scholarly journals Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital

2017 ◽  
Vol 12 (3) ◽  
pp. 187
Author(s):  
Bashir Abdrhman Bashir Mohamed
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Teaching Hospital ◽  
Hepatic Dysfunction ◽  
Dengue Infection ◽  
Moderate Increase ◽  
C Reactive Protein ◽  
Dengue Virus Infection ◽  
Cross Sectional ◽  
Reactive Protein

Background Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective This study aimed to evaluate the hepatic effect of dengue fever amongst Sudanese patients.Materials and Methods A cross-sectional descriptive study recruited in Port Sudan teaching hospital in the period from February 2013 to June 2014.  334 cases of dengue along with 101 cases of control were enrolled. Rapid immune chromatographic test was used to confirm positive dengue cases and WHO criteria were used for classifying the dengue severity. Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen level (FB), platelet count (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) were all measured. Results PT, PTT, and FB were found to be significantly higher in the infected cohort when compared to the controls (P< 0.0001). PT was prolonged in 9%, PTT was prolonged in 12.6% and shortened by 5.4% of the patients, whereas hypofibrinogenemia in 18.3% and hyperfibrinogenemia in 67.4% of the patients. Bleeding was seen in 10.5% of patients and thrombocytopenia was detected in 83.5% of patients. Out of 334 patients, 101 (30.2%) had abnormal coagulation results. Of 101 patients, 72 were subjected mixing studies for PT and PTT that revealed deficiencies in factors VIII (35%), IX (10%), V (10%), X (19%), and XII (14%). 43.6% patients had elevated AST and 21.8% had elevated ALT.ConclusionThis study demonstrated that hepatic dysfunction may be attributed to dengue virus infection which evident by prolongation in PT and PTT as well as hypofibrinogenemia and factor deficiencies.    

scholarly journals KADAR HEMOGLOBIN DAN UJI TOURNIQUET PADA PASIEN ANAK DENGAN INFEKSI VIRUS DENGUE DI MANADO

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Joseph Hardi ◽  
Glady Rambert ◽  
Firginia Manoppo
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Pediatric Patients ◽  
Total Population ◽  
Dengue Infection ◽  
Population Sample ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Dengue Virus Infection ◽  
Cross Sectional

Abstract: Dengue infection is a systemic and dynamic disease that has a broad spectrum. The key for good management and results is to know and understand arising signs. Various examination is necessary for diagnosis, one of them are the examination of hemoglobin levels and tourniquet test. This research was a cross sectional study. Samples were obtained from 37 pediatric patients with dengue virus infection of the total population sample of 72 patients in RS Advent Manado, RSU GMIM Pancaran Kasih Manado, and RSAD Robert Wolter Mongisidi Teling. The results of this study show the hemoglobin levels on pediatric patients with dengue virus infection mostly in normal levels and not all patients show positive tourniquet test results.Keywords: dengue, hemoglobin levels, tourniquet testAbstrak: Infeksi dengue adalah suatu penyakit sistemik dan dinamik yang memiliki spektrum yang luas. Kunci keberhasilan dalam pengelolaan dan hasil yang baik adalah mengenal dan memahami tanda-tanda yang timbul. Diperlukan berbagai pemeriksaan penunjang salah satu diantaranya adalah pemeriksaan kadar hemoglobin dan uji tourniquet. Penelitian ini merupakan penelitian cross sectional. Sampel penelitian diperoleh 37 pasien anak dengan infeksi virus dengue dari total populasi sampel 72 pasien di RS Advent Manado, RSU GMIM Pancaran Kasih Manado, dan RSAD Robert Wolter Mongisidi Teling. Hasil penelitian menunjukkan gambaran hemoglobin pada pasien anak dengan infeksi virus dengue sebagian besar dalam kadar normal dan tidak semua menunjukkan uji tourniquet positif.Kata kunci: dengue, kadar hemoglobin, uji tourniquet

scholarly journals NS-1 antigen positive Dengue Infection and molecular characterization of Dengue Viruses in a private Medical College Hospitalin Dhaka, Bangladesh

