scholarly journals 11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease

2012 ◽  
Vol 11 (3) ◽  
pp. 3122-3132 ◽  
Author(s):  
F. Atalar ◽  
B. Vural ◽  
C. Ciftci ◽  
A. Demirkan ◽  
G. Akan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Metabolic Syndrome ◽  
Coronary Artery ◽  
Hydroxysteroid Dehydrogenase ◽  
Ascending Aorta ◽  
Artery Disease

scholarly journals NETosis in Long-Term Type 1 Diabetes Mellitus and Its Link to Coronary Artery Disease

2022 ◽  
Vol 12 ◽  
Author(s):  
Sverre Grøver Aukrust ◽  
Kristine Bech Holte ◽  
Trine B. Opstad ◽  
Ingebjørg Seljeflot ◽  
Tore Julsrud Berg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Artery Disease

BackgroundNeutrophil extracellular traps NETs have been linked to glucose and the pathogenesis of type 1 diabetes mellitus (T1DM). NETs also play a role in vascular inflammation and the development of coronary artery disease (CAD). The role of NETs in CAD progression in patients with long-term T1DM is unclear. We aimed to 1) investigate whether levels of circulating NETs markers were elevated in long-term T1DM subjects compared to controls, and 2) explore whether levels of NETs were related to the presence of CAD.Material and Methods102 patients with > 45 years of T1DM and 75 age-matched controls were enrolled in a cross-sectional study. Median age was 62 years. Computed tomography coronary angiography (CTCA) was performed in 148 subjects without established coronary heart disease. For the current study, CAD was defined as a coronary artery stenosis >50%. Double-stranded deoxyribonucleic acid (dsDNA) was measured by a nucleic acid stain, myeloperoxidase-DNA (MPO-DNA), citrullinated histone 3 (H3Cit) and peptidylarginine deiminase 4 (PAD4) by ELISAs, while gene expression of PAD4 was measured in leukocytes from PAXgene tubes.ResultsCirculating MPO-DNA levels were significantly lower in patients with T1DM than in controls (0.17 vs 0.29 OD, p<0.001), while dsDNA, H3Cit, PAD4 and gene expression of PAD4 did not differ with respect to the presence of T1DM. There were no significant associations between NETs markers and HbA1c in the T1DM group. None of the NETs markers differed according to the presence of CAD in patients with T1DM. While all circulating NETs markers correlated significantly with circulating neutrophils in the control group (r=0.292-393, p<0.014), only H3Cit and PAD4 correlated with neutrophils in the T1DM group (r= 0.330-0.449, p ≤ 0.001).ConclusionsIn this cross-sectional study of patients with long-term T1DM and age-matched controls, circulating NETs levels were not consistently associated with the presence of T1DM or glycemic status, and did not differ according to the presence of CAD in patients with T1DM. Our results entail the possibility of altered neutrophil function and reduced NETosis in T1DM. This warrants further investigation.

Predictive Utilities of Blood Pressure Variables on Coronary Artery Disease in Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 161-OR
Author(s):  
JINGCHUAN GUO ◽  
TREVOR J. ORCHARD
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Artery Disease

1931-P: Skeletal Muscle (SM) Insulin Resistance (IR) in Coronary Artery Disease (CAD) in Type 1 Diabetes (T1D)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1931-P
Author(s):  
KATHERINE V. WILLIAMS ◽  
CHRISTINA M. SHAY ◽  
JULIE PRICE ◽  
TREVOR J. ORCHARD ◽  
DAVID KELLEY
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Artery Disease
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