Association between chemical composition of essential oil with penetration enhancement effect and drug properties of traditional Chinese medicine

2016 ◽  
Keyword(s):  
Chemical Composition ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Essential Oil ◽  
Enhancement Effect ◽  
Penetration Enhancement

Comparision of Bupleurum scorzoneri folium Willd. Grouping from Different Habitats Based on Pattern Recognition with R Software

2011 ◽  
Vol 393-395 ◽  
pp. 1139-1142
Author(s):  
Wen Rui ◽  
Hong Yuan Chen ◽  
Yi Fan Feng ◽  
Zhong Feng Shi ◽  
Miao Miao Jiang
Keyword(s):  
Pattern Recognition ◽  
Chemical Composition ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Hierarchical Clustering ◽  
Chemical Data ◽  
R Software ◽  
Pattern Recognition Methods

Bupleurum scorzoneri folium Willd.(BSFW) is a traditional Chinese medicine which is widely distributed in China. To evaluate the quality of BSFW from different habitats, samples from 5 different areas in China were determined by UPLC/MS. The chemical data were dealed with hierarchical clustering, PCA, SPCA, PLSDA and SPLSDA using R software. The results show that these pattern recognition methods can fully reflect the chemical composition of different areas of BSFW, which make it possible to control the quality.

scholarly journals Impact of Microwave Treatment on Chemical Constituents in Fresh Rhizoma Gastrodiae (Tianma) by UPLC-MS Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-10
Author(s):  
Qimeng Fan ◽  
Chaoyin Chen ◽  
Dingqi Xie ◽  
Shenglan Zhao
Keyword(s):  
Chemical Composition ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chemical Constituents ◽  
Microwave Treatment ◽  
Microwave Oven ◽  
Chemical Component ◽  
Vanillyl Alcohol ◽  
Microwave Technology ◽  
Active Compounds

Fresh Rhizoma Gastrodiae (Tianma) was processed in a microwave oven at 2450 MHz in order to study the effect on the main chemical component changes taking place during microwave treatment. It was found that microwave affected the chemical composition of Tianma. Seven compounds, including gastrodin, gastrodigenin (p-hydroxybenzylalcohol), p-hydroxybenzaldehyde, vanillyl alcohol, vanillin, adenine, and 5-hydroxymethylfurfural, were identified in this study. As major active compounds, the contents of gastrodin and gastrodigenin in MWT Tianma were both twice as much as those in raw Tianma. Besides, the MS data show that there are still some unidentified compositions in Tianma, and there are also many converted compounds in MWT Tianma, which is worthy of further work. The results have indicated that microwave treated fresh Tianma might be helpful in designing the processing of traditional Chinese medicine and the application of microwave technology in traditional Chinese medicine needs to be researched further in the future.

scholarly journals Phenolics in the Tussilago farfara leaves

2013 ◽  
Vol 59 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Justyna Chanaj-Kaczmarek ◽  
Małgorzata Wojcińska ◽  
Irena Matławska
Keyword(s):  
Chemical Composition ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Literature Review ◽  
Respiratory Tract Diseases ◽  
Nmr Analysis ◽  
Flower Buds ◽  
Quercetin Derivatives ◽  
Tussilago Farfara ◽  
C Nmr

Summary Coltsfoot leaves (Farfarae folium) are used in the European medicine in respiratory tract diseases, for cough, bronchitis and asthmatic disorders, while in the traditional Chinese medicine only flower buds (Farfarae flos) have been recognized as a medicine. A short literature review shows that most data concern the chemical composition of the coltsfoot flowers. During the carried out studies we have isolated and identified (UV, 1H and 13C NMR, analysis of acid and enzymatic hydrolyze products) six known flavonols from the coltsfoot leaves: kaempferol and its 3-O-β-glucopyranoside and 3-O-α-rhamnopyranosyl(1→6)- β-glucopyranoside, along with quercetin derivatives: 3-O-β-arabinopyranoside, 3-O-β- glucopyranoside and 3-O-α-rhamnopyranosyl(1→6)-β-glucopyranoside. Moreover, we have detected the presence of three phenolic acids.

scholarly journals The Correlation between Chemical Composition, as Determined by UPLC-TOF-MS, and Acute Toxicity ofVeratrum nigrumL. andRadix paeoniae alba

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Xianxie Zhang ◽  
Yuguang Wang ◽  
Qiande Liang ◽  
Zengchun Ma ◽  
Chengrong Xiao ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Acute Toxicity ◽  
Chemical Constituents ◽  
Two Agents ◽  
Veratrum Alkaloids ◽  
Radix Paeoniae Alba ◽  
Insight Into ◽  
Tof Ms

The eighteen incompatible medicaments is an important theory in traditional Chinese medicine. The theory suggests that drugs in the eighteen incompatible medicaments can be toxic when used together.Veratrum nigrumL. andRadix paeoniae albabelong to the eighteen incompatible medicaments and have been prohibited for thousands of years. This study offers preliminary insight into the mechanism and chemical constituents responsible for the incompatibility and toxicity of these two agents. Specifically, we performed toxicology studies to identify and quantify the constituent substances of the two agents. Experiments revealed that acute toxicity increases when the dose ofV. nigrumL. is higher than, or equal to, RPA. UPLC-TOF-MS analysis showed that, although the volumes ofV. nigrumL. were the same, the content of some veratrum alkaloids changed significantly and had a trend toward a highly positive correlationr≥0.8with toxicity. This suggests that the increased toxicity of theV. nigrumL. and RPA combination was due mainly to increased content of the special veratrum alkaloids. The cytotoxicity of veratridine in SH-SY5Y cells was decreased with increasing paeoniflorin concentrations. This study provides insight into the mechanism behind the incompatibility theory of TCM.

scholarly journals Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 170 ◽  
Author(s):  
Jifen Zhang ◽  
Jiao Zhang ◽  
Shuai Wang ◽  
Tao Yi
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Essential Oil ◽  
Oral Bioavailability ◽  
Pickering Emulsion ◽  
Oral Drug ◽  
Volatile Oils ◽  
Ligusticum Chuanxiong ◽  
Emulsion Droplets ◽  
Poorly Soluble

In this study, an oral drug nanocrystals self-stabilized Pickering emulsion (NSSPE), which used nanocrystals of a poorly soluble ingredient from Puerariae Radix called puerarin as solid particle stabilizers and Ligusticum chuanxiong essential oil since the main oil phase had been developed to improve the oral bioavailability of puerarin. The appearance of emulsions, size and zeta potential of droplets, and content of puerarin in emulsified layer during a storage of six months at 4, 25, and 40 °C were investigated. The centrifugation stability at 4000× g was also studied. The micro-structure of emulsion droplets was characterized by a scanning electron micrograph (SEM), confocal laser scanning microscopy (CLSM), a fluorescence microscope (FM), and differential scanning calorimetry (DSC). The in vivo oral bioavailability of puerarin NSSPE was investigated in rats. Results showed that appearances of puerarin NSSPE kept stable after centrifugation at 4000× g for 15 min or storage for six months at 4, 25, and 40 °C. SEM, CLSM, FM, and DSC showed that the puerarin NSSPE had a stable core-shell structure of emulsion droplets formed by the adsorption of puerarin nanocrystals on the surface of oil droplets of mixed oil of Ligusticum chuanxiong essential oil and Labrafil M 1944 CS (9:1, v/v). The relative bioavailability of puerarin NSSPE to puerarin coarse powder suspension, nanocrystal suspension, and surfactant emulsion were 262.43%, 155.92%, and 223.65%, respectively. All these results indicated that puerarin nanocrystals could stabilize Pickering emulsion of Ligusticum chuanxiong essential oil without any other stabilizers and Pickering emulsion could improve the oral bioavailability of puerarin, which suggests that the drug nanocrystal self-stabilized Pickering emulsion as a promising oral drug delivery system for Traditional Chinese Medicine containing poorly soluble ingredients and volatile oils.

The essential oil from the raw and vinegar processed Rhizoma Curcumae ameliorate CCl4-incuded liver fibrosis: integrating network pharmacology and molecular mechanism evaluation

2021 ◽  
Author(s):  
Yi Chen ◽  
Wan Liao Wan Liao ◽  
Zongping Zhu ◽  
Jiao Chen ◽  
Qing Song Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Fibrosis ◽  
Liver Cancer ◽  
Essential Oil ◽  
Molecular Mechanism ◽  
Chronic Liver ◽  
Network Pharmacology ◽  
Liver Injuries ◽  
Rhizoma Curcumae

Liver fibrosis caused by multiple chronic liver injuries, is a known contributor to cirrhosis, and even liver cancer. Rhizoma Curcumae as a Traditional Chinese Medicine (TCM) has been extensively used...

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