ovarian neoplasm in our hospital. Method: A retrospective evaluation was conducted on medical records of patients with ovarian neoplasms who underwent a frozen section laparotomy between the years 2008 and 2013 at Dr. Cipto Mangunkusumo Hospital. Records with incomplete data on frozen section or paraffin block report were excluded. Criteria for frozen section laparotomy in our facility was based on a malignancy score of equal to or more than 6. Frozen section reports were compared to paraffin block report based on benign, borderline, or malignant cases. Result: From 139 patients with ovarian neoplasm, only 91 patients fulfilled the inclusion and exclusion criteria. Frozen section examination revealed benign cases was 15.4%, borderline cases was 15.4%, and malignant cases was 69.2%. Based on histopathological type, clear cell cystoadenocarcinoma was the most commonly observed histotype (19.8%). The sensitivity of frozen section for benign, borderline, and malignancy cases respectively was 81.8%, 76.9%, 91.0%. The specificity of frozen section for benign, borderline, and malignancy case respectively was 93.8%, 94.8%, 91.6%. Conclusion: We found that the accuracy of intraoperative frozen section in our facility is adequate to diagnose ovarian neoplasm and can be used to assist in determining the extent of surgical management. [Indones J Obstet Gynecol 2015; 3: 161-164] Keywords: frozen section, ovarian neoplasm, paraffin block, sensitivity, specitificity

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RESEARCH ON VALUE OF INTRAOPERATIVE FROZEN SECTION EXAMINATION OF THE COMMON TUMORS AT HUE UNIVERSITY HOSPITAL

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2011.6.8 ◽

2011 ◽

pp. 67-73

Author(s):

Cong Thuan Dang ◽

Thi Thu Thao Le

Keyword(s):

Sensitivity And Specificity ◽

Frozen Section ◽

Analysis Data ◽

Poor Quality ◽

University Hospital ◽

Frozen Sections ◽

Intraoperative Frozen Section ◽

Frozen Section Examination ◽

Incorrect Diagnosis ◽

The Common

Background: To evaluate the accuracy and the pitfalls of frozen section examination in diagnosis the common tumors at Hue University Hospital. Materials and method: A retrospective analysis data of 99 consecutive patients from 2007 to 2009 were evaluated and analyzed the major pitfalls. In our 99 patients, 100% cases we compared histological diagnosis on frozen sections with those on paraffin sections. Results: The majority of frozen section examinations were the thyroid lesions 37.4%, breast lesions 25.2%, lymph nodes 16.1%, ovary 9.1% and less common in other diseases (12.1%). The accuracy, sensitivity and specificity of the intraoperative frozen section examination were 93.9%, 89.1% and 98.1% respectively. The main factors causing incorrect diagnosis in frozen section are: Misinterpretation, poor quality of frozen sections, improper sampling in sectioning and difficult to result interpretation. Conclusion: The frozen section analysis of suspect lesions displays good sensitivity and specificity characteristics.

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