scholarly journals Anti-retro viral therapy adverse drug reaction and associated factors among human immuno deficiency virus infected adult patients at Nigist Eleni Mohammed Memorial hospital, South Ethiopia

2020 ◽  
Vol 20 (2) ◽  
pp. 560-567
Author(s):  
Temesgen Tamirat ◽  
Kifle Woldemichael ◽  
Tsegaye Tewelde ◽  
Tariku Laelago
Keyword(s):  
Adverse Drug Reactions ◽  
Health Care Providers ◽  
Associated Factors ◽  
Adult Patients ◽  
Hiv Care ◽  
Stage Iii ◽  
Memorial Hospital ◽  
Care Providers ◽  
Drug Reactions ◽  
Infected Adult

Background: Recent increases in access to HAART have made the management of drug toxicities an increasingly crucial component of HIV care in developing countries. The aim of this study was to determine prevalence of antiretroviral ther- apy adverse drug reactions and associated factors among HIV-infected adult patients at Nigist Eleni Mohammed memorial hospital. Methods: A cross sectional study was conducted by retrospective review of patients’ medical records. From a total 721 adult patient records, 231 patients record were selected by simple random sampling technique. The study was conducted April15-25, 2015.The association between dependent and independent variables was measured by using OR at 95% CI. P-value <0.05 was considered as statistically significant. Result: About 53(22.9%) patients developed ADRs (adverse drug reactions). Female (AOR=2.72, CI=1.177-6.30), patients with WHO stage III and IV (AOR= 13.06, CI=4.17- 40.90) were found more likely to develop ADRs. Commonly identified ADRs were fatigue (18.1%), diarrhea (7.7%), nausea (6.5%), headache (3.6%) and anemia (2%). Conclusion: Nearly one in five patients develop ADRs. Sex of respondents, WHO stage and functional status were asso- ciated with ADRs. The health care providers should give due attention to ambulatory, bedridden, and WHO stage III and IV patients. Keywords: ART; HIV; AIDS; Ethiopia.

scholarly journals A study on determinants of underreporting of adverse drug reactions among resident doctors

2018 ◽  
Vol 6 (2) ◽  
pp. 623 ◽  
Author(s):  
Rohini Gupta ◽  
Apoorva Malhotra ◽  
Pavan Malhotra
Keyword(s):  
Adverse Drug Reactions ◽  
Health Care Providers ◽  
Critical Role ◽  
Care Providers ◽  
Drug Reactions ◽  
Cross Sectional ◽  
National Programme ◽  
Adr Reporting ◽  
Self Administered Questionnaire ◽  
Suspected Adverse Drug Reactions

Background: Adverse Drug Reactions (ADRs) are global problem with significant morbidity and mortality. Health care providers/professionals (HCPs) play a critical role in ADR surveillance. However, only 6% of all ADRs are reported and under-reporting acts as great impedance in exchange of drug information. Thus, spontaneous reporting of suspected adverse drug reactions requires greater commitment from healthcare professionals. The aim was to determine the reasons of underreporting of ADRs among resident doctors.Methods: This was a cross-sectional observational study with self-administered questionnaire assessing the reasons for underreporting of ADRs among resident doctors.Results: Very low level of awareness about ADR reporting was found among doctors. Eighty eight percent of doctors did not know the authority and the procedure for ADR reporting. About 32.8% were not sure with the reaction and the drug, while 46.3% doctors felt that there is no need of reporting the recognized reactions again. Other factors responsible for under reporting were lack of time in 73% and cumbersome procedure in 45% of the participants.Conclusions: A poor level of awareness of pharmacovigilance was seen among doctors. Measure to improve awareness, accessible systems for reporting and effective National Programme are required to improve reporting

scholarly journals Unavailability of Outpatient Medications: Examples and Opportunities for Management

2017 ◽  
Vol 33 (3) ◽  
pp. 83-86 ◽  
Author(s):  
Milena M. McLaughlin ◽  
Jenny Lin ◽  
Rosie Nguyen ◽  
Pratixa Patel ◽  
Erin R. Fox
Keyword(s):  
Health Care ◽  
Adverse Drug Reactions ◽  
Health Care Providers ◽  
Community Pharmacist ◽  
Care Providers ◽  
Drug Reactions ◽  
Drug Shortages ◽  
Medication Therapy ◽  
Outpatient Drug

Drug shortages create significant challenges for patients and health care providers. Pharmacists play important roles in managing medication therapy during drug shortages. The management of drug shortages by the community pharmacist is an expanding role. Adverse drug reactions and delayed treatments are highlighted in the literature as some of the consequences of outpatient drug shortages; it is likely these harms are underreported. This commentary reviews examples and opportunities for the management of outpatient drug shortages.