2018 ◽  
Vol 17 (4) ◽  
pp. 669-673
Author(s):  
Mahmuda Siddiqua ◽  
Ahmed Nawsher Alam ◽  
AKM Muraduzzaman ◽  
Tahmina Shirin
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Medical Science ◽  
Cost Effective ◽  
Rt Pcr ◽  
Dengue Virus Infection ◽  
Medical College ◽  
Virus Serotype ◽  
Ns1 Antigen

Introduction: Detection of dengue virus infection as soon as possible is critical for management of dengue virus infected patients. Immuno-chromatographic (ICT) tests are easy, cost effective method for dengue virus antigen detection.The sensitivity and specificity of ICT should compare with a gold standard test like RT-PCR. Aim of this study was to compare two test methods (ICT and RT-PCR), observe dengue serotype and seasonal impact on dengue infection.Methodology & result: The patients of Ibn Sina Medical College Hospital from October 2015 to October 2017 were tested for dengue NS1 antigen by ICT method. Out of 3201 sample tested 32.39% were found positive and 89 of which were re-tested for RT-PCR for comparison. Eighty eight of 89 NS1 positive cases showed positive by RT-PCR method giving an accuracy of 98.87%. Among the RT-PCR positive cases 45 were further analyzed for serotype. DEN-1, DEN-2 or both DEN- 1 and DEN-2 were found in 21, 23 and 1cases respectively. No cases of DEN-3 or DEN-4 were detected.Conclusion: This study showed that easily available and cost effective dengue NS1 antigen detection method (ICT) is as effective as molecular test (RT-PCR). DEN-1 and DEN-2 serotype were prevalent during last few years in Bangladesh. Continuous monitoring of dengue virus serotype is important for prevention and control of sudden epidemic by other serotype. Alert to be more during post monsoon when the peak of dengue virus infection was observed.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.669-673

A SPATIAL CLUSTERING APPROACH TO IDENTIFY RISK AREAS OF DENGUE INFECTION AFTER INSECTICIDE SPRAYING

2016 ◽  
Vol 78 (5-3) ◽  
Author(s):  
Napadol Sudsom ◽  
Suwich Thammapalo ◽  
Theerakamol Pengsakul ◽  
Kuaanan Techato
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Spatial Clustering ◽  
Dengue Infection ◽  
Spatial Association ◽  
Dengue Vector ◽  
Dengue Virus Infection ◽  
Spatial Analyst ◽  
Risk Areas ◽  
Clustering Approach

This study aims to demonstrate a spatial clustering approach for identifying risk households of dengue virus infection during the period of insecticide spraying-ultra low volume (ULV). All households located within 100 m radius of spraying area were recorded with geographic coordinates and divide into three groups of spraying (unsprayed, only outdoor and indoor plus outdoor sprayed house). A total of 45 households with geographic coordinates, were randomly selected to monitor ovitrap index, the percentage of positive ovitraps and the number of eggs per trap, in pre- and post-ULV spraying. Application of spatial analyst tools and spatial statistics tools in ArcGIS 10.1 were used to determine mosquito density and identify risk households using ovitrap index. The prediction maps of Aedes aegypti vector abundance were illustrated by kriging technique. Base on the results, the cluster of Ae. aegypti populations were detected on four day after the spraying. This finding shows the significant spatial pattern of dengue vector populations which may cause high risk areas of dengue virus infection after insecticide treatment. This methodological framework could be used for improving the strategy of dengue vector and outbreak control. The spatial association between dengue vector and the coverage of space spraying requires further study.

Neonate with haemophagocytic lymphohistiocytosis secondary to dengue infection: a case report

2016 ◽  
Vol 47 (3) ◽  
pp. 253-255 ◽  
Author(s):  
MV Krithika ◽  
Prakash Amboiram ◽  
Sneha M Latha ◽  
Binu Ninan ◽  
Febe Renjitha Suman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Dengue Virus Infection ◽  
The Third ◽  
First Case

We report the first case of haemophagocytic lymphohistiocytosis (HLH) in a neonate secondary to primary Dengue virus infection. This neonate presented in the third week of life with fever, shock and hepatosplenomegaly and was diagnosed to have Dengue infection by serology and HLH was confirmed on bone marrow.

scholarly journals Detection of Proteinuria by Colorimetric Method and Correlation with Disease Severity in Patients Dengue

2021 ◽  
Vol 27 (3) ◽  
pp. 244
Author(s):  
Acivrida Mega Charisma ◽  
Elis Anita Farida ◽  
Farida Anwari
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Infection ◽  
Urine Samples ◽  
P Value ◽  
Urine Protein ◽  
Dengue Virus Infection ◽  
Chi Square ◽  
Chi Square Test

Severe dengue virus infection often causes proteinuria through several mechanisms, such as leakage of plasma proteins caused by higher protein filtering in the kidneys. The condition of proteinuria in patients with dengue shock syndrome will affect the management, prognosis, and mortality of patients with dengue virus infection. The objectives of this study were to determine the presence of protein in urine samples in patients in which IgG/IgM dengue was detected, to determine the presence of protein in urine samples in patients without dengue infection, and to determine the relationship between proteinuria in dengue patients and the degree of disease severity. The study was conducted in March-June 2020 at the Clinical Laboratory and Inpatient Clinic of Vita Medika Kepung, Kediri Regency. The method used was the consecutive sampling technique. The minimum sample size was 100 respondents with criteria for suspected dengue infection, onset fever > 4 days, age > 2 years, and no indication of other infectious diseases (blood and urine), divided into two groups, group with positive dengue infection and non-dengue group. The results showed that proteinuria was detected in 26% of respondents, secondary dengue infection and positive serological test of IgG, IgM only IgG were detected in 24 (92.3%) respondents and positive IgG and IgM were found in 2 (7.7%) respondents, this was shown by the p-value = 0.000 in the Chi-Square test with a Prevalence Ratio (PR) value of 11,987. In addition, Chi-Square test results indicated that a higher urine protein/albumin led to more severe disease, with p-value = 0.012 and 0.025 (p <0.05) and PR values of 3.333 and 2.800. The results of this study concluded that there was a close relationship between high levels of protein/albumin in the urine with the degree of disease severity in patients with dengue infection. In addition, an increase in urine protein/albumin levels is always followed by a decrease in serum protein/albumin levels.

scholarly journals Prevalence of Dengue Virus Infection Among Febrile Outpatients Attending University of Maiduguri Teaching Hospital in Borno State, Nigeria

2017 ◽  
Vol 16 (06) ◽  
pp. 155-159
Author(s):  
T.M. Hamisu ◽  
A.D. El- Yuguda ◽  
M.B Abubakar ◽  
Y.M. Shettima ◽  
M.M. Maina ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Teaching Hospital ◽  
Dengue Virus Infection

scholarly journals The Role Activity of Complement, TNFα & IL12 in Pathogenesis Dengue Virus

2010 ◽  
Vol 1 (1) ◽  
pp. 44
Author(s):  
Soegeng Soegijanto ◽  
Dian Dwi Sary ◽  
Budi Setiawan ◽  
Atsushi Yamanaka
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Hemorrhagic Fever ◽  
Study Groups ◽  
Dengue Virus Infection ◽  
Cross Sectional ◽  
Complement Activity ◽  
Grade Iii

Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial. The aim of this study is to analyze the role complement activity, TNFα & IL12 in Dengue Virus infection especially in pathogenesis of Dengue Virus infection. Cross sectional study had been done since February 2009 in Dr. Soetomo Hospital Surabaya. Blood Sera of Dengue Virus infection were collected from Dengue Fever, and Dengue Hemorrhagic Fever patient who had been care in Paediatric. Dengue patients and time schedule for taking blood sample for examination CH50, TNFα & IL12 as follow: on the first day on admission, the second day, the third day. Study groups of patients as follow: Dengue Fever, 36; Dengue Hemorrhagic Fever grade I, 37; Dengue Hemorrhagic Fever grade II, 10; Dengue Hemorrhagic Fever grade III, 18; Dengue Hemorrhagic Fever grade IV, 6. In this study found that the higher activity complement which lower level CH50 was more identified on Dengue Shock Syndrome and Dengue Hemorrhagic Fever grade III than Dengue Fever cases. A concept of our study was focusing on manifestation of vascular leakage, measurement of complement activity CH50, TNFα & IL12 and clinical manifestation Dengue Hemorrhagic Fever. The examination of TNFα & IL12 in our study supported the role the activity complement. The conclusion are measurement CH50, TNFα & IL12 can be used as a predictive factor of the degree of Dengue Virus infection

scholarly journals 1768. Dengue Virus Infection in Solid-Organ Transplant Recipients: Case Series and Literature Review

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S651-S652
Author(s):  
Fernando Rosso ◽  
Ana M Sanz ◽  
Luis Gabriel Parra-Lara ◽  
Pablo A Moncada ◽  
Juan D Vélez ◽  
...  
Keyword(s):  
Virus Infection ◽  
Literature Review ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Organ Transplant ◽  
Case Series ◽  
Solid Organ Transplant ◽  
Severe Dengue ◽  
Solid Organ ◽  
Dengue Virus Infection

Abstract Background Dengue fever is the most prevalent arbovirus among humans, its incidence has increased since the re-emergence, and Colombia is a hyperendemic country for this infection. The number of solid-organ transplant (SOT) recipients, at risk of acquiring dengue virus infection, is constantly increasing, and there are few data regarding the clinical course and outcomes of dengue infection among this population. The aim of this study was to describe dengue virus infection in SOT recipients in Cali, Colombia. Methods We present a case series of SOT recipients with dengue virus infection, diagnosed by World Health Organization criteria and a positive NS1 and/or IgM dengue antibodies, which were attended at the FVL from 2001 to 2018. Furthermore, we performed a literature review regarding dengue infection in SOT recipients. Results A total of 20 patients were included: 17 kidney and 3 liver recipients. The median age was 50.5 years (IQR = 31–63.5), 65% were female. The median time from transplant to dengue was 27.6 months (IQR = 3.82–59.12), and 3 patients had the infection in the first month after the transplant. The most common symptoms were fever (95%), myalgia, headache, and abdominal pain. Warning signs were present in 75% of patients, thrombocytopenia and hemorrhagic manifestations were present in 30% and 15%, respectively. 35% of patients were classified as severe dengue, and 45% were managed at the intensive care unit. Regarding laboratory findings, six patients had transaminases elevation more than three times the upper limit and 7 had serum creatinine elevation, which returned to normal levels. All patients were discharged and none of them had alterations in the graft function. To date, there are approximately 180 reported cases of dengue in SOT recipients (Table 2). Conclusion Dengue represents a threat among SOT recipients. Unlike other reports, all patients in this series had a full recovery after the infection, suggesting that timely and effective management of patients and the access to high complexity services could prevent fatal cases. Disclosures All authors: No reported disclosures.

scholarly journals Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

Blood ◽  
2013 ◽  
Vol 122 (20) ◽  
pp. 3405-3414 ◽  
Author(s):  
Eugenio D. Hottz ◽  
Juliana F. Lopes ◽  
Carla Freitas ◽  
Rogério Valls-de-Souza ◽  
Marcus F. Oliveira ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Vascular Permeability ◽  
Nlrp3 Inflammasome ◽  
Dengue Infection ◽  
Inflammasome Activation ◽  
Dengue Virus Infection ◽  
Nlrp3 Inflammasome Activation ◽  
Key Points ◽  
Endothelium Permeability

Key Points Dengue infection triggers functional inflammasome assembly in platelets. Platelets may contribute to increased vascular permeability in dengue virus infection by synthesis and release of IL-1β.

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