In this paper, a methodology for the optimization of a single off-shore gas compression station is developed. The station is composed of three gas turbines, each one driving a centrifugal compressor. The study concerns the feasibility of the most suitable arrangement to face the depletion of wells and the consequent reduction of the head top pressure. Once the arrangement is chosen, an optimization procedure is developed and carried out. The procedure, which is aimed at obtaining either high production rates or good station efficiency, is based on knowledge of the centrifugal compressor characteristics and on the availability of gas turbine thermodynamic cycle program, the latter allowing the definition of the machine actual operating state.