scholarly journals Orofacial Manifestation of Adverse Drug Reactions: A Review Study

2018 ◽  
Vol 91 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Sedigheh Bakhtiari ◽  
Marziye Sehatpour ◽  
Hamed Mortazavi ◽  
Mahin Bakhshi
Keyword(s):  
Salivary Glands ◽  
Adverse Drug Reactions ◽  
Health Care Providers ◽  
Clinical Manifestations ◽  
Care Providers ◽  
Drug Reactions ◽  
Hard Tissue ◽  
Mesh Terms ◽  
Dental Practitioners ◽  
Mucosal Involvement

Background. Adverse reaction to medication is common and may have a variety of clinical manifestations in the oral cavity. The present review paper aimed to describe adverse drug reactions (ADRs) which might be encountered by dental practitioners in every discipline.Methods. In this narrative review article, the specialized databases such as PubMed, PubMed Central, MEDLINE, EBSCO, Science Direct, Scopus, and reference books from the years 2000-2016 were used to find relevant documents by using MeSH terms: Adverse Drug Reaction, Drug induced, Medication Related, Mouth, Oral Manifestation, Tooth, Hard Tissue, Soft Tissue.Results. The data were categorized in 4 groups as follows: saliva and salivary glands involvement, soft tissue (mucosal) involvement, hard tissue involvement, and non specific conditions (taste disorders, halitosis, neuropathies, movement disturbances, and infection). Most articles were about the adverse effect of drugs on the function of salivary glands, which often cause a decrease in saliva secretion. Other reactions were less common; meanwhile, the side effect of bisphosphonate was increasing in the alveolar bone, because of its unlimited prescription.Conclusion. Oral health care providers should be familiar with such events, as they will be confronted with them in their practice.

scholarly journals Antiretroviral-induced adverse drug reactions in HIV-infected patients in Mali: a resource-limited setting experience

2019 ◽  
Vol 8 (5) ◽  
pp. 831 ◽  
Author(s):  
Aboubacar Alassane Oumar ◽  
Mamadou Dakouo ◽  
Anicet Tchibozo ◽  
Mamoudou Maiga ◽  
Guida Landouré ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peripheral Neuropathy ◽  
Adverse Drug Reactions ◽  
Female Gender ◽  
Adult Patients ◽  
Sub Saharan Africa ◽  
Hiv Care ◽  
Drug Reactions ◽  
Active Monitoring ◽  
Skin Reactions

Background: There are few reports in the literature from sub-Saharan Africa (SSA) regarding antiretroviral-induced adverse drug reactions (ADRs). Antiretroviral therapy (ART) is now widely available in SSA, and ADRs during HIV infection are also frequent. In this study, we reported the frequency and risk factors of ART-induced ADRs in a Malian population.Methods: This prospective cohort study was performed in the HIV Care and Counseling Centre (CESAC) of Mali from 2011 to 2012. Adult patients infected with HIV and who had recently started ART were included and followed-up clinically Were included in this study, adult patients living with HIV and had recently started ART who were followed up for at least 6 months to determine the incidence of ADRs using Naranjo’s classification scale.Results: During this study, 357 (42.3%) patients presented ADRs (40.1% of our patients (n=338) experienced at least one ADR, and 2.2% (n=19) experienced at least two ADRs). The prevalence of ADRs by organ system was: 45.9% neurological (n=164); 29.4% metabolic (blood chemistry) (n=105); 15.4% hematological (n=55). High probable rate of ADR was observed as indicated by the Naranjo score in 83.7% of the cases. Zidovudine (AZT) and stavudine (d4T) use was identified as a risk factor for either anaemia or peripheral neuropathy whereas nevirapine (NVP) and female gender were risk factors for skin reactions. Patients with advance disease had the highest rate of ADRs compared to the others.Conclusions: Based on the Naranjo probability scale, our data show that ADRs such as peripheral neuropathy and anemia are very frequent. These ADR was linked to AZT and D4T. Our findings highlight the need for active monitoring, continuous pharmacovigilance of ART and change of some ART drug in this population.

