Tumor Necrosis Factor Alpha (TNF-α) –308G/A Polymorphism and the Risk of Multiple Myeloma: A Meta-analysis of Pooled Data from 12 Case-control Studies

Background: Mounting evidence has suggested tumor necrosis factor-alpha (TNF-α) can promote the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results are quite different. Objectives: To comprehensively address this issue, we performed the meta-analysis to evaluate the association of TNF-α-308 G/A and -238 G/A polymorphism with DR. Method: Data were retrieved in a systematic manner and analyzed using STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Allelic and genotypic comparisons between cases and controls were evaluated. Results: For the TNF-α-308 G/A polymorphism, overall analysis suggested a marginal association with DR [the OR(95%CI) of (GA versus GG), (GA + AA) versus GG, and (A versus G) are 1.21(1.04, 1.41), 1.20(1.03, 1.39), and 1.14(1.01, 1.30), respectively]. And the subgroup analysis indicated an enhanced association among the European population. For the TNF-α-238 G/A polymorphism, there was mild correlation in the entire group [the OR(95%CI) of (GA versus GG) is 1.55(1.14,2.11) ], which was strengthened among the Asian population. Conclusion: The meta-analysis suggested that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.

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Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case–control study and meta-analysis

Journal of Cardiovascular Disease Research ◽

10.4103/0975-3583.95359 ◽

2012 ◽

Vol 3 (2) ◽

pp. 84-90 ◽

Cited By ~ 25

Author(s):

Hongxia Chu ◽

Jun Yang ◽

Shaohua Mi ◽

Soumitra Sudip Bhuyan ◽

Jun Li ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Tumor Necrosis ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor ◽

Control Study

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-308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and metabolic syndrome susceptibility: a meta-analysis

Scientific Reports ◽

10.1038/s41598-021-83321-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Dong Wang ◽

Liqun He ◽

Xiaotian Zhang

Keyword(s):

Metabolic Syndrome ◽

Tumor Necrosis ◽

Meta Analysis ◽

Dominant Model ◽

Necrosis Factor Alpha ◽

Increased Risk ◽

Tnf Α ◽

Factor Alpha ◽

Allele Model ◽

Necrosis Factor

AbstractMany studies tried to assess the relationship between -308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and risk of metabolic syndrome (MS), but their results were contradictory. This meta-analysis aimed to precisely evaluate this association. A systematic literature search was performed in Pubmed database and WanFang Med Online, STATA software 14.0 was used for the meta-analysis. Eleven independent studies containing 3277 cases and 3312 controls were included in our meta-analysis. In overall analysis, significant association was found between -308G/A polymorphism of TNF-α and MS in both allele model (OR 1.47, 95% CI 1.09–1.98, P 0.013) and dominant model (OR 1.77, 95% CI 1.21–2.58, P 0.003). In the subgroup analysis, the A allele was associated with increased risk of MS in Asia group (allele model: OR 1.82 95% CI 1.31–2.53, P < 0.001; dominant model: OR 2.30, 95% CI 1.64–3.21 P < 0.001; homozygous model: OR 2.29, 95% CI 1.31–4.01, P 0.004), and decreased risk of MS in Europe group (dominant model: OR 0.83, 95% CI 0.70–0.99, P < 0.001; recessive model: OR 0.51, 95% CI 0.28–0.92, P 0.025; homozygous model: OR 0.49 95% CI 0.27–0.89, P 0.02). The A allele also appeared to linked to increased risk of MS in CDS group and IDF groups. No significant association was observed in NCEPATPIII group. Our results suggested that -308G/A of TNF-α gene was a risk factor for MS, but it may played different roles in different ethnics, further studies with larger sample size and more other ethnics should be performed to confirm our conclusions.

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Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Life ◽

10.3390/life10060087 ◽

2020 ◽

Vol 10 (6) ◽

pp. 87 ◽

Cited By ~ 1

Author(s):

Mohammad Moslem Imani ◽

Masoud Sadeghi ◽

Habibolah Khazaie ◽

Mehrdad Emami ◽

Dena Sadeghi Bahmani ◽

...

Keyword(s):

Tumor Necrosis ◽

Meta Analysis ◽

Sleep Apnea Syndrome ◽

Necrosis Factor Alpha ◽

Obstructive Sleep ◽

Tnf Α ◽

Factor Alpha ◽

Meta Regression ◽

Apnea Syndrome ◽

Necrosis Factor

Background: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to 1 February 2020. Results: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; p < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; p = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001). Conclusions: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma.

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