scholarly journals Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression

2013 ◽  
Vol 12 (2) ◽  
pp. 1907-1915 ◽  
Author(s):  
H. He ◽  
J. Chen ◽  
W.P. Xie ◽  
S. Cao ◽  
H.Y. Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Side Effect ◽  
Human Breast Cancer ◽  
Undesirable Side Effect ◽  
Human Breast ◽  
Breast Cancer Therapy ◽  
Apoptosis Protein

scholarly journals Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy

2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Breast Cancer Therapy

scholarly journals The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Ying Liu ◽  
Wei Cao ◽  
Bo Zhang ◽  
Yong-qiang Liu ◽  
Zhong-yuan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Human Breast Cancer ◽  
Natural Compound ◽  
Human Breast ◽  
Breast Cancer Therapy

Furanodiene alters mitochondrial function in doxorubicin-resistant MCF-7 human breast cancer cells in an AMPK-dependent manner

2016 ◽  
Vol 12 (5) ◽  
pp. 1626-1637 ◽  
Author(s):  
Zhang-Feng Zhong ◽  
Wen Tan ◽  
William W. Qiang ◽  
Virginia L. Scofield ◽  
Ke Tian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Medicine ◽  
Cancer Therapy ◽  
Traditional Chinese Medicine ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Dependent Manner ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Furanodiene is a bioactive sesquiterpene isolated from the spice-producing Curcuma wenyujin plant (Y. H. Chen and C. Ling) (C. wenyujin), which is a commonly prescribed herb used in clinical cancer therapy by modern practitioners of traditional Chinese medicine.

scholarly journals PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Andrä Brunner ◽  
Aldwin Suryo Rahmanto ◽  
Henrik Johansson ◽  
Marcela Franco ◽  
Johanna Viiliäinen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cancer Therapy ◽  
Human Breast Cancer ◽  
Transcriptome Profiling ◽  
Human Breast ◽  
Replication Checkpoint ◽  
Replication Arrest ◽  
Highly Sensitive ◽  
Wee1 Kinase

Inhibition of WEE1 kinase by AZD1775 has shown promising results in clinical cancer trials, but markers predicting AZD1775 response are lacking. Here we analysed AZD1775 response in a panel of human breast cancer (BC) cell lines by global proteome/transcriptome profiling and identified two groups of basal-like BC (BLBCs): ‘PTEN low’ BLBCs were highly sensitive to AZD1775 and failed to recover following removal of AZD1775, while ‘PTEN high’ BLBCs recovered. AZD1775 induced phosphorylation of DNA-PK, protecting cells from replication-associated DNA damage and promoting cellular recovery. Deletion of DNA-PK or PTEN, or inhibition of DNA-PK sensitized recovering BLBCs to AZD1775 by abrogating replication arrest, allowing replication despite DNA damage. This was linked to reduced CHK1 activation, increased cyclin E levels and apoptosis. In conclusion, we identified PTEN and DNA-PK as essential regulators of replication checkpoint arrest in response to AZD1775 and defined PTEN as a promising biomarker for efficient WEE1 cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document