Inflammatory mediators in dengue virus infection in children: interleukin-6 and its relation to C-reactive protein and secretory phospholipase A2.

2001 ◽  
Vol 65 (1) ◽  
pp. 70-75 ◽  
Author(s):  
M Juffrie ◽  
A J Veerman ◽  
K Haasnoot ◽  
G M Meer ◽  
L G Thijs ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Phospholipase A2 ◽  
Inflammatory Mediators ◽  
Interleukin 6 ◽  
Secretory Phospholipase A2 ◽  
C Reactive Protein ◽  
Dengue Virus Infection ◽  
Secretory Phospholipase ◽  
Reactive Protein

Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome

Blood ◽  
2005 ◽  
Vol 105 (8) ◽  
pp. 3384-3385 ◽  
Author(s):  
Emilee M. Bargoma ◽  
Joyce K. Mitsuyoshi ◽  
Sandra K. Larkin ◽  
Lori A. Styles ◽  
Frans A. Kuypers ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Phospholipase A2 ◽  
Sickle Cell ◽  
Acute Chest Syndrome ◽  
Secretory Phospholipase A2 ◽  
Cell Disease ◽  
C Reactive Protein ◽  
Secretory Phospholipase ◽  
Reactive Protein

scholarly journals Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital

2017 ◽  
Vol 12 (3) ◽  
pp. 187
Author(s):  
Bashir Abdrhman Bashir Mohamed
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Teaching Hospital ◽  
Hepatic Dysfunction ◽  
Dengue Infection ◽  
Moderate Increase ◽  
C Reactive Protein ◽  
Dengue Virus Infection ◽  
Cross Sectional ◽  
Reactive Protein

Background Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective This study aimed to evaluate the hepatic effect of dengue fever amongst Sudanese patients.Materials and Methods A cross-sectional descriptive study recruited in Port Sudan teaching hospital in the period from February 2013 to June 2014.  334 cases of dengue along with 101 cases of control were enrolled. Rapid immune chromatographic test was used to confirm positive dengue cases and WHO criteria were used for classifying the dengue severity. Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen level (FB), platelet count (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) were all measured. Results PT, PTT, and FB were found to be significantly higher in the infected cohort when compared to the controls (P< 0.0001). PT was prolonged in 9%, PTT was prolonged in 12.6% and shortened by 5.4% of the patients, whereas hypofibrinogenemia in 18.3% and hyperfibrinogenemia in 67.4% of the patients. Bleeding was seen in 10.5% of patients and thrombocytopenia was detected in 83.5% of patients. Out of 334 patients, 101 (30.2%) had abnormal coagulation results. Of 101 patients, 72 were subjected mixing studies for PT and PTT that revealed deficiencies in factors VIII (35%), IX (10%), V (10%), X (19%), and XII (14%). 43.6% patients had elevated AST and 21.8% had elevated ALT.ConclusionThis study demonstrated that hepatic dysfunction may be attributed to dengue virus infection which evident by prolongation in PT and PTT as well as hypofibrinogenemia and factor deficiencies.    

scholarly journals A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells

1997 ◽  
Vol 18 (3) ◽  
pp. 111-115 ◽  
Author(s):  
C.Erik Hack ◽  
Gert-Jan Wolbink ◽  
Caspar Schalkwijk ◽  
Han Speijer ◽  
Willem Th. Hermens ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
C Reactive Protein ◽  
Secretory Phospholipase ◽  
Reactive Protein

scholarly journals Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

2018 ◽  
Vol 31 (0) ◽  
Author(s):  
Barbara Gazolla de Macedo ◽  
Hanna Sette Câmara de Oliveira ◽  
Marielle Viotti de Paula ◽  
Gisele de Cássia Gomes ◽  
Carlos Maurício de Figueiredo Antunes
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Functional Capacity ◽  
Inflammatory Mediators ◽  
Interleukin 6 ◽  
The Elderly ◽  
Community Dwelling ◽  
Elderly Subjects ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: To assess the association between inflammatory mediators, interleukin 6 (IL-6) and C-reactive protein (CRP) and functional capacity in the elderly. Methods: Cross-sectional study with 308 community-dwelling elderly. The study was approved by the Research Ethics Committee, under protocol number 067/2010. Grip strength (GS) was measured using a JAMAR® dynamometer and functional capacity by the Timed Up and Go (TUG) test. Blood tests were performed and serum levels of C-reactive protein and interleukin 6 assessed. Spearman’s coefficient was applied to analyze the correlation between variables and the Mann-Whitney for intergroup comparison. Significance was set at 0.05. Results: There was no significant correlation between GS, the TUG and inflammatory mediators (CRP and IL-6). However, by adjusting for variables such as age, sex and muscle mass, a significant and inverse correlation (p = 0.023) was observed between GS and CPR. Conclusion: Elderly subjects with low C-reactive protein levels performed better in the grip strength test. It is important to investigate the adverse effects on functional capacity that can be influenced by inflammatory cytokines in the elderly during aging.

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