Adverse Drug Reactions and the Food and Drug Administration

1989 ◽  
Vol 2 (4) ◽  
pp. 209-213 ◽  
Author(s):  
Kay C. Pearson ◽  
Dianne L. Kennedy
Keyword(s):  
Adverse Drug Reactions ◽  
Drug Administration ◽  
Health Care Providers ◽  
Food And Drug Administration ◽  
Improve Patient Care ◽  
The United States ◽  
Care Providers ◽  
Drug Reactions ◽  
Us Government ◽  
Government Work

The monitoring of adverse drug reactions (ADRs) after a drug is marketed is an important mission for the US Food and Drug Administration (FDA). Currently, the FDA receives and computerizes nearly 60,000 ADR reports each year. The FDA has an active postmarketing surveillance system in place to effectively triage, tabulate, analyze, and evaluate these reports. Of highest priority to FDA are the discovery of serious reactions that were not observed before a drug was marketed and the detection of increased occurrence of serious reactions that are known to occur with the drug. All reactions for new moieties marketed in the United States during their first 3 years are of interest. Pharmacists are in a unique position to be aware of adverse reactions because of their knowledge of drugs, their close working relationships with other health care providers, and their direct interactions with patients. By participating in FDA's ADR reporting system, pharmacists can actively contribute to drug safety and help improve patient care. This is a US government work. There are no restrictions on its use.

scholarly journals A Study on Adverse Drug Reactions in a Tertiary Care Hospital of South India

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Sherin Shaji ◽  
Mahadevamma Lingaiah ◽  
Swathi Ramesh ◽  
Amal Balakrishnakurup Kovattu
Keyword(s):  
Adverse Drug Reactions ◽  
Health Care Providers ◽  
Tertiary Care ◽  
Public Health Issue ◽  
Pharmacovigilance Centre ◽  
Care Hospital ◽  
Age Group ◽  
Care Providers ◽  
Drug Reactions ◽  
Study Results

Medication-related adverse events or adverse drug reactions (ADRs) are harmful events caused by medication. ADRs could have profound effects on the patients’ quality of life, as well as creating an increased burden on the healthcare system. ADRs are one of the rising causes of morbidity and mortality internationally, and will continue to be a significant public health issue with the increased complexity in medication, to treat various diseases in an aging society. This was a prospective and observational study conducted in medicine department of sagar hospital, Bengaluru. Patients were enrolled based on the criteria with a suitable statistical tool. Among 64 patients, 33 (51.6%) female and 33 (48.44%) were males found. ADRs were more in the age group of 41 – 60, 32 (50%), less in the age group is 0 – 20, 04 (6.25%). Significantly higher numbers of ADRs caused by the antibiotics 25 (39%) followed by antihyperlipidicmic and anti-arrythmic 01 (1.56%), Most of the ADRs were moderate 40 (62.5%) and sever 01 (1.56%) in nature. Most commonly affected organ is dermatological system 32 (50%). Majority of the ADRs were associated with antibiotics. Commonly skin related ADRs was found in this study. The results provided an insight to the Health care Providers on the importance of monitoring and reporting of ADRs. Our study results emphasize a need for establishing a pharmacovigilance centre to ensure the safe use of drugs.

scholarly journals Client satisfaction with existing postnatal care and associated factors: A study among mothers in Awi Zone, Amhara region, Ethiopia

2020 ◽  
Vol 16 ◽  
pp. 174550652097601
Author(s):  
Daniel Adane ◽  
Biresaw Wassihun
Keyword(s):  
Antenatal Care ◽  
Health Care Providers ◽  
Postnatal Care ◽  
Associated Factors ◽  
Client Satisfaction ◽  
Post Partum ◽  
Care Providers ◽  
Amhara Region ◽  
Awi Zone

Background: The majority of maternal and neonatal adverse events take place during the postnatal period. However, it is the most neglected period for the provision of quality care. Objective: The aim of this study among mothers in the Awi Zone, Amhara region, Ethiopia, was to assess client satisfaction with existing postnatal care and associated factors. Methods: An institution-based cross-sectional study was conducted in Awi Zone hospitals from 1 to 30 April 2018. A total of 422 post-partum mothers were selected by systematic sampling. The data were collected using a pre-tested structured questionnaire via a face-to-face interview. Data entry and analysis were completed using EpiData version 3.1 and SPSS version 22, respectively. The data were summarized with frequency and cross-tabulation. Both binary and multiple logistic regressions were used to identify predictor variables using odds ratios and 95% confidence intervals. Result: The prevalence of postnatal care satisfaction was 63%. Being from urban area (AOR = 2.1, 95% CI = (1.11–3.99)), having a history of antenatal care follow up (AOR = 1.62, 95% CI = (1.23–1.64)), spontaneous vaginal birth (AOR = 3.14, 95% CI = (1.77–3.28)), and those who did not face any complications during birth (AOR = 2.90, 95% CI = (1.47–1.69)) were some of the factors associated with client satisfaction. Conclusion: According to the results of this study, the majority of mothers were satisfied with post-partum care services. The study findings indicate that maternal satisfaction on post-partum care is mainly affected by residency, antenatal care follow up, mode of delivery, and complications during birth. Therefore, health care providers and other concerned bodies should give special attention to those mothers who are from rural areas, who face complications during birth or who have instrumental-assisted or cesarean section birth. Also, every pregnant mother should be supported to have at least four regular antenatal care visits.